(data stored in ACNUC8465 zone)

HOGENOM: RAT10_PE966

ID   RAT10_PE966                          STANDARD;      PRT;   273 AA.
AC   RAT10_PE966; Q4KSH6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   SubName: Full=Dual specificity mitogen-activated protein kinase kinase 4;
DE   (RAT10.PE966).
GN   Name=Map2k4;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT10.PE966.
CC       Rattus norvegicus chromosome 10 RGSC3.4  sequence 1..110718848
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:Q4KSH6_RAT
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000003834;ENSRNOT00000005293;ENSRNOP00000005293.
DR   EMBL; AY880882; - ;
DR   UniProtKB/Swiss-Prot; Q4KSH6; -.
DR   EMBL; AY880882; AAX61181.1; -; mRNA.
DR   IPI; IPI00369884; -.
DR   RefSeq; NP_001025194.1; NM_001030023.1.
DR   UniGene; Rn.198875; -.
DR   ProteinModelPortal; Q4KSH6; -.
DR   SMR; Q4KSH6; 93-386.
DR   MINT; MINT-5055087; -.
DR   STRING; Q4KSH6; -.
DR   PhosphoSite; Q4KSH6; -.
DR   PRIDE; Q4KSH6; -.
DR   GeneID; 287398; -.
DR   KEGG; rno:287398; -.
DR   CTD; 6416; -.
DR   RGD; 1307040; Map2k4.
DR   eggNOG; maNOG16269; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   InParanoid; Q4KSH6; -.
DR   OrthoDB; EOG479F76; -.
DR   PhylomeDB; Q4KSH6; -.
DR   NextBio; 626018; -.
DR   ArrayExpress; Q4KSH6; -.
DR   Genevestigator; Q4KSH6; -.
DR   GO; GO:0033267; C:axon part; IDA:RGD.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0032839; C:dendrite cytoplasm; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0043204; C:perikaryon; IDA:RGD.
DR   GO; GO:0005524; F:ATP binding; IDA:RGD.
DR   GO; GO:0008545; F:JUN kinase kinase activity; IDA:RGD.
DR   GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0007257; P:activation of JUN kinase activity; IDA:RGD.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IMP:RGD.
DR   GO; GO:0043525; P:positive regulation of neuron apoptosis; IMP:RGD.
DR   GO; GO:0001934; P:positive regulation of protein phosphorylation; IDA:RGD.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RAT10.PE966; -.
KW   ENSRNOG00000003834820036002503210000011;
KW   Map2k4; Q4KSH6_RAT; AY880882;
KW   ATP-binding; Kinase; Nucleotide-binding.
SQ   SEQUENCE   273 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     IILFQRIRST VDEKEQKQLL MDLDVVMRSS DCPYIVQFYG ALFREGDCWI CMELMSTSFD
     KFYKYVYSVL DDVIPEEILG KITLATVKAL NHLKENLKII HRDIKPSNIL LDRSGNIKLC
     DFGISGQLVD SIAKTRDAGC RPYMAPERID PSASRQGYDV RSDVWSLGIT LYELATGRFP
     YPKWNSVFDQ LTQVVKGDPP QLSNSEEREF SPSFINFVNL CLTKDESKRP KYKELLKHPF
     ILMYEERTVE VACYVCKILD QMPATPSSPM YVD
//

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