(data stored in ACNUC4266 zone)

HOVERGEN: RAB2A_MACFA

ID   RAB2A_MACFA             Reviewed;         212 AA.
AC   Q4R4X6;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2005, sequence version 1.
DT   13-OCT-2009, entry version 38.
DE   RecName: Full=Ras-related protein Rab-2A;
GN   Name=RAB2A; Synonyms=RAB2; ORFNames=QtrA-12017, QtsA-19013;
OS   Macaca fascicularis (Crab eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex, and Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for protein transport from the endoplasmic
CC       reticulum to the Golgi complex (By similarity).
CC   -!- SUBUNIT: Interacts with PRKCI (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum-Golgi intermediate
CC       compartment membrane; Lipid-anchor (By similarity). Melanosome (By
CC       similarity). Endoplasmic reticulum membrane; Lipid-anchor (By
CC       similarity). Golgi apparatus membrane; Lipid-anchor (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Rab family.
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CC   -!- GENE_FAMILY: HBG009351 [ FAMILY / ALN / TREE ]
DR   EMBL; AB169319; BAE01404.1; -; mRNA.
DR   EMBL; AB169768; BAE01849.1; -; mRNA.
DR   SMR; Q4R4X6; 2-170.
DR   HOVERGEN; Q4R4X6; -.
DR   GO; GO:0031225; C:anchored to membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-KW.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-KW.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR003579; GTPase_Rab.
DR   InterPro; IPR013753; Ras.
DR   InterPro; IPR001806; Ras_GTPase.
DR   InterPro; IPR005225; Small_GTP_bd.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00175; RAB; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51419; RAB; 1.
PE   2: Evidence at transcript level;
DR   PRODOM; Q4R4X6.
DR   SWISS-2DPAGE; Q4R4X6.
KW   Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   GTP-binding; Lipoprotein; Membrane; Nucleotide-binding; Prenylation;
KW   Protein transport; Transport.
FT   CHAIN         1    212       Ras-related protein Rab-2A.
FT                                /FTId=PRO_0000253742.
FT   NP_BIND      13     20       GTP (By similarity).
FT   NP_BIND      61     65       GTP (By similarity).
FT   NP_BIND     119    122       GTP (By similarity).
FT   REGION        1     19       Required for interaction with PRKCI (By
FT                                similarity).
FT   MOTIF        35     43       Effector region (By similarity).
FT   LIPID       211    211       S-geranylgeranyl cysteine (By
FT                                similarity).
FT   LIPID       212    212       S-geranylgeranyl cysteine (By
FT                                similarity).
SQ   SEQUENCE   212 AA;  23546 MW;  F8731E3F8FB399A3 CRC64;
     MAYAYLFKYI IIGDTGVGKS CLLLQFTDKR FQPVHDLTIG VEFGARMITI DGKQIKLQIW
     DTAGQESFRS ITRSYYRGAA GALLVYDITR RDTFNHLTTW LEDARQHSNS NMVIMLIGNK
     SDLESRREVK KEEGEAFARE HGLIFMETSA KTASNVEEAF INTAKEIYEK IQEGVFDINN
     EANGIKIGPQ HAATNATHAG NQGGQQAGGG CC
//

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