(data stored in ACNUC10083 zone)

HOGENOM: RAT10_PE307

ID   RAT10_PE307                          STANDARD;      PRT;   803 AA.
AC   RAT10_PE307; P51799;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=H(+)/Cl(-) exchange transporter 7;AltName: Full=Chloride
DE   channel protein 7; Short=ClC-7; (RAT10.PE307).
GN   Name=Clcn7;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE307.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCN7_RAT
CC   -!- FUNCTION: Mediates the exchange of chloride ions against protons.
CC       Functions as antiporter and contributes to the acidification of
CC       the lysosome lumen.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane; Multi-pass membrane
CC       protein.
CC   -!- TISSUE SPECIFICITY: Brain, testis, muscle and kidney.
CC   -!- MISCELLANEOUS: The CLC channel family contains both chloride
CC       channels and proton-coupled anion transporters that exchange
CC       chloride or another anion for protons. The presence of conserved
CC       gating glutamate residues is typical for family members that
CC       function as antiporters (By similarity).
CC   -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC       ClC-7/CLCN7 subfamily.
CC   -!- SIMILARITY: Contains 2 CBS domains.
CC   -!- GENE_FAMILY: HOG000231081 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000016976;ENSRNOT00000023615;ENSRNOP00000023615.
DR   EMBL; Z67744; - ;
DR   UniProtKB/Swiss-Prot; P51799; -.
DR   EMBL; Z67744; CAA91557.1; -; mRNA.
DR   IPI; IPI00205428; -.
DR   PIR; S68426; S68426.
DR   RefSeq; NP_113756.1; NM_031568.1.
DR   UniGene; Rn.10338; -.
DR   ProteinModelPortal; P51799; -.
DR   STRING; P51799; -.
DR   Ensembl; ENSRNOT00000023615; ENSRNOP00000023615; ENSRNOG00000016976.
DR   GeneID; 29233; -.
DR   KEGG; rno:29233; -.
DR   UCSC; NM_031568; rat.
DR   CTD; 1186; -.
DR   RGD; 61836; Clcn7.
DR   eggNOG; roNOG07216; -.
DR   GeneTree; ENSGT00550000074179; -.
DR   InParanoid; P51799; -.
DR   OMA; PYTVPQE; -.
DR   OrthoDB; EOG41C6VS; -.
DR   PhylomeDB; P51799; -.
DR   NextBio; 608486; -.
DR   ArrayExpress; P51799; -.
DR   Genevestigator; P51799; -.
DR   GermOnline; ENSRNOG00000016976; Rattus norvegicus.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR   GO; GO:0009268; P:response to pH; IDA:RGD.
DR   InterPro; IPR014743; Cl-channel_core.
DR   InterPro; IPR001807; Cl-channel_volt-gated.
DR   InterPro; IPR002249; Cl_channel-7.
DR   InterPro; IPR000644; Cysta_beta_synth_core.
DR   Gene3D; G3DSA:1.10.3080.10; Cl-channel_core; 2.
DR   PANTHER; PTHR11689; Cl-channel_volt; 1.
DR   Pfam; PF00571; CBS; 2.
DR   Pfam; PF00654; Voltage_CLC; 1.
DR   PRINTS; PR00762; CLCHANNEL.
DR   PRINTS; PR01118; CLCHANNEL7.
DR   SMART; SM00116; CBS; 2.
DR   SUPFAM; SSF81340; Cl-channel_core; 1.
DR   PROSITE; PS51371; CBS; 2.
DR   HOGENOMDNA; RAT10.PE307; -.
KW   ENSRNOG00000016976820036002503210000011;
KW   Clcn7; CLCN7_RAT; Z67744;
KW   Antiport; ATP-binding; CBS domain; Chloride; Complete proteome;
KW   Ion transport; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Repeat; Transmembrane; Transmembrane helix;
KW   Transport.
SQ   SEQUENCE   803 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MANVSKKVSW SGRDRDDEEG APLLRRTGQP DEETPLLNGA GPGARQSHSA LFRIGQMNNV
     ELDDELLDPE VDPPHTFPKE IPHNEKLLSL KYESLDYDNS ENQLFLEEER RINHTAFRTV
     EIKRWVICAL IGILTGLVAC FIDIVVENLA GLKYRVIKDN IDKFTEKGGL SFSLLLWATL
     NSAFVLVGSV IVAFIEPVAA GSGIPQIKCF LNGVKIPHVV RLKTLVIKVS GVILSVVGGL
     AVGKEGPMIH SGSVIAAGIS QGRSTSLKRD FKIFEYFRRD TEKRDFVSAG AAAGVSAAFG
     APVGGVLFSL EEGASFWNQF LTWRIFFASM ISTFTLNFVL SIYHGNMWDL SSPGLINFGR
     FDSEKMAYTI HEIPVFIAMG VVGGILGAVF NALNYWLTMF RIRYIHRPCL QVIEAMLVAA
     VTATVAFVLI YSSRDCQPLQ GSSMSYPLQL FCADGEYNSM AAAFFNTPEK SVVSLFHDPP
     GSYNPMTLGL FTLVYFFLAC WTYGLTVSAG VFIPSLLIGA AWGRLFGISM SYLTGAAIWA
     DPGKYALMGA AAQLGGIVRM TLSLTVIMME ATSNVTYGFP IMLVLMTAKI VGDVFIEGLY
     DMHIQLQSVP FLHWEAPVTS HSLTAREVMS TPVTCLRRRE KVGIIVDVLS DTASNHNGFP
     VVEDVGDTQP ARLQGLILRS QLIVLLKHKV FVERSNMGLV QRRLRLKDFR DAYPRFPPIQ
     SIHVSQDERE CTMDLSEFMN PSPYTVPQEA SLPRVFKLFR ALGLRHLVVV DNHNQVVGLV
     TRKDLARYRL GKGGLEELSL AQT
//

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