(data stored in ACNUC8465 zone)

HOGENOM: RABIT17_7_PE7

ID   RABIT17_7_PE7                        STANDARD;      PRT;   394 AA.
AC   RABIT17_7_PE7; P29678;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 1;
DE   Short=MAP kinase kinase 1; Short=MAPKK 1; EC=2.7.12 2;AltName: Full=ERK
DE   activator kinase 1;AltName: Full=MAPK/ERK kinase 1; Short=MEK 1;
DE   (RABIT17_7.PE7).
GN   Name=MAP2K1; Synonyms=MEK1, PRKMK1;
OS   ORYCTOLAGUS CUNICULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RABIT17_7.PE7.
CC       Oryctolagus cuniculus chromosome 17 oryCun2 partial sequence
CC       5667282..6667281 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K1_RABIT
CC   -!- FUNCTION: Catalyzes the concomitant phosphorylation of a threonine
CC       and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP
CC       kinases. Activates ERK1 and ERK2 MAP kinases.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- SUBUNIT: Interacts with MORG1. Interacts with ARRB2. Found in a
CC       complex with at least BRAF, HRAS1, MAP2K1, MAPK3 and RGS14 (By
CC       similarity).
CC   -!- PTM: MAPKK is itself dependent on Ser/Thr phosphorylation for
CC       activity catalyzed by MAP kinase kinase kinases (RAF or MEKK1).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Oryctolagus_cuniculus;ENSOCUG00000008782;ENSOCUT00000008781;ENSOCUP00000007582.
DR   EMBL; Z30163; - ;
DR   UniProtKB/Swiss-Prot; P29678; -.
DR   EMBL; Z30163; CAA82912.1; -; mRNA.
DR   PIR; S42068; S42068.
DR   RefSeq; NP_001076098.1; NM_001082629.1.
DR   UniGene; Ocu.3187; -.
DR   PDB; 2Y4I; X-ray; 3.46 A; C=1-393.
DR   PDBsum; 2Y4I; -.
DR   ProteinModelPortal; P29678; -.
DR   SMR; P29678; 62-382.
DR   IntAct; P29678; 1.
DR   STRING; P29678; -.
DR   Ensembl; ENSOCUT00000008781; ENSOCUP00000007582; ENSOCUG00000008782.
DR   GeneID; 100009316; -.
DR   CTD; 5604; -.
DR   eggNOG; maNOG09203; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   OrthoDB; EOG4SF965; -.
DR   BRENDA; 2.7.12.2; 1749.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005515; F:protein binding; IPI:IntAct.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RABIT17_7.PE7; -.
KW   ENSOCUG00000008782820036002503210000011;
KW   MP2K1_RABIT; Z30163;
KW   3D-structure; ATP-binding; Direct protein sequencing; Kinase;
KW   Nucleotide-binding; Phosphoprotein; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   394 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSRRKPPTSP LRCHPCKTHN SQPSPHPRSP TNLEALQKKL EELELDEQQR KRLEAFLTQK
     QKVGELKDDD FEKISELGAG NGGVVFKVSH KPSGLVMARK LIHLEIKPAI RNQIIRELQV
     LHECNSPYIV GFYGAFYSDG EISICMEHMD GGSLDQVLKK AGRIPEQILG KVSIAVIKGL
     TYLREKHKIM HRDVKPSNIL VNSRGEIKLC DFGVSGQLID SMANSFVGTR SYMSPERLQG
     THYSVQSDIW SMGLSLVEMA VGRYPIPPPD AKELELMFGC QVEGDAAETP PRPRTPGRPL
     SSYGMDSRPP MAIFELLDYI VNEPPPKLPS AVFSLEFQDF VNKCLIKNPA ERADLKQLMV
     HAFIKRSDAE EVDFAGWLCS TIGLNQPSTP THAA
//

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