(data stored in ACNUC13530 zone)

HOVERGEN: Q8UWG6_CHICK

ID   Q8UWG6_CHICK            Unreviewed;       368 AA.
AC   Q8UWG6;
DT   01-MAR-2002, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2002, sequence version 1.
DT   03-NOV-2009, entry version 55.
DE   SubName: Full=Extracellular signal-regulated kinase 2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Pineal gland;
RA   Kasahara T., Higashi C., Okano T., Fukada Y.;
RT   "Cloning of ERK2 expressed in the chicken pineal gland.";
RL   Submitted (APR-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
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CC   -!- GENE_FAMILY: HBG014652 [ FAMILY / ALN / TREE ]
DR   EMBL; AY033635; AAK56503.1; -; mRNA.
DR   IPI; IPI00589069; -.
DR   RefSeq; NP_989481.1; -.
DR   UniGene; Gga.2163; -.
DR   HSSP; P28482; 1PME.
DR   SMR; Q8UWG6; 20-364.
DR   STRING; Q8UWG6; -.
DR   PRIDE; Q8UWG6; -.
DR   Ensembl; ENSGALT00000002280; ENSGALP00000002278; ENSGALG00000001501; Gallus gallus.
DR   Ensembl; ENSGALT00000040001; ENSGALP00000039208; ENSGALG00000001501; Gallus gallus.
DR   GeneID; 373953; -.
DR   KEGG; gga:373953; -.
DR   CTD; 373953; -.
DR   HOGENOM; Q8UWG6; -.
DR   HOVERGEN; Q8UWG6; -.
DR   GO; GO:0005829; C:cytosol; IEA:Compara.
DR   GO; GO:0005634; C:nucleus; IEA:Compara.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016908; F:MAP kinase 2 activity; IEA:Compara.
DR   GO; GO:0001784; F:phosphotyrosine binding; IEA:Compara.
DR   GO; GO:0050853; P:B cell receptor signaling pathway; IEA:Compara.
DR   GO; GO:0019858; P:cytosine metabolic process; IEA:Compara.
DR   GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Compara.
DR   GO; GO:0000165; P:MAPKKK cascade; IEA:Compara.
DR   GO; GO:0045596; P:negative regulation of cell differentiation; IEA:Compara.
DR   GO; GO:0009887; P:organ morphogenesis; IEA:Compara.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:Compara.
DR   GO; GO:0006974; P:response to DNA damage stimulus; IEA:Compara.
DR   GO; GO:0043330; P:response to exogenous dsRNA; IEA:Compara.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEA:Compara.
DR   GO; GO:0050852; P:T cell receptor signaling pathway; IEA:Compara.
DR   InterPro; IPR008349; Erk_1_2_MAPK.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003527; MAP_kinase_CS.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_prot_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_prot_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   PRINTS; PR01770; ERK1ERK2MAPK.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS01351; MAPK; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q8UWG6.
DR   SWISS-2DPAGE; Q8UWG6.
KW   ATP-binding; Kinase; Nucleotide-binding;
KW   Serine/threonine-protein kinase.
FT   DOMAIN       39    238       PRODOM:2005.1:PD000001  8496
FT   DOMAIN      326    362       PRODOM:2005.1:PD054205  105
SQ   SEQUENCE   368 AA;  41942 MW;  A6F3A3D27C6C9A44 CRC64;
     MAAVAGAAAA GGSAGAGGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNVNKVRVA
     IKKISPFEHQ TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL
     YKLLKTQHLS NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR
     VADPDHDHTG FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH
     YLDQLNHILG ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DPKALDLLDK
     MLTFNPHKRI EVEQALAHPY LEQYYDPSDE PVAEAPFKFD MELDDLPKEK LKELIFEETA
     RFQPGYRS
//

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