(data stored in ACNUC14238 zone)

HOGENOM: RAT10_PE1011

ID   RAT10_PE1011                         STANDARD;      PRT;   604 AA.
AC   RAT10_PE1011; Q924Z9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Netrin-1;Flags: Precursor; (RAT10.PE1011).
GN   Name=Ntn1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE1011.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:NET1_RAT
CC   -!- FUNCTION: Netrins control guidance of CNS commissural axons and
CC       peripheral motor axons. Its association with either DCC or some
CC       UNC5 receptors will lead to axon attraction or repulsion,
CC       respectively. It also serve as a survival factor via its
CC       association with its receptors which prevent the initiation of
CC       apoptosis. Involved in colorectal tumorigenesis by regulating
CC       apoptosis (By similarity).
CC   -!- SUBUNIT: Binds to its receptors; DCC, UNC5A, UNC5B, UNC5C and
CC       probably UNC5D (By similarity).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix (By similarity).
CC   -!- SIMILARITY: Contains 3 laminin EGF-like domains.
CC   -!- SIMILARITY: Contains 1 laminin N-terminal domain.
CC   -!- SIMILARITY: Contains 1 NTR domain.
CC   -!- GENE_FAMILY: HOG000286017 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000003947;ENSRNOT00000005255;ENSRNOP00000005255.
DR   EMBL; AY028417; - ;
DR   EMBL; Y11353; - ;
DR   UniProtKB/Swiss-Prot; Q924Z9; -.
DR   EMBL; AY028417; AAK17014.1; -; mRNA.
DR   IPI; IPI00205229; -.
DR   RefSeq; NP_446183.1; NM_053731.1.
DR   UniGene; Rn.41052; -.
DR   HSSP; P02468; 1TLE.
DR   ProteinModelPortal; Q924Z9; -.
DR   STRING; Q924Z9; -.
DR   PRIDE; Q924Z9; -.
DR   GeneID; 114523; -.
DR   KEGG; rno:114523; -.
DR   CTD; 9423; -.
DR   RGD; 619809; Ntn1.
DR   GeneTree; ENSGT00600000084367; -.
DR   InParanoid; Q924Z9; -.
DR   OrthoDB; EOG4H19V9; -.
DR   Reactome; REACT_22291; Phosphorylation of PLCgamma by Netrin-1.
DR   Reactome; REACT_92778; Axon guidance.
DR   NextBio; 618675; -.
DR   ArrayExpress; Q924Z9; -.
DR   Genevestigator; Q924Z9; -.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0007411; P:axon guidance; NAS:RGD.
DR   InterPro; IPR013032; EGF-like_reg_CS.
DR   InterPro; IPR002049; EGF_laminin.
DR   InterPro; IPR008211; Laminin_N.
DR   InterPro; IPR001134; Netrin_domain.
DR   InterPro; IPR018933; Netrin_module_non-TIMP.
DR   InterPro; IPR008993; TIMP-like_OB-fold.
DR   Pfam; PF00053; Laminin_EGF; 3.
DR   Pfam; PF00055; Laminin_N; 1.
DR   Pfam; PF01759; NTR; 1.
DR   SMART; SM00643; C345C; 1.
DR   SMART; SM00180; EGF_Lam; 3.
DR   SMART; SM00136; LamNT; 1.
DR   SUPFAM; SSF50242; TIMP_like; 1.
DR   PROSITE; PS00022; EGF_1; 2.
DR   PROSITE; PS01186; EGF_2; FALSE_NEG.
DR   PROSITE; PS01248; EGF_LAM_1; 3.
DR   PROSITE; PS50027; EGF_LAM_2; 3.
DR   PROSITE; PS51117; LAMININ_NTER; 1.
DR   PROSITE; PS50189; NTR; 1.
DR   HOGENOMDNA; RAT10.PE1011; -.
KW   ENSRNOG00000003947820036002503210000011;
KW   Ntn1; NET1_RAT; P97556_RAT; AY028417; Y11353;
KW   Apoptosis; Complete proteome; Disulfide bond; Extracellular matrix;
KW   Glycoprotein; Laminin EGF-like domain; Reference proteome; Repeat;
KW   Secreted; Signal.
SQ   SEQUENCE   604 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MMRAVWEALA ALAAVACLVG AVRGGPGLSM FAGQAAQPDP CSDENGHPRR CIPDFVNAAF
     GKDVRVSSTC GRPPARYCVV SERGEERLRS CHLCNSSDPK KAHPPAFLTD LNNPHNLTCW
     QSENYLQFPH NVTLTLSLGK KFEVTYVSLQ FCSPRPESMA IYKSMDYGRT WVPFQFYSTQ
     CRKMYNRPHR APITKQNEQE AVCTDSHTDM RPLSGGLIAF STLDGRPSAH DFDNSPVLQD
     WVTATDIRVA FSRLHTFGDE NEDDSELARD SYYYAVSDLQ VGGRCKCNGH AARCVRDRDD
     SLVCDCRHNT AGPECDRCKP FHYDRPWQRA TAREANECVA CNCNLHARRC RFNMELYKLS
     GRKSGGVCLN CRHNTAGRHC HYCKEGFYRD MGKPITHRKA CKACDCHPVG AAGKTCNQTT
     GQCPCKDGVT GITCNRCAKG YQQSRSPIAP CIKIPVAPPT TAASSMEEPE DCDSYCKASK
     GKLKMNMKKY CRKDYAVQIH ILKADKAGDW WKFTVNIISV YKQGTSRIRR GDQSLWIRSR
     DIACKCPKIK PLKKYLLLGN AEDSPDQSGI VADKSSLVIQ WRDTWARRLR KFQQREKKGK
     CKKA
//

If you have problems or comments...

PBIL Back to PBIL home page