(data stored in ACNUC4932 zone)

HOVERGEN: Q9ESY2_MOUSE

ID   Q9ESY2_MOUSE            Unreviewed;       520 AA.
AC   Q9ESY2;
DT   01-MAR-2001, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2001, sequence version 1.
DT   03-NOV-2009, entry version 43.
DE   SubName: Full=Inducible 6-phosphofructo-2-kinase;
GN   Name=Pfkfb3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=BALB/c; TISSUE=Spleen;
RX   PubMed=15845370; DOI=10.1016/j.bbrc.2005.02.193;
RA   Chesney J., Telang S., Yalcin A., Clem A., Wallis N., Bucala R.;
RT   "Targeted disruption of inducible 6-phosphofructo-2-kinase results in
RT   embryonic lethality.";
RL   Biochem. Biophys. Res. Commun. 331:139-146(2005).
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CC   -!- GENE_FAMILY: HBG005628 [ FAMILY / ALN / TREE ]
DR   EMBL; AF294617; AAG02118.1; -; mRNA.
DR   IPI; IPI00754131; -.
DR   UniGene; Mm.19669; -.
DR   HSSP; P07953; 1C80.
DR   SMR; Q9ESY2; 35-448.
DR   STRING; Q9ESY2; -.
DR   PhosphoSite; Q9ESY2; -.
DR   Ensembl; ENSMUST00000028114; ENSMUSP00000028114; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000049849; ENSMUSP00000050926; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000091464; ENSMUSP00000089043; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000100411; ENSMUSP00000097979; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000114844; ENSMUSP00000110493; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000114845; ENSMUSP00000110494; ENSMUSG00000026773; Mus musculus.
DR   Ensembl; ENSMUST00000114846; ENSMUSP00000110495; ENSMUSG00000026773; Mus musculus.
DR   UCSC; uc008iie.1; mouse.
DR   MGI; MGI:2181202; Pfkfb3.
DR   HOVERGEN; Q9ESY2; -.
DR   BRENDA; 3.1.3.46; 244.
DR   ArrayExpress; Q9ESY2; -.
DR   Bgee; Q9ESY2; -.
DR   Genevestigator; Q9ESY2; -.
DR   GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR   InterPro; IPR003094; 6Pfruct_kin.
DR   InterPro; IPR013079; 6Phosfructo_kin.
DR   InterPro; IPR016260; Bifunct_6PFK/fruc_bisP_Ptase.
DR   InterPro; IPR001345; PG/BPGM_mutase_AS.
DR   InterPro; IPR013078; PG_mutase.
DR   PANTHER; PTHR10606; 6Pfruct_kin; 1.
DR   Pfam; PF01591; 6PF2K; 1.
DR   Pfam; PF00300; PGAM; 1.
DR   PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR   PRINTS; PR00991; 6PFRUCTKNASE.
DR   SMART; SM00855; PGAM; 1.
DR   PROSITE; PS00175; PG_MUTASE; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q9ESY2.
DR   SWISS-2DPAGE; Q9ESY2.
KW   Kinase.
FT   DOMAIN        1     39       PRODOM:2005.1:PDA1E222  5
FT   DOMAIN       41    247       PRODOM:2005.1:PD324818  79
FT   DOMAIN      254    449       PRODOM:2005.1:PD858890  96
SQ   SEQUENCE   520 AA;  59701 MW;  3958F16471A7D84D CRC64;
     MPLELTQSRV QKIWVPVDHR PSLPRSCGPK LTNSPTVIVM VGLPARGKTY ISKKLTRYLN
     WIGVPTKVFN VGEYRREAVK QYSSYNFFRP DNEEAMRVRK QCALAALRDV KSYLTKEGGQ
     IAVFDATNTT RERRHMILNF AKENDFKAFF IESVCDDPTV VASNIMEVKI SSPDYKDCNS
     AEAMDDFMKR INCYEASYQP LDPDKCDRDL SLIKVIDVGR RFLVNRVQDH IQSRIVYYLM
     NIHVQPRTIY LCRHGENEYN LQGKIGGDSS LSSRGKKFAN ALSKFVEEQN LKDLRVWTSQ
     LKSTIQTAEA LRLPYEQWKA LNEIDAGVCE ELTYEEIRDT YPEEYALREQ DKYYYRYPTG
     ESYQDLVQRL EPVIMELERQ ENVLVICHQA VLRCLLAYFL DKSAEEMPYL KCPLHTVLKL
     TPVAYGCRVE SIYLNVESVS THRERSEDAK KGPNPLMRRN SVTPLASPEP TKKPRINSFE
     ERVASTSAAL PSCLPPEVPT QLPGQNMKSS RSGADSSQKH
//

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