(data stored in ACNUC10083 zone)

HOGENOM: RABITUN0041_3_PE10

ID   RABITUN0041_3_PE10                   STANDARD;      PRT;   869 AA.
AC   RABITUN0041_3_PE10; Q9TT16;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride transport protein 6;AltName: Full=Chloride channel
DE   protein 6; Short=ClC-6; (RABITUN0041_3.PE10).
GN   Name=CLCN6;
OS   ORYCTOLAGUS CUNICULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RABITUN0041_3.PE10.
CC       Oryctolagus cuniculus chromosome Un0041 oryCun2 partial sequence
CC       1967559..2331373 annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN6_RABIT
CC   -!- FUNCTION: Chloride transport protein, initially identified as
CC       voltage-gated chloride channel. The presence of the conserved
CC       gating glutamate residues suggests that is functions as antiporter
CC       (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endosome membrane; Multi-pass membrane
CC       protein (By similarity).
CC   -!- PTM: N-glycosylated on several asparagine residues (By
CC       similarity).
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The presence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as antiporters (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-6/CLCN6 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231081 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Oryctolagus_cuniculus;ENSOCUG00000007298;ENSOCUT00000007301;ENSOCUP00000006313.
DR   EMBL; AF209724; - ;
DR   UniProtKB/Swiss-Prot; Q9TT16; -.
DR   EMBL; AF209724; AAF22834.1; -; mRNA.
DR   RefSeq; NP_001075543.1; NM_001082074.1.
DR   UniGene; Ocu.2410; -.
DR   ProteinModelPortal; Q9TT16; -.
DR   Ensembl; ENSOCUT00000007301; ENSOCUP00000006313; ENSOCUG00000007298.
DR   GeneID; 100008750; -.
DR   CTD; 1185; -.
DR   GeneTree; ENSGT00550000074179; -.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002248; Cl_channel-6.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01117; CLCHANNEL6.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; RABITUN0041_3.PE10; -.
KW   ENSOCUG00000007298820036002503210000011;
KW   CLCN6_RABIT; AF209724;
KW   Antiport; ATP-binding; CBS domain; Chloride; Endosome; Glycoprotein;
KW   Ion transport; Membrane; Nucleotide-binding; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
SQ   SEQUENCE   869 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGCRGSLCC CCRWCCCCGE RETRTPEELT ILGETQEEED EILPRKDYES LDYDRCINDP
     YLEVLETMDH KKGRWYEVVK WTVVFAIGVC TGLVSSGAEL MVGQRQAPKF GVVEAPVEEC
     SQKGCLALSL LELLGFNLTF VFLASLLVLI EPVAAGSGIP EIKCYLNGVK VPGIVRLRTL
     LCKVFGVLFS VAGGLFVGKE GPMIHSGAVV GAGLPQFQSI SLRKIQFNFP YFRSDRDKRD
     FVSAGAAAGI AAAFGAPIGA TLFSLEEGSS FWNQGLTWKV LFCSMSATFT LNFFRSGIQF
     GSWGSFQLPG LLNFGEFKCS DSDKKCHLWT AMDMGFFVVM GVIGGLLGAT FNCLNKRLAK
     YRMRNVHPKP KLVRVLESLL VSLVTTLVVF VASMVLGECR QMSSSSQISN GSLKLQVTSD
     VNSSIKAFFC PNDTYNDMAT LFFNPQESAI LQLFHQDGTF SPITLALFFV LYFLLACWTY
     GISVPSGLFV PSLLCGAAFG RLVANVLKSY IGLSHIYSGT FSLIGAAALL GGVVRMTISL
     TVILIESTNE ITYGLPIMIT LMVAKWTGDF FNKGIYDIHV GLRGVPLLEW ETEVEMDKLR
     ASDIMEPNLT YVYPHTRIQS LVSILRTTVH HAFPVVTENR GNEKEFMKGN QLISNNIKFK
     KSSILTRAGE QRRRSQSMKS YPSSELRNMC DEHVASEEPA EKEDLLQQML ERRYTPYPNL
     YPDQSPSEDW TMEERFRPLT FHGLILRSQL VTLLVRGVCY SESQSSASQP RLSYAEMAED
     YPRFPDIHDL DLTLLNPRMI VDVTPYMNPS PFTVSPNTHV SQVFNLFRTM GLRHLPVVNA
     VGEIVGIVTR HNLTYEFLQA RLRQHYQSL
//

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