(data stored in ACNUC14238 zone)

HOGENOM: RAT10_PE10

ID   RAT10_PE10                           STANDARD;      PRT;   1331 AA.
AC   RAT10_PE10; Q63862; Q58GJ0; Q63338; Q63339; Q63861;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Myosin-11;AltName: Full=Myosin heavy chain 11;AltName:
DE   Full=Myosin heavy chain, smooth muscle isoform;AltName: Full=SMMHC;Flags:
DE   Fragments; (RAT10.PE10).
GN   Name=Myh11;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE10.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MYH11_RAT
CC   -!- FUNCTION: Muscle contraction.
CC   -!- SUBUNIT: Muscle myosin is a hexameric protein that consists of 2
CC       heavy chain subunits (MHC), 2 alkali light chain subunits (MLC)
CC       and 2 regulatory light chain subunits (MLC-2).
CC   -!- SUBCELLULAR LOCATION: Melanosome (By similarity). Cytoplasm,
CC       myofibril. Note=Thick filaments of the myofibrils.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1; Synonyms=SM1B;
CC         IsoId=Q63862-1; Sequence=Displayed;
CC       Name=2; Synonyms=SM1A;
CC         IsoId=Q63862-2; Sequence=VSP_050914;
CC       Name=3; Synonyms=SM2;
CC         IsoId=Q63862-3; Sequence=VSP_050915;
CC   -!- TISSUE SPECIFICITY: Both isoform 1 and isoform 2 are detected in
CC       small and large intestine, uterus, bladder, aorta, stomach, and at
CC       much lower levels in lung. All three isoforms are coexpressed in
CC       smooth muscle. Isoform 2 predominates in most of the smooth
CC       muscles tested, with the exception of intestine and urinary
CC       bladder, which show greater expression of isoform 1.
CC   -!- DOMAIN: The rodlike tail sequence is highly repetitive, showing
CC       cycles of a 28-residue repeat pattern composed of 4 heptapeptides,
CC       characteristic for alpha-helical coiled coils.
CC   -!- DOMAIN: Each myosin heavy chain can be split into 1 light
CC       meromyosin (LMM) and 1 heavy meromyosin (HMM). It can later be
CC       split further into 2 globular subfragments (S1) and 1 rod-shaped
CC       subfragment (S2).
CC   -!- SIMILARITY: Contains 1 IQ domain.
CC   -!- SIMILARITY: Contains 1 myosin head-like domain.
CC   -!- GENE_FAMILY: HOG000173958 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000000029;ENSRNOT00000030661;ENSRNOP00000030152.
DR   EMBL; AY953023; - ;
DR   EMBL; S61948; - ;
DR   EMBL; X16261; - ;
DR   EMBL; X16262; - ;
DR   UniProtKB/Swiss-Prot; Q63862; Q58GJ0; Q63338; Q63339; Q63861; -.
DR   EMBL; AY953023; AAX51987.1; -; mRNA.
DR   EMBL; S61948; AAB26775.1; -; mRNA.
DR   EMBL; X16261; CAA34347.1; -; mRNA.
DR   EMBL; X16262; CAA34348.1; -; mRNA.
DR   IPI; IPI00464464; -.
DR   IPI; IPI00464465; -.
DR   IPI; IPI00896783; -.
DR   PIR; S07537; S07537.
DR   PIR; S10450; S10450.
DR   UniGene; Rn.94969; -.
DR   ProteinModelPortal; Q63862; -.
DR   SMR; Q63862; 1-676.
DR   STRING; Q63862; -.
DR   PhosphoSite; Q63862; -.
DR   PRIDE; Q63862; -.
DR   RGD; 3136; Myh11.
DR   eggNOG; roNOG11109; -.
DR   GeneTree; ENSGT00580000081235; -.
DR   PhylomeDB; Q63862; -.
DR   ArrayExpress; Q63862; -.
DR   Genevestigator; Q63862; -.
DR   GermOnline; ENSRNOG00000000029; Rattus norvegicus.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005859; C:muscle myosin complex; NAS:UniProtKB.
DR   GO; GO:0030016; C:myofibril; IEA:UniProtKB-SubCell.
DR   GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0003774; F:motor activity; IEA:InterPro.
DR   GO; GO:0008307; F:structural constituent of muscle; NAS:UniProtKB.
DR   GO; GO:0006939; P:smooth muscle contraction; NAS:UniProtKB.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001609; Myosin_head_motor_dom.
DR   InterPro; IPR002928; Myosin_tail.
DR   Pfam; PF00063; Myosin_head; 1.
DR   Pfam; PF01576; Myosin_tail_1; 1.
DR   PRINTS; PR00193; MYOSINHEAVY.
DR   SMART; SM00015; IQ; 1.
DR   SMART; SM00242; MYSc; 1.
DR   PROSITE; PS50096; IQ; 1.
DR   HOGENOMDNA; RAT10.PE10; -.
KW   ENSRNOG00000000029820036002503210000011;
KW   MYH11_RAT; AY953023; S61948; X16261; X16262;
KW   Actin-binding; Alternative splicing; ATP-binding; Calmodulin-binding;
KW   Coiled coil; Complete proteome; Cytoplasm; Motor protein;
KW   Muscle protein; Myosin; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Thick filament.
SQ   SEQUENCE   1331 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MYKGKKRHEM PPHIYAIADT AYRSMLQDRE DQSILCTGES GAGKTENTKK VIQYLAVVAS
     SHKGKKDSSI TQGPSFAYGE LEKQLLQANP ILEAFGNAKT VKNDNSSRFG KFIRINFDVT
     GYIVGANIET YLLEKSRAIR QARDERTFHI FYYLIAGAKE KMRNDLLLES FNSYTFLSNG
     FVPIPAAQDD EMFQETLEAM SIMGFSEEEQ LAILKVVSSV LQLGNIVFKK ERNTDQASMP
     DNTAAQKVCH LVGINVTDFT RAILTPRIKV GRDVVQKAQT KEQADFAIEA LAKATYERLF
     RWILSRVNKA LDKTHRQGAS FLGILDIAGF EIFEVNSFEQ LCINYTNEKL QQLFNHTMFI
     LEQEEYQREG IEWNFIDFGL DLQPCIELIE RPNNPPGVLA LLDEECWFPK ATDKSFVEKL
     CSEQGNHPKF QKPKQLKDKT EFSIIHYAGK VDYNASAWLT KNMDPLNDNV TSLLNASSDK
     FVADLWKDVD RIVGLDQMAK MTESSLPSAS KTKKGMFRTV GQLYKEQLGK LMTTLRNTTP
     NFVRCIIPNH EKRSGKLDAF LVLEQLRCNG VLEGIRICRQ GFPNRIVFQE FRQRYEILAA
     NAIPKGFMDG KQACILMIKA LELDPNLYRI GQSKIFFRTG VLAHLEEERD LKITDVIMAF
     QAMCRGYLAR KAFTKRQQQL TAMKVIQRNC AAYLKLRNWQ WWRLFTKVRP LDEEMEAKQN
     LERHVSTLNI QLSDSKKKLQ DLASTIEVME EGKKRLQKEM EGLGQQYEEK AAAYDKLEKT
     KNRLQQELDD LVVDLDNQRQ LVSNLEKKQK KFDQLLAEEK NISSKYADER DRAEAEAREK
     ETKALSLARA LEEALEAKEE LERTNKMLKA EMEDLVSSKD DVGKNVHELE KSKRALETQM
     EEMRTQLEEL EDELQATEDA KLRLEVNMQA LKGQFERDLQ ARDEQNEEKR RQLQRQLHEY
     ETELEDERKQ RALAAAAKKK LEGDLKDLEL QADSAVKGRE EAIKQLRKLQ AQMKDFQREL
     DDARASRDEI FATSKENEKK AKSLEAELMQ LQEDLAAAER ARKQADLEKE ELAEELASSL
     SGRNTLQDEK RRLEARIAQL EEELEEEQGN MEAMSDRVRK ATLQAEQLSN ELVTERSAAQ
     KNESARQQLE RQNKELRSKL QEVEGAVKAK LKSTVAALEA KIVQLEEQIE QEAREKQAAT
     KLLKQKDKKL KEVLLQVEDE RKMVEQYKEQ AEKGNTKVKQ LKRQLEEAEE ESQRINANRR
     KLQRELDEAT ESNEAMGREV NALKSKLRRG NEASFVPSRR AGGRRVIENT DGSEEEMDAR
     DSDFNGTKAS E
//

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