(data stored in ACNUC15468 zone)

HOGENOM: RABITUN0093_1_PE13

ID   RABITUN0093_1_PE13                   STANDARD;      PRT;   687 AA.
AC   RABITUN0093_1_PE13; P51803;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel protein ClC-Ka; Short=Chloride channel
DE   Ka;AltName: Full=ClC-K1; (RABITUN0093_1.PE13).
GN   Name=CLCNKA;
OS   ORYCTOLAGUS CUNICULUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RABITUN0093_1.PE13.
CC       Oryctolagus cuniculus chromosome Un0093 oryCun2 partial sequence 1..100
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCKA_RABIT
CC   -!- FUNCTION: Voltage-gated chloride channel. Chloride channels have
CC       several functions including the regulation of cell volume;
CC       membrane potential stabilization, signal transduction and
CC       transepithelial transport. May be important in urinary
CC       concentrating mechanisms.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed predominantly in the kidney.
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       CLCNKA subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231297 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Oryctolagus_cuniculus;ENSOCUG00000008729;ENSOCUT00000024516;ENSOCUP00000024619.
DR   EMBL; U36789; - ;
DR   EMBL; U36790; - ;
DR   UniProtKB/Swiss-Prot; P51803; -.
DR   EMBL; U36789; AAC48492.1; -; mRNA.
DR   RefSeq; NP_001075830.1; NM_001082361.1.
DR   UniGene; Ocu.2275; -.
DR   ProteinModelPortal; P51803; -.
DR   SMR; P51803; 542-687.
DR   Ensembl; ENSOCUT00000024516; ENSOCUP00000024619; ENSOCUG00000008729.
DR   GeneID; 100009213; -.
DR   CTD; 1187; -.
DR   eggNOG; maNOG06130; -.
DR   OrthoDB; EOG4KD6KM; -.
DR   GO; GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002250; Cl_channel-K.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 1.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01119; CLCHANNELKDY.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; RABITUN0093_1.PE13; -.
KW   ENSOCUG00000008729820036002503210000011;
KW   CLCKA_RABIT; CLCKB_RABIT; U36789; U36790;
KW   CBS domain; Chloride; Chloride channel; Ion transport; Ionic channel;
KW   Membrane; Phosphoprotein; Repeat; Transmembrane; Transmembrane helix;
KW   Transport; Voltage-gated channel.
SQ   SEQUENCE   687 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEELVGLREG SSGNPVALRE LWGPCPRLRR GIRGGLEWLK QKLFRVGEDW YFLMTLGVLM
     ALISYAMNFA LGRVVRAHKW LYREIGDSHL LRYLSWTVYP VALVSFSSGF SQSITPFSGG
     SGIPELKTIL SGVVLENYLD IKNFGAKVVG LSCTLATGST LFLGKVGPFV HLSVMIAAYL
     GRVRTKTIGE AENKSKQNEM LVAGAAVGVA TVFAAPFSGV LFCIEVMSSH FSVWDYWRGF
     FAATCGAFMF RLLAVFNSEQ ETITSLYKTS FPVDVPFDLP EIFFFVLLGA ICGVASCAYL
     YCQRTFLAFT KTNKLISKLM ATSKPLYAAL AATVLASITY PPGVGRFMAS RLSMREHLDT
     LFDNHSWALL TRNSSPPWPA EPDPQHLWWE WYHPRFTIFG TLAFFLVMKF WMLILATTIP
     MPAGYFLPIF IIGAAIGRLL GEALSVAFPE GIVAGGVINP IMPGGYALAG AAAFSGAVTH
     SISTALLAFE LTGQIVHALP VLMAVLAANA IAQSCQPSFY DGTIMVKKLP YLPWIRGRPI
     NSHRVIVEHF MRRAISTLAR DAALEQVVKV LTSTDEAEYP LVESTESQLL VGIVQRAQLV
     QALQAEAPAR ASGQQRCLQD ILAGGCPTEP VTLTLSPETS LHQAHNLFEL LNLRSLYVTS
     KGRAVGYVSW VELEKAISAL TNPPAAK
//

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