(data stored in ACNUC13767 zone)

HOGENOM: RAT10_PE563

ID   RAT10_PE563                          STANDARD;      PRT;   680 AA.
AC   RAT10_PE563; Q4KMC4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Glucosamine--fructose-6-phosphate aminotransferase
DE   (RAT10.PE563) [isomerizing] 2; EC=2.6.1 16;AltName:
DE   Full=D-fructose-6-phosphate amidotransferase 2;AltName:
DE   Full=Glutamine:fructose 6 phosphate amidotransferase 2; Short=GFAT 2;
DE   Short=GFAT2;AltName: Full=Hexosephosphate aminotransferase 2; .
GN   Name=Gfpt2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE563.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:GFPT2_RAT
CC   -!- FUNCTION: Controls the flux of glucose into the hexosamine
CC       pathway. Most likely involved in regulating the availability of
CC       precursors for N- and O-linked glycosylation of proteins.
CC   -!- CATALYTIC ACTIVITY: L-glutamine + D-fructose 6-phosphate = L-
CC       glutamate + D-glucosamine 6-phosphate.
CC   -!- PATHWAY: Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-
CC       glucosamine biosynthesis; alpha-D-glucosamine 6-phosphate from D-
CC       fructose 6-phosphate: step 1/1.
CC   -!- SIMILARITY: Contains 1 glutamine amidotransferase type-2 domain.
CC   -!- SIMILARITY: Contains 2 SIS domains.
CC   -!- GENE_FAMILY: HOG000258898 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000002810;ENSRNOT00000003770;ENSRNOP00000003770.
DR   EMBL; BC098630; - ;
DR   EMBL; BN000324; - ;
DR   UniProtKB/Swiss-Prot; Q4KMC4; -.
DR   EMBL; BC098630; AAH98630.1; -; mRNA.
DR   IPI; IPI00421766; -.
DR   RefSeq; NP_001002819.2; NM_001002819.2.
DR   UniGene; Rn.16089; -.
DR   ProteinModelPortal; Q4KMC4; -.
DR   SMR; Q4KMC4; 322-670.
DR   STRING; Q4KMC4; -.
DR   MEROPS; C44.972; -.
DR   PRIDE; Q4KMC4; -.
DR   GeneID; 360518; -.
DR   KEGG; rno:360518; -.
DR   CTD; 9945; -.
DR   RGD; 1303097; Gfpt2.
DR   eggNOG; roNOG04892; -.
DR   InParanoid; Q4KMC4; -.
DR   OrthoDB; EOG4DV5KT; -.
DR   PhylomeDB; Q4KMC4; -.
DR   NextBio; 673062; -.
DR   ArrayExpress; Q4KMC4; -.
DR   Genevestigator; Q4KMC4; -.
DR   GermOnline; ENSRNOG00000002810; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0004360; F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity; IEA:EC.
DR   GO; GO:0005529; F:sugar binding; IEA:InterPro.
DR   GO; GO:0016051; P:carbohydrate biosynthetic process; IEA:InterPro.
DR   GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW.
DR   InterPro; IPR000583; GATase_2.
DR   InterPro; IPR017932; GATase_II.
DR   InterPro; IPR005855; GlmS_trans.
DR   InterPro; IPR001347; SIS.
DR   Pfam; PF00310; GATase_2; 2.
DR   Pfam; PF01380; SIS; 2.
DR   TIGRFAMs; TIGR01135; GlmS; 1.
DR   PROSITE; PS51278; GATASE_TYPE_2; 1.
DR   PROSITE; PS51464; SIS; 2.
DR   HOGENOMDNA; RAT10.PE563; -.
KW   ENSRNOG00000002810820036002503210000011;
KW   Gfpt2; GFPT2_RAT; Q6IE69_RAT; BC098630; BN000324;
KW   Aminotransferase; Complete proteome; Glutamine amidotransferase;
KW   Phosphoprotein; Reference proteome; Repeat; Transferase.
SQ   SEQUENCE   680 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     AGIFAYMNYR VPKTRKEIFE TLIRGLQRLE YRGYDSAGVA IDGNNHEVKE RHIHLVKKKG
     KVKALDEELY KQDSMDLKVE FETHFGIAHT RWATHGVPNV VNSHPQRSDK DNEFVVIHNG
     IITNYKDLRK FLESKGYEFE SETDTETIAK LIKYVFDNRE TEDITFSTLV ERVIQQLEGA
     FALVFKSIHY PGEAVATRRG SPLLIGVRSK YKLSTEQIPV LYRTCTIENV KNICKTRLKR
     LDSSTCLHAV GDKAVEFFFA SDASAIIEHT NRVIFLEDDD IAAVADGKLS IHRVKRSASD
     DPSRAIQTLQ MELQQIMKGN FSAFMQKEIF EQPESVFNTM RGRVNFETNT VLLGGLKDHL
     KEIRRCRRLI VIGCGTSYHA AVATRQVLEE LTELPVMVEL ASDFLDRNTP VFRDDVCFFI
     SQSGETADTL LALRYCKDRG ALTVGTNTVG SSISRETDCG VHINAGPEIG VASTKAYTSQ
     FISLVMFGLM MSEDRISLQT RRQEIIRGLR SLPELIKEVL SLDEKIHDLA LELYTQRSLL
     VMGRGYNYAT CLEGALKIKE ITYMHSEGIL AGELKHGPLA LVDKQMPVIM VIMKDPCFAK
     CQNALQQVTA RQGRPIILCS KDDTESSKFA YKTIELPHTV DCLQGILSVI PLQLLSFHLA
     VLRGYDVDFP RNLAKSVTVE
//

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