(data stored in ACNUC1130 zone)

HOVERGEN: Q90975_CHICK

ID   Q90975_CHICK            Unreviewed;      1382 AA.
AC   Q90975; Q90785;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   03-NOV-2009, entry version 66.
DE   SubName: Full=Tyrosine kinase;
GN   Name=c-met;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves;
OC   Neognathae; Galliformes; Phasianidae; Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RX   MEDLINE=96029010; PubMed=7554499; DOI=10.1002/dvg.1020170110;
RA   Thery C., Sharpe M.J., Batley S.J., Stern C.D., Gherardi E.;
RT   "Expression of HGF/SF, HGF1/MSP, and c-met suggests new functions
RT   during early chick development.";
RL   Dev. Genet. 17:90-101(1995).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein
CC       kinase family.
CC   -!- SIMILARITY: Contains 1 Sema domain.
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CC   -!- GENE_FAMILY: HBG006348 [ FAMILY / ALN / TREE ]
DR   EMBL; X84044; CAA58863.1; -; mRNA.
DR   IPI; IPI00818723; -.
DR   RefSeq; NP_990543.1; -.
DR   UniGene; Gga.669; -.
DR   HSSP; P08581; 1R1W.
DR   SMR; Q90975; 1047-1347.
DR   STRING; Q90975; -.
DR   PRIDE; Q90975; -.
DR   Ensembl; ENSGALT00000015300; ENSGALP00000015284; ENSGALG00000009390; Gallus gallus.
DR   Ensembl; ENSGALT00000038938; ENSGALP00000038148; ENSGALG00000009390; Gallus gallus.
DR   GeneID; 396134; -.
DR   KEGG; gga:396134; -.
DR   CTD; 396134; -.
DR   HOGENOM; Q90975; -.
DR   HOVERGEN; Q90975; -.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004872; F:receptor activity; IEA:InterPro.
DR   GO; GO:0007275; P:multicellular organismal development; IEA:InterPro.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IEA:InterPro.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR002909; IPT_TIG_rcpt.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR003659; Plexin-like.
DR   InterPro; IPR016201; Plexin-like_fold.
DR   InterPro; IPR002165; Plexin_repeat.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR001627; Semaphorin/CD100_Ag.
DR   InterPro; IPR020707; Tyr_kinase_hepatocyte_GF_rcpt.
DR   InterPro; IPR008266; Tyr_prot_kinase_AS.
DR   InterPro; IPR001245; Tyr_prot_kinase_cat_dom.
DR   InterPro; IPR016244; Tyr_prot_kinase_HGF/MSP_rcpt.
DR   InterPro; IPR020635; Tyr_prot_kinase_subgr_cat_dom.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR   Gene3D; G3DSA:2.130.10.10; WD40/YVTN_repeat-like; 1.
DR   PANTHER; PTHR23256:SF169; Tyr_kinase_hepatocyte_GF_rcpt; 1.
DR   Pfam; PF07714; Pkinase_Tyr; 1.
DR   Pfam; PF01437; PSI; 1.
DR   Pfam; PF01403; Sema; 1.
DR   Pfam; PF01833; TIG; 3.
DR   PIRSF; PIRSF000617; TyrPK_HGF-R; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00429; IPT; 4.
DR   SMART; SM00423; PSI; 1.
DR   SMART; SM00630; Sema; 1.
DR   SMART; SM00219; TyrKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
DR   PROSITE; PS51004; SEMA; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q90975.
DR   SWISS-2DPAGE; Q90975.
KW   ATP-binding; Kinase; Membrane; Nucleotide-binding; Transmembrane;
KW   Tyrosine-protein kinase.
FT   DOMAIN        1     38       PRODOM:2005.1:PD686693  6
FT   DOMAIN       62    142       PRODOM:2005.1:PD003973  45
FT   DOMAIN      155    226       PRODOM:2005.1:PD962738  14
FT   DOMAIN      245    473       PRODOM:2005.1:PD331587  41
FT   DOMAIN      475    523       PRODOM:2005.1:PD608132  8
FT   DOMAIN      524    612       PRODOM:2005.1:PD001668  42
FT   DOMAIN      613    656       PRODOM:2005.1:PD997012  1
FT   DOMAIN      657    716       PRODOM:2005.1:PD003981  45
FT   DOMAIN      722    901       PRODOM:2005.1:PD591320  41
FT   DOMAIN      902   1083       PRODOM:2005.1:PD464849  8
SQ   SEQUENCE   1382 AA;  154451 MW;  05E1BAEF4239A4F7 CRC64;
     MKPVTAYPSG IILFLFALLQ RSHGQCKEAA KKSEMNLNVK YDLPNFITET PIQNVVLYKH
     HVYIGAVNKI YVLNETLQNI SVYKTGPILE SPGCAPCEDC KDKANLSNSV WKDNVNMALL
     LETYYDDQLI SCGSVSGGVC HRHIIPPDNP ADIESEVHCM YSPQVDGEAD NCPDCVVSTL
     GTKVLVTEKD RFVNFFVGNT MTSAFQPPHV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ
     FRDSYPIKYV HAFEHDHFVY FLTVQRESLD SQTFHTRIIR FCTLDSEMRS YMEMPLECIF
     TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLIDD ILYGVFAQTN QIPQEPTNRS
     AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKDSKYCLNR AFSRNASYCR AQDDEYRLEV
     TTPLQRVDLF MGQFNNILLT SISVFTKGNL TIANLGTSEG RFMQIVVSRS EPTAPHVSFQ
     LDSHAVSPQV VVEQSAAADG YTLVVTGKKI TKVPLNGPGC HHFQSCSQCL LAPAFMRCGW
     CGQQCLRAPE CNGGTWTQET CLPRVYEILP SSAPLEGGTK LTLCGWDFGF SKNNRFELRN
     TVVHIGGQIC ALEAKSSNKN KLECTAPAAK NASFNISSSV SVGHGKTLFN TFSYVNPIIT
     SISPTYGPKS GGTLLTIAGK YLNSGKSRRI FVGEKPCSLK STSESSVECY TPAQRIPQEY
     RVRVGIDGAI RDAKGYFTYR EDPVVLKIHP AKSFLSGGST ITAQGINLNS VCFPRMVITV
     PKLGMNFSVA CSHRSSSEII CCTTPSLKAF NLQPPFVTKV FFIFDGVSSL YFDFDYVNNP
     VFKHFEKPVL ISRSNPNVLE IKGNHIDSEA VKGEVLKVGN KSCENLLLQS ETILCTVPSD
     LLKSNSELNI EWKQEVLSTV IGKVLIRQDQ NFTGLIAGVV STSVLIYIFL VFFLWRRKKK
     QIKDLGSDLV RYDGRVHTPH LDRLVSARSV SPTTEMVSSE SVDYRSTFLE DQFPSMSQNG
     SCRPAQYPHS DLSPILSSGD SDLASPLLQT NVHIDISALN PDLVKEVQHV VIGADSLMVH
     FSEVIGRGHF GCVSHGTLLD NDGRKIHCAV KSLNRITDLE EVAQFLKEGI IMKDFTHPNV
     LSLLGICLPN EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK
     FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK
     FTTKSDVWSF GVLLWELMTR GAPPYPDVNS FDITVYLLQG RRLLQPEYCP DPLYEVMLKC
     WHPKPEMRPA FSELVSKIST IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNTDMDV
     DT
//

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