(data stored in ACNUC13530 zone)

HOVERGEN: Q9CYR7_MOUSE

ID   Q9CYR7_MOUSE            Unreviewed;       303 AA.
AC   Q9CYR7;
DT   01-JUN-2001, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2001, sequence version 1.
DT   03-NOV-2009, entry version 60.
DE   SubName: Full=Putative uncharacterized protein;
GN   Name=Cdk4;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   MEDLINE=99279253; PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA   Carninci P., Hayashizaki Y.;
RT   "High-efficiency full-length cDNA cloning.";
RL   Methods Enzymol. 303:19-44(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   PubMed=16141073; DOI=10.1126/science.1112009;
RG   RIKEN Genome Exploration Research Group and Genome Science Group
RG   (Genome Network Project Core Group) and the FANTOM Consortium;
RT   "Antisense Transcription in the Mammalian Transcriptome.";
RL   Science 309:1564-1566(2005).
RN   [4]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   MEDLINE=22354683; PubMed=12466851; DOI=10.1038/nature01266;
RA   Okazaki Y., Furuno M., Kasukawa T., Adachi J., Bono H., Kondo S.,
RA   Nikaido I., Osato N., Saito R., Suzuki H., Yamanaka I., Kiyosawa H.,
RA   Yagi K., Tomaru Y., Hasegawa Y., Nogami A., Schonbach C., Gojobori T.,
RA   Baldarelli R., Hill D.P., Bult C., Hume D.A., Quackenbush J.,
RA   Schriml L.M., Kanapin A., Matsuda H., Batalov S., Beisel K.W.,
RA   Blake J.A., Bradt D., Brusic V., Chothia C., Corbani L.E., Cousins S.,
RA   Dalla E., Dragani T.A., Fletcher C.F., Forrest A., Frazer K.S.,
RA   Gaasterland T., Gariboldi M., Gissi C., Godzik A., Gough J.,
RA   Grimmond S., Gustincich S., Hirokawa N., Jackson I.J., Jarvis E.D.,
RA   Kanai A., Kawaji H., Kawasawa Y., Kedzierski R.M., King B.L.,
RA   Konagaya A., Kurochkin I.V., Lee Y., Lenhard B., Lyons P.A.,
RA   Maglott D.R., Maltais L., Marchionni L., McKenzie L., Miki H.,
RA   Nagashima T., Numata K., Okido T., Pavan W.J., Pertea G., Pesole G.,
RA   Petrovsky N., Pillai R., Pontius J.U., Qi D., Ramachandran S.,
RA   Ravasi T., Reed J.C., Reed D.J., Reid J., Ring B.Z., Ringwald M.,
RA   Sandelin A., Schneider C., Semple C.A., Setou M., Shimada K.,
RA   Sultana R., Takenaka Y., Taylor M.S., Teasdale R.D., Tomita M.,
RA   Verardo R., Wagner L., Wahlestedt C., Wang Y., Watanabe Y., Wells C.,
RA   Wilming L.G., Wynshaw-Boris A., Yanagisawa M., Yang I., Yang L.,
RA   Yuan Z., Zavolan M., Zhu Y., Zimmer A., Carninci P., Hayatsu N.,
RA   Hirozane-Kishikawa T., Konno H., Nakamura M., Sakazume N., Sato K.,
RA   Shiraki T., Waki K., Kawai J., Aizawa K., Arakawa T., Fukuda S.,
RA   Hara A., Hashizume W., Imotani K., Ishii Y., Itoh M., Kagawa I.,
RA   Miyazaki A., Sakai K., Sasaki D., Shibata K., Shinagawa A.,
RA   Yasunishi A., Yoshino M., Waterston R., Lander E.S., Rogers J.,
RA   Birney E., Hayashizaki Y.;
RT   "Analysis of the mouse transcriptome based on functional annotation of
RT   60,770 full-length cDNAs.";
RL   Nature 420:563-573(2002).
RN   [5]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   MEDLINE=21085660; PubMed=11217851; DOI=10.1038/35055500;
RA   Kawai J., Shinagawa A., Shibata K., Yoshino M., Itoh M., Ishii Y.,
RA   Arakawa T., Hara A., Fukunishi Y., Konno H., Adachi J., Fukuda S.,
RA   Aizawa K., Izawa M., Nishi K., Kiyosawa H., Kondo S., Yamanaka I.,
RA   Saito T., Okazaki Y., Gojobori T., Bono H., Kasukawa T., Saito R.,
RA   Kadota K., Matsuda H.A., Ashburner M., Batalov S., Casavant T.,
RA   Fleischmann W., Gaasterland T., Gissi C., King B., Kochiwa H.,
RA   Kuehl P., Lewis S., Matsuo Y., Nikaido I., Pesole G., Quackenbush J.,
RA   Schriml L.M., Staubli F., Suzuki R., Tomita M., Wagner L., Washio T.,
RA   Sakai K., Okido T., Furuno M., Aono H., Baldarelli R., Barsh G.,
RA   Blake J., Boffelli D., Bojunga N., Carninci P., de Bonaldo M.F.,
RA   Brownstein M.J., Bult C., Fletcher C., Fujita M., Gariboldi M.,
RA   Gustincich S., Hill D., Hofmann M., Hume D.A., Kamiya M., Lee N.H.,
RA   Lyons P., Marchionni L., Mashima J., Mazzarelli J., Mombaerts P.,
RA   Nordone P., Ring B., Ringwald M., Rodriguez I., Sakamoto N.,
RA   Sasaki H., Sato K., Schoenbach C., Seya T., Shibata Y., Storch K.-F.,
RA   Suzuki H., Toyo-oka K., Wang K.H., Weitz C., Whittaker C., Wilming L.,
RA   Wynshaw-Boris A., Yoshida K., Hasegawa Y., Kawaji H., Kohtsuki S.,
RA   Hayashizaki Y.;
RT   "Functional annotation of a full-length mouse cDNA collection.";
RL   Nature 409:685-690(2001).
RN   [6]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   MEDLINE=20499374; PubMed=11042159; DOI=10.1101/gr.145100;
RA   Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA   Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT   "Normalization and subtraction of cap-trapper-selected cDNAs to
RT   prepare full-length cDNA libraries for rapid discovery of new genes.";
RL   Genome Res. 10:1617-1630(2000).
RN   [7]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RX   MEDLINE=20530913; PubMed=11076861; DOI=10.1101/gr.152600;
RA   Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA   Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M.,
RA   Sumi N., Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A.,
RA   Yamamoto R., Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K.,
RA   Fujiwake S., Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M.,
RA   Yoneda Y., Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J.,
RA   Okazaki Y., Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT   "RIKEN integrated sequence analysis (RISA) system--384-format
RT   sequencing pipeline with 384 multicapillary sequencer.";
RL   Genome Res. 10:1757-1771(2000).
RN   [8]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=C57BL/6J; TISSUE=Whole body;
RA   Adachi J., Aizawa K., Akahira S., Akimura T., Arai A., Aono H.,
RA   Arakawa T., Bono H., Carninci P., Fukuda S., Fukunishi Y., Furuno M.,
RA   Hanagaki T., Hara A., Hayatsu N., Hiramoto K., Hiraoka T., Hori F.,
RA   Imotani K., Ishii Y., Itoh M., Izawa M., Kasukawa T., Kato H.,
RA   Kawai J., Kojima Y., Konno H., Kouda M., Koya S., Kurihara C.,
RA   Matsuyama T., Miyazaki A., Nishi K., Nomura K., Numazaki R., Ohno M.,
RA   Okazaki Y., Okido T., Owa C., Saito H., Saito R., Sakai C., Sakai K.,
RA   Sano H., Sasaki D., Shibata K., Shibata Y., Shinagawa A., Shiraki T.,
RA   Sogabe Y., Suzuki H., Tagami M., Tagawa A., Takahashi F., Tanaka T.,
RA   Tejima Y., Toya T., Yamamura T., Yasunishi A., Yoshida K., Yoshino M.,
RA   Muramatsu M., Hayashizaki Y.;
RL   Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily.
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CC   -!- GENE_FAMILY: HBG014652 [ FAMILY / ALN / TREE ]
DR   EMBL; AK013400; BAB28833.1; -; mRNA.
DR   IPI; IPI00128326; -.
DR   UniGene; Mm.6839; -.
DR   HSSP; Q00534; 1BI8.
DR   STRING; Q9CYR7; -.
DR   Ensembl; ENSMUST00000006911; ENSMUSP00000006911; ENSMUSG00000006728; Mus musculus.
DR   Ensembl; ENSMUST00000120226; ENSMUSP00000112549; ENSMUSG00000006728; Mus musculus.
DR   MGI; MGI:88357; Cdk4.
DR   HOVERGEN; Q9CYR7; -.
DR   ArrayExpress; Q9CYR7; -.
DR   Bgee; Q9CYR7; -.
DR   Genevestigator; Q9CYR7; -.
DR   GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme ...; IPI:MGI.
DR   GO; GO:0005667; C:transcription factor complex; IDA:MGI.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004693; F:cyclin-dependent protein kinase activity; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IEA:Compara.
DR   GO; GO:0007623; P:circadian rhythm; IEA:Compara.
DR   GO; GO:0045793; P:positive regulation of cell size; IEA:Compara.
DR   GO; GO:0045727; P:positive regulation of translation; IEA:Compara.
DR   GO; GO:0006468; P:protein amino acid phosphorylation; IDA:MGI.
DR   GO; GO:0051726; P:regulation of cell cycle; IDA:MGI.
DR   GO; GO:0042127; P:regulation of cell proliferation; IMP:MGI.
DR   GO; GO:0007165; P:signal transduction; IDA:MGI.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_prot_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_prot_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_prot_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   ProDom; PD000001; Prot_kinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9CYR7.
DR   SWISS-2DPAGE; Q9CYR7.
KW   ATP-binding; Nucleotide-binding; Serine/threonine-protein kinase.
FT   DOMAIN       12    208       PRODOM:2005.1:PD000001  8496
FT   DOMAIN      227    268       PRODOM:2005.1:PD655854  11
SQ   SEQUENCE   303 AA;  33728 MW;  2ADC7FB2655C48B1 CRC64;
     MAATRYEPVA EIGVGAYGTV YKARDPHSGH FVALKRCEVP NGGAAGGGLP VSTVREVALL
     RRLEAFEHPN VVRLMDVCAN SRTDRDIKVT LMFEHINQDL RTYPDKTPPP GLPVETIKDL
     MRQFLSALDF LHANCIVHRD LKPENILVTS NGTVKLADFG LAKIYSYQMA LTPVVVTLWY
     RAPEVLLQST YATPVDMWSV GCIFAEMFRR TALFCGNSEA DQLGKIFDLI GLPPEDDWPR
     EVSLPRGAFA PRGPRPVQSV VPEMEESGAQ LLLEMLTFNP HKRISASRAL QHSYLHKEES
     DAE
//

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