(data stored in ACNUC15468 zone)

HOGENOM: RABIT14_84_PE10

ID   RABIT14_84_PE10                      STANDARD;      PRT;   905 AA.
AC   RABIT14_84_PE10; P51789;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Chloride channel protein 2; Short=ClC-2;AltName:
DE   Full=PKA-activated chloride channel; (RABIT14_84.PE10).
GN   Name=CLCN2;
OS   ORYCTOLAGUS CUNICULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RABIT14_84.PE10.
CC       Oryctolagus cuniculus chromosome 14 oryCun2 partial sequence
CC       81100393..82100392 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN2_RABIT
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport. May be involved in gastric HCl
CC       secretion.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Ubiquitously expressed (Probable).
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The absence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as channels (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-2/CLCN2 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Oryctolagus_cuniculus;ENSOCUG00000007065;ENSOCUT00000007070;ENSOCUP00000006115.
DR   EMBL; S80361; - ;
DR   EMBL; U15652; - ;
DR   UniProtKB/Swiss-Prot; P51789; -.
DR   EMBL; U15652; AAB05937.1; -; mRNA.
DR   RefSeq; NP_001076220.1; NM_001082751.1.
DR   UniGene; Ocu.2428; -.
DR   ProteinModelPortal; P51789; -.
DR   STRING; P51789; -.
DR   Ensembl; ENSOCUT00000007070; ENSOCUP00000006115; ENSOCUG00000007065.
DR   GeneID; 100009530; -.
DR   CTD; 1181; -.
DR   eggNOG; maNOG12530; -.
DR   OrthoDB; EOG4G7BXQ; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   InterPro; IPR002244; Cl-channel-2.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 1.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01113; CLCHANNEL2.
DR   SMART; SM00116; CBS; 1.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; RABIT14_84.PE10; -.
KW   ENSOCUG00000007065820036002503210000011;
KW   CLCN2_RABIT; Q6LD51_RABIT; S80361; U15652;
KW   CBS domain; Chloride; Chloride channel; Ion transport; Ionic channel;
KW   Membrane; Repeat; Transmembrane; Transmembrane helix; Transport;
KW   Voltage-gated channel.
SQ   SEQUENCE   905 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     AEMAAPAAAA VEEGMEPRAL QYEQTLMYGR YTQDLGAFAK EEAARIRLGG PEPWRSPPSP
     RTPPELLEYG QSRCARCRMC SVRCHKFLVS RVGEDWIFLV LLGLLMALVS WAMDYAIAAC
     LQAQQWMSRG LNTNLLLQYL AWVTYPVVLI TFSAGFTQIL APQAVGSGIP EMKTILRGVV
     LKEYLTLKTF VAKVIGLTCA LGSGMPLGKE GPFVHIASMC AALLSKFLSL FGGIYENESR
     NTEMLAAACA VGVGCCFAAP IGGVLFSIEV TSTFFAVRNY WRGFFAATFS AFIFRVLAVW
     NRDEETITAL FKTRFRLDFP FDLQELPAFA VIGIASGFGG ALFVYLNRKI VQVMRKQKTI
     NRFLMRKRLL FPALVTLLIS TLTFPPGFGQ FMAGQLSQKE TLVTLFDNRT WVRQGLVEEL
     EPPSTSQAWS PPRANVFLTL VIFILMKFWM SALATTIPVP CGAFMPVFVI GAAFGRLVGE
     SMAAWFPDGI HTDSSTYRIV PGGYAVVGAA ALAGAVTHTV STAVIVFELT GQIAHILPVM
     IAVILANAVA QSLQPSLYDS IIRIKKLPYL PELGWGRHQQ YRVRVEDIMV RDVPHVALSC
     TFRDLRLALH RTKGRTLALV ESPESMILLG SIERTQVVAL LAAQLSPARR RQSKQKRRVA
     HTSPPSCQES PPSPETSVCF QVREKPQGRT GFLGEPHKPL KPALKRGCSN SVNLGESPTG
     HVESAGIALR SLFCGSPPPE AASESEKSES SEKRKSKRVR ISLASDSDLE GEMSPEEILE
     WEEQQLDEPV NFSDCKIDPA PFQLVERTSL HKTHTIFSLL GVDHAYVTSI GRLIGIVTLK
     ELRKAIEGSV TAQGVKVRPP LASFRDSATS SSDTETTEVH ALWGPRSRHG LPREGSPSDS
     DDKCQ
//

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