(data stored in ACNUC4266 zone)

HOVERGEN: RAS_CARAU

ID   RAS_CARAU               Reviewed;         183 AA.
AC   P05774; Q90W85;
DT   01-NOV-1988, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1988, sequence version 1.
DT   13-OCT-2009, entry version 69.
DE   RecName: Full=Ras-like protein;
DE   Flags: Fragment;
OS   Carassius auratus (Goldfish).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Carassius.
OX   NCBI_TaxID=7957;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Wakin; TISSUE=Liver;
RX   MEDLINE=87054992; PubMed=3023161;
RX   DOI=10.1111/j.1432-0436.1986.tb00551.x;
RA   Nemoto N., Kodama K., Tazawa A., Masahito P., Ishikawa T.;
RT   "Extensive sequence homology of the goldfish ras gene to mammalian ras
RT   genes.";
RL   Differentiation 32:17-23(1986).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.
RC   TISSUE=Liver;
RX   MEDLINE=87137862; PubMed=3029139; DOI=10.1007/BF00389967;
RA   Nemoto N., Kodama K., Tazawa A., Matsumoto J., Masahito P.,
RA   Ishikawa T.;
RT   "Nucleotide sequence comparison of the predicted first exonic region
RT   of goldfish ras gene between normal and neoplastic tissues.";
RL   J. Cancer Res. Clin. Oncol. 113:56-60(1987).
CC   -!- FUNCTION: Ras proteins bind GDP/GTP and possess intrinsic GTPase
CC       activity.
CC   -!- ENZYME REGULATION: Alternate between an inactive form bound to GDP
CC       and an active form bound to GTP. Activated by a guanine
CC       nucleotide-exchange factor (GEF) and inactivated by a GTPase-
CC       activating protein (GAP).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic
CC       side (Potential).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
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CC   -!- GENE_FAMILY: HBG009351 [ FAMILY / ALN / TREE ]
DR   EMBL; M26734; AAA49189.1; -; Genomic_DNA.
DR   EMBL; M26732; AAA49189.1; JOINED; Genomic_DNA.
DR   EMBL; M26733; AAA49189.1; JOINED; Genomic_DNA.
DR   EMBL; X12878; CAA31371.1; -; Genomic_DNA.
DR   EMBL; M38485; AAA49188.1; -; Genomic_DNA.
DR   EMBL; M38486; AAA62759.1; -; Genomic_DNA.
DR   PIR; S05483; S05483.
DR   PIR; S06217; S06217.
DR   HSSP; P01112; 1PLL.
DR   SMR; P05774; 1-166.
DR   HOVERGEN; P05774; -.
DR   GO; GO:0009898; C:internal side of plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005622; C:intracellular; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR003577; GTPase_Ras.
DR   InterPro; IPR013753; Ras.
DR   InterPro; IPR001806; Ras_GTPase.
DR   InterPro; IPR015592; Ras_Ras_related.
DR   InterPro; IPR005225; Small_GTP_bd.
DR   PANTHER; PTHR11708:SF125; Ras_Ras_related; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
PE   3: Inferred from homology;
DR   PRODOM; P05774.
DR   SWISS-2DPAGE; P05774.
KW   Cell membrane; GTP-binding; Lipoprotein; Membrane; Nucleotide-binding;
KW   Prenylation.
FT   CHAIN         1   >183       Ras-like protein.
FT                                /FTId=PRO_0000082658.
FT   NP_BIND      10     17       GTP (By similarity).
FT   NP_BIND      57     61       GTP (By similarity).
FT   NP_BIND     116    119       GTP (By similarity).
FT   MOTIF        32     40       Effector region (By similarity).
FT   NON_TER     183    183
SQ   SEQUENCE   183 AA;  21043 MW;  BDF1A556C36CDB8F CRC64;
     MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG
     QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL
     PSRSVDTKQA QDLARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLRK LSKEEETTQC
     IKL
//

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