(data stored in ACNUC14238 zone)

HOGENOM: RAT10_PE1010

ID   RAT10_PE1010                         STANDARD;      PRT;   236 AA.
AC   RAT10_PE1010; Q9Z2Q7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Syntaxin-8; (RAT10.PE1010).
GN   Name=Stx8;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE1010.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:STX8_RAT
CC   -!- FUNCTION: Vesicle trafficking protein that functions in the early
CC       secretory pathway, possibly by mediating retrograde transport from
CC       cis-Golgi membranes to the ER.
CC   -!- SUBUNIT: Part of the SNARE core complex containing STX7, VAMP8 and
CC       VTI1B. Interacts with VAMP8. Forms a SNARE complex with STX7,
CC       VTI1B and VAMP8 which functions in the homotypic fusion of late
CC       endosomes. Component of the SNARE complex composed of STX7, STX8,
CC       VAMP7 and VTI1B that is required for heterotypic fusion of late
CC       endosomes with lysosomes in liver cells. Interacts with HECTD3 (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type IV membrane
CC       protein. Note=Preferentially associated with the early endosome.
CC       To lesser extends, also present in late endosome, the plasma
CC       membrane and coated pits.
CC   -!- TISSUE SPECIFICITY: Widely expressed in all tissues examined.
CC   -!- PTM: Ubiquitinated by HECTD3 (By similarity).
CC   -!- SIMILARITY: Belongs to the syntaxin family.
CC   -!- SIMILARITY: Contains 1 t-SNARE coiled-coil homology domain.
CC   -!- GENE_FAMILY: HOG000031515 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000003849;ENSRNOT00000005204;ENSRNOP00000005204.
DR   EMBL; AF033109; - ;
DR   UniProtKB/Swiss-Prot; Q9Z2Q7; -.
DR   EMBL; AF033109; AAC70903.1; -; mRNA.
DR   IPI; IPI00210157; -.
DR   RefSeq; NP_113844.1; NM_031656.1.
DR   UniGene; Rn.20291; -.
DR   PDB; 1GL2; X-ray; 1.90 A; D=149-209.
DR   PDBsum; 1GL2; -.
DR   ProteinModelPortal; Q9Z2Q7; -.
DR   SMR; Q9Z2Q7; 152-205.
DR   STRING; Q9Z2Q7; -.
DR   PRIDE; Q9Z2Q7; -.
DR   Ensembl; ENSRNOT00000005204; ENSRNOP00000005204; ENSRNOG00000003849.
DR   GeneID; 59074; -.
DR   KEGG; rno:59074; -.
DR   UCSC; NM_031656; rat.
DR   CTD; 9482; -.
DR   RGD; 61917; Stx8.
DR   eggNOG; roNOG06719; -.
DR   GeneTree; ENSGT00390000007779; -.
DR   InParanoid; Q9Z2Q7; -.
DR   OMA; QKIIQEQ; -.
DR   OrthoDB; EOG402WT8; -.
DR   PhylomeDB; Q9Z2Q7; -.
DR   NextBio; 611688; -.
DR   ArrayExpress; Q9Z2Q7; -.
DR   Genevestigator; Q9Z2Q7; -.
DR   GermOnline; ENSRNOG00000003849; Rattus norvegicus.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031902; C:late endosome membrane; IDA:RGD.
DR   GO; GO:0005765; C:lysosomal membrane; IDA:RGD.
DR   GO; GO:0031201; C:SNARE complex; IDA:UniProtKB.
DR   GO; GO:0008333; P:endosome to lysosome transport; IDA:RGD.
DR   GO; GO:0006906; P:vesicle fusion; IDA:RGD.
DR   InterPro; IPR015640; Syntax_8.
DR   InterPro; IPR000727; T_SNARE_dom.
DR   PANTHER; PTHR12380:SF6; Syntax_8; 1.
DR   Pfam; PF05739; SNARE; 1.
DR   SMART; SM00397; t_SNARE; 1.
DR   PROSITE; PS00914; SYNTAXIN; FALSE_NEG.
DR   PROSITE; PS50192; T_SNARE; 1.
DR   HOGENOMDNA; RAT10.PE1010; -.
KW   ENSRNOG00000003849820036002503210000011;
KW   LOC366818; LOC366820; Stx8; STX8_RAT; AF033109;
KW   3D-structure; Coiled coil; Complete proteome; Membrane;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport;
KW   Ubl conjugation.
SQ   SEQUENCE   236 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAPDPWFSTY DSTCQIAQEI AEKIQERNQC ERRGEKTPKL TLTIRTLLKN LKVKIDLLKD
     LLLRAVSTRQ ITQLEGDRRQ NLLDDLVTRE RLLLASFKNE GSEPDLIRSS LMSEEAKRGT
     PNPWLCEEPE ETRGLGFDEI RQQQQKIIQE QDAGLDALSS IISRQKQMGQ EIGNELDEQN
     EIIDDLANLV ENTDEKLRTE ARRVTLVDRK SASCGMIMVI LLLLVAIVVV AVWPTN
//

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