(data stored in ACNUC6163 zone)

HOVERGEN: Q6ZU25_HUMAN

ID   Q6ZU25_HUMAN            Unreviewed;       968 AA.
AC   Q6ZU25;
DT   05-JUL-2004, integrated into UniProtKB/TrEMBL.
DT   05-JUL-2004, sequence version 1.
DT   03-NOV-2009, entry version 43.
DE   SubName: Full=cDNA FLJ44043 fis, clone TESTI4029836, highly similar to Potential phospholipid-transporting ATPase IB (EC 3.6.3.13);
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Testis;
RA   Ota T., Nakagawa S., Senoh A., Mizuguchi H., Inagaki H., Sugiyama T.,
RA   Irie R., Otsuki T., Sato H., Wakamatsu A., Ishii S., Yamamoto J.,
RA   Isono Y., Kawai-Hio Y., Saito K., Nishikawa T., Kimura K.,
RA   Yamashita H., Matsuo K., Nakamura Y., Sekine M., Kikuchi H., Kanda K.,
RA   Wagatsuma M., Murakawa K., Kanehori K., Takahashi-Fujii A., Oshima A.,
RA   Sugiyama A., Kawakami B., Suzuki Y., Sugano S., Nagahari K.,
RA   Masuho Y., Nagai K., Isogai T.;
RT   "NEDO human cDNA sequencing project.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY: ATP + H(2)O + phospholipid(In) = ADP +
CC       phosphate + phospholipid(Out).
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CC   -!- GENE_FAMILY: HBG050601 [ FAMILY / ALN / TREE ]
DR   EMBL; AK126031; BAC86402.1; -; mRNA.
DR   IPI; IPI00465166; -.
DR   RefSeq; NP_057613.4; -.
DR   UniGene; Hs.444957; -.
DR   STRING; Q6ZU25; -.
DR   Ensembl; ENST00000255283; ENSP00000255283; ENSG00000132932; Homo sapiens.
DR   Ensembl; ENST00000281620; ENSP00000281620; ENSG00000132932; Homo sapiens.
DR   Ensembl; ENST00000381648; ENSP00000371062; ENSG00000132932; Homo sapiens.
DR   Ensembl; ENST00000381655; ENSP00000371070; ENSG00000132932; Homo sapiens.
DR   GeneID; 51761; -.
DR   HGNC; HGNC:13533; ATP8A2.
DR   HOVERGEN; Q6ZU25; -.
DR   ArrayExpress; Q6ZU25; -.
DR   Bgee; Q6ZU25; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015662; F:ATPase activity, coupled to transmembrane m...; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004012; F:phospholipid-translocating ATPase activity; IEA:InterPro.
DR   GO; GO:0006754; P:ATP biosynthetic process; IEA:InterPro.
DR   GO; GO:0015914; P:phospholipid transport; IEA:InterPro.
DR   InterPro; IPR001757; ATPase_P-typ_ion-transptr.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR006539; ATPase_P-typ_Plipid-transl.
DR   PANTHER; PTHR11939; ATPase_P; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   TIGRFAMs; TIGR01652; ATPase-Plipid; 1.
DR   TIGRFAMs; TIGR01494; ATPase_P-type; 3.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q6ZU25.
DR   SWISS-2DPAGE; Q6ZU25.
KW   ATP-binding; Hydrolase; Magnesium; Membrane; Nucleotide-binding;
KW   Transmembrane.
FT   DOMAIN       24     75       PRODOM:2005.1:PD004982  138
FT   DOMAIN       76    158       PRODOM:2005.1:PD006317  109
FT   DOMAIN      160    190       PRODOM:2005.1:PD876157  42
FT   DOMAIN      193    231       PRODOM:2005.1:PD864285  143
FT   DOMAIN      232    274       PRODOM:2005.1:PDA1F608  4
FT   DOMAIN      275    336       PRODOM:2005.1:PD003346  121
FT   DOMAIN      356    397       PRODOM:2005.1:PD461286  88
FT   DOMAIN      400    448       PRODOM:2005.1:PD250570  129
FT   DOMAIN      450    481       PRODOM:2005.1:PD336512  128
FT   DOMAIN      482    517       PRODOM:2005.1:PD030421  130
FT   DOMAIN      523    575       PRODOM:2005.1:PD004657  92
FT   DOMAIN      595    632       PRODOM:2005.1:PD005736  137
FT   DOMAIN      634    676       PRODOM:2005.1:PD435496  137
FT   DOMAIN      677    732       PRODOM:2005.1:PD304524  143
FT   DOMAIN      781    830       PRODOM:2005.1:PDA1E1E9  67
FT   DOMAIN      832    902       PRODOM:2005.1:PD038238  8
FT   DOMAIN      909    964       PRODOM:2005.1:PD689570  11
SQ   SEQUENCE   968 AA;  109095 MW;  10808BD52A61C1F6 CRC64;
     MRCPGPRLLE TSWRHPPAPF TSTNRHLYDF TGNLNLDGKS LVALGPDQIL LRGTQLRNTQ
     WVFGIVVYTG HDTKLMQNST KAPLKRSNVE KVTNVQILVL FGILLVMALV SSAGALYWNR
     SHGEKNWYIK KMDTTSDNFG YNLLTFIILY NNLIPISLLV TLEVVKYTQA LFINWDTDMY
     YIGNDTPAMA RTSNLNEELG QVKYLFSDKT GTLTCNIMNF KKCSIAGVTY GHFPELAREP
     SSDDFCRMPP PCSDSCDFDD PRLLKNIEDR HPTAPCIQEF LTLLAVCHTV VPEKDGDNII
     YQASSPDEAA LVKGAKKLGF VFTARTPFSV IIEAMGQEQT FGILNVLEFS SDRKRMSVIV
     RTPSGRLRLY CKGADNVIFE RLSKDSKYME ETLCHLEYFA TEGFRTLCVA YADLSENEYE
     EWLKVYQEAS TILKDRAQRL EECYEIIEKN LLLLGATAIE DRLQAGVPET IATLLKAEIK
     IWVLTGDKQE TAINIGYSCR LVSQNMALIL LKEDSLDATR AAITQHCTDL GNLLGKENDV
     ALIIDGHTLK YALSFEVRRS FLDLALSCKA VICCRVSPLQ KSEIVDVVKK RVKAITLAIG
     DGANDVGMIQ TAHVGVGISG NEGMQATNNS DYAIAQFSYL EKLLLVHGAW SYNRVTKCIL
     YCFYKNVVLY IIELWFAFVN GFSGQILFER WCIGLYNVIF TALPPFTLGI FERSCTQESM
     LRFPQLYKIT QNGEGFNTKV FWGHCINALV HSLILFWFPM KALEHDTVLT SGHATDYLFV
     GNIVYTYVVV TVCLKAGLET TAWTKFSHLA VWGSMLTWLV FFGIYSTIWP TIPIAPDMRG
     QATMVLSSAH FWLGLFLVPT ACLIEDVAWR AAKHTCKKTL LEEVQELETK SRVLGKAVLR
     DSNGKRLNER DRLIKRLGRK TPPTLFRGSS LQQGVPHGYA FSQEEHGAVS QEEVIRAYDT
     TKKKSRKK
//

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