(data stored in ACNUC8465 zone)

HOGENOM: RAT12_PE30

ID   RAT12_PE30                           STANDARD;      PRT;   452 AA.
AC   RAT12_PE30; Q4KSH7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Dual specificity mitogen-activated protein kinase kinase 7;
DE   Short=MAP kinase kinase 7; Short=MAPKK 7; EC=2.7.12 2;AltName:
DE   Full=JNK-activating kinase 2;AltName: Full=MAPK/ERK kinase 7; Short=MEK
DE   7;AltName: Full=c-Jun N-terminal kinase kinase 2; Short=JNK kinase 2;
DE   Short=JNKK 2; (RAT12.PE30).
GN   Name=Map2k7;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT12.PE30.
CC       Rattus norvegicus chromosome 12 RGSC3.4  sequence 1..46782294
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MP2K7_RAT
CC   -!- FUNCTION: Stress activated, dual specificity kinase that activates
CC       the JUN kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3.
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC   -!- COFACTOR: Magnesium.
CC   -!- ENZYME REGULATION: Activated by phosphorylation by specific MAP
CC       kinase kinase kinases such as MAP3K1/MEKK1, MAP3K3/MEKK3,
CC       MAP3K11/MLK3 and MAP3K12/DLK (By similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus. Cytoplasm (By similarity).
CC   -!- PTM: Phosphorylated on Ser/Thr residues (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
CC       protein kinase family. MAP kinase kinase subfamily.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000234206 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000001047;ENSRNOT00000061821;ENSRNOP00000058535.
DR   EMBL; AY879265; - ;
DR   UniProtKB/Swiss-Prot; Q4KSH7; -.
DR   EMBL; AY879265; AAX61178.1; -; mRNA.
DR   IPI; IPI00779757; -.
DR   RefSeq; NP_001020596.1; NM_001025425.1.
DR   UniGene; Rn.162081; -.
DR   HSSP; P36507; 1S9I.
DR   ProteinModelPortal; Q4KSH7; -.
DR   SMR; Q4KSH7; 103-402.
DR   STRING; Q4KSH7; -.
DR   GeneID; 363855; -.
DR   KEGG; rno:363855; -.
DR   UCSC; NM_001025425; rat.
DR   CTD; 5609; -.
DR   RGD; 1560043; Map2k7.
DR   eggNOG; roNOG15478; -.
DR   GeneTree; ENSGT00570000078767; -.
DR   PhylomeDB; Q4KSH7; -.
DR   NextBio; 684348; -.
DR   ArrayExpress; Q4KSH7; -.
DR   Genevestigator; Q4KSH7; -.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0005524; F:ATP binding; IDA:RGD.
DR   GO; GO:0008545; F:JUN kinase kinase activity; IDA:RGD.
DR   GO; GO:0000287; F:magnesium ion binding; IDA:UniProtKB.
DR   GO; GO:0031435; F:mitogen-activated protein kinase kinase kinase binding; IPI:RGD.
DR   GO; GO:0008022; F:protein C-terminus binding; IPI:RGD.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0007257; P:activation of JUN kinase activity; IDA:RGD.
DR   GO; GO:0043525; P:positive regulation of neuron apoptosis; IMP:RGD.
DR   GO; GO:0051403; P:stress-activated MAPK cascade; IDA:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RAT12.PE30; -.
KW   ENSRNOG00000001047820036002503210000011;
KW   Map2k7; MP2K7_RAT; AY879265;
KW   Acetylation; ATP-binding; Coiled coil; Complete proteome; Cytoplasm;
KW   Kinase; Magnesium; Metal-binding; Nucleotide-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Serine/threonine-protein kinase;
KW   Transferase; Tyrosine-protein kinase.
SQ   SEQUENCE   452 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PTLQLPLAND GGSRSPSSES
     SPQHPTPPSR PRHMLGLPST LFTPRSMESI EIDQKLQEIM KQTGYLTIGG QRYQAEINDL
     ENLGEMGSGT CGQVWKMRFR KTGHIIAVKQ MRRSGNKEEN KRILMDLDVV LKSHDCPYIV
     QCFGTFITNT DVFIAMELMG TCAEKLKKRM QGPIPERILG KMTVAIVKAL YYLKEKHGVI
     HRDVKPSNIL LDERGQIKLC DFGISGRLVD SKAKTRSAGC AAYMAPERID PPDPTKPDYD
     IRADVWSLGI SLVELATGQF PYKNCKTDFE VLTKVLQEEP PLLPGHMGFS GDFQSFVKDC
     LTKDHRKRPK YNKLLEHSFI KHYETLEVDV ASWFKDVMAK TESPRTSGVL SQHHLPFFSG
     SLEESPTSLP FPKSFPLSPA IPLAQAEWVL GR
//

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