(data stored in ACNUC14238 zone)

HOGENOM: RAT10_PE1

ID   RAT10_PE1                            STANDARD;      PRT;   293 AA.
AC   RAT10_PE1; Q5PQN2;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Bifunctional apoptosis regulator; (RAT10.PE1).
GN   Name=Bfar;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE1.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:BFAR_RAT
CC   -!- FUNCTION: Apoptosis regulator. Has anti-apoptotic activity, both
CC       for apoptosis triggered via death-receptors and via mitochondrial
CC       factors (By similarity).
CC   -!- SUBUNIT: Interacts with CASP8, BCL2 and BCL2L1 through SAM domain
CC       and also with HIP1, IFT57, ESRRBL1 and BCAP31 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- SIMILARITY: Contains 1 RING-type zinc finger.
CC   -!- SIMILARITY: Contains 1 SAM (sterile alpha motif) domain.
CC   -!- GENE_FAMILY: HOG000285958 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000003151;ENSRNOT00000004217;ENSRNOP00000004217.
DR   EMBL; BC087103; - ;
DR   UniProtKB/Swiss-Prot; Q5PQN2; -.
DR   EMBL; BC087103; AAH87103.1; -; mRNA.
DR   IPI; IPI00198735; -.
DR   RefSeq; NP_001013143.1; NM_001013125.1.
DR   UniGene; Rn.159939; -.
DR   ProteinModelPortal; Q5PQN2; -.
DR   SMR; Q5PQN2; 170-248.
DR   STRING; Q5PQN2; -.
DR   PRIDE; Q5PQN2; -.
DR   GeneID; 304709; -.
DR   KEGG; rno:304709; -.
DR   CTD; 51283; -.
DR   RGD; 1304791; Bfar.
DR   eggNOG; maNOG09043; -.
DR   GeneTree; ENSGT00390000005386; -.
DR   InParanoid; Q5PQN2; -.
DR   OrthoDB; EOG4N5VWT; -.
DR   NextBio; 653497; -.
DR   ArrayExpress; Q5PQN2; -.
DR   Genevestigator; Q5PQN2; -.
DR   GermOnline; ENSRNOG00000003151; Rattus norvegicus.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed.
DR   InterPro; IPR021129; SAM_type1.
DR   InterPro; IPR018957; Znf_C3HC4_RING-type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   Gene3D; G3DSA:1.10.150.50; SAM_type; 1.
DR   Gene3D; G3DSA:3.30.40.10; Znf_RING/FYVE/PHD; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF00097; zf-C3HC4; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00454; SAM; 1.
DR   SUPFAM; SSF47769; SAM_homology; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   HOGENOMDNA; RAT10.PE1; -.
KW   ENSRNOG00000003151820036002503210000011;
KW   Bfar; BFAR_RAT; BC087103;
KW   Apoptosis; Complete proteome; Endoplasmic reticulum; Glycoprotein;
KW   Membrane; Metal-binding; Phosphoprotein; Reference proteome;
KW   Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
SQ   SEQUENCE   293 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     ILLVYHWRSR ESEHGLLVHK AVYKWTTEEV VLWLEQLGPW ASLYRDRFLS ERVNGRLLLT
     LTEEEFSRAP YTIENSSHRR VILMELERVR ALGVKPPQNL WEYKAVNPGR SLFLLYALKS
     SPRLGLLYLY LFDYTDSFLP FIHTICPLQE DSFGEDIFTK LLDLREPTWK QWREFLIKYS
     FLPYQLIAEF AWDWLEVHYW TSRFLIVNAM LLSVLELFSF WRIWSRSELK TVPQRMWSHF
     WKVSTQGLFM AMFWPLIPQF VCNCLFYWAL YFNPIINIDL VVKEIRRLET QVF
//

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