(data stored in ACNUC13676 zone)

HOGENOM: RAT12_PE334

ID   RAT12_PE334                          STANDARD;      PRT;   453 AA.
AC   RAT12_PE334; Q2PWT8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AP-4 complex subunit mu-1;AltName: Full=AP-4 adapter
DE   complex mu subunit;AltName: Full=Adapter-related protein complex 4 mu-1
DE   subunit;AltName: Full=Mu subunit of AP-4;AltName: Full=Mu-adaptin-related
DE   protein 2; Short=mu-ARP2;AltName: Full=Mu4-adaptin; Short=mu4;
DE   (RAT12.PE334).
GN   Name=Ap4m1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT12.PE334.
CC       Rattus norvegicus chromosome 12 RGSC3.4  sequence 1..46782294
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AP4M1_RAT
CC   -!- FUNCTION: Subunit of novel type of clathrin- or non-clathrin-
CC       associated protein coat involved in targeting proteins from the
CC       trans-Golgi network (TGN) to the endosomal-lysosomal system (By
CC       similarity).
CC   -!- SUBUNIT: Adapter-like complex 4 (AP-4) is an heterotetramer
CC       composed of two large adaptins (epsilon-type subunit AP4E1 and
CC       beta-type subunit AP4B1), a medium adaptin (mu-type subunit AP4M1)
CC       and a small adaptin (sigma-type AP4S1). Interacts with the C-
CC       terminal domain of GRID2.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus, trans-Golgi network.
CC       Membrane, coated pit. Note=Associated with the trans-Golgi
CC       network. Found in soma and dendritic shafts of neuronal cells.
CC   -!- TISSUE SPECIFICITY: High levels in the olfactory bulb, the
CC       cerebral cortex, the granule and Purkinje cell layers of the
CC       cerebellar cortex and the CA3 region of the hippocampus. Low
CC       levels found in molecular layer of cerebellum.
CC   -!- SIMILARITY: Belongs to the adaptor complexes medium subunit
CC       family.
CC   -!- SIMILARITY: Contains 1 MHD (mu homology) domain.
CC   -!- GENE_FAMILY: HOG000173245 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000001353;ENSRNOT00000001827;ENSRNOP00000001827.
DR   EMBL; DQ298439; - ;
DR   UniProtKB/Swiss-Prot; Q2PWT8; -.
DR   EMBL; DQ298439; ABC02084.1; -; mRNA.
DR   IPI; IPI00370600; -.
DR   RefSeq; NP_001033066.1; NM_001037977.1.
DR   UniGene; Rn.154558; -.
DR   ProteinModelPortal; Q2PWT8; -.
DR   STRING; Q2PWT8; -.
DR   Ensembl; ENSRNOT00000001827; ENSRNOP00000001827; ENSRNOG00000001353.
DR   GeneID; 304344; -.
DR   KEGG; rno:304344; -.
DR   CTD; 9179; -.
DR   RGD; 1310233; Ap4m1.
DR   eggNOG; roNOG06535; -.
DR   GeneTree; ENSGT00530000062779; -.
DR   InParanoid; Q2PWT8; -.
DR   OMA; CGNANPH; -.
DR   OrthoDB; EOG4RJG1M; -.
DR   PhylomeDB; Q2PWT8; -.
DR   NextBio; 652924; -.
DR   Genevestigator; Q2PWT8; -.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0005905; C:coated pit; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR   InterPro; IPR022775; AP_mu_sigma_su.
DR   InterPro; IPR001392; Clathrin_mu.
DR   InterPro; IPR008968; Clathrin_mu_C.
DR   InterPro; IPR018240; Clathrin_mu_CS.
DR   InterPro; IPR011012; Longin-like.
DR   Pfam; PF00928; Adap_comp_sub; 1.
DR   Pfam; PF01217; Clat_adaptor_s; 1.
DR   PIRSF; PIRSF005992; Clathrin_mu; 1.
DR   PRINTS; PR00314; CLATHRINADPT.
DR   SUPFAM; SSF49447; AP50; 1.
DR   SUPFAM; SSF64356; Longin_like; 1.
DR   PROSITE; PS00990; CLAT_ADAPTOR_M_1; FALSE_NEG.
DR   PROSITE; PS00991; CLAT_ADAPTOR_M_2; 1.
DR   PROSITE; PS51072; MHD; 1.
DR   HOGENOMDNA; RAT12.PE334; -.
KW   ENSRNOG00000001353820036002503210000011;
KW   Ap4m1; AP4M1_RAT; DQ298439;
KW   Coated pit; Complete proteome; Golgi apparatus; Membrane;
KW   Phosphoprotein; Protein transport; Reference proteome; Transport.
SQ   SEQUENCE   453 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MISQFFILSS KGDPLIYKDF RGDSGGRDVA ELFYRKLTGL PGGESPVVMY HDDRHFIHIR
     HSGLYLVATT SENVSPFSLL ELLSRLATLL GDYCGSLNEG TISRNVALVY ELLDEVLDYG
     YVQTTSTDML RNFIQTEAAV SKPFSLFDLS SVGLFGAETQ QNRVAPSSAA SRPVLSSRSD
     QSQKNEVFLD VVERLSVLIA SNGSLLKVDV QGEIRLKSFL PSSSEICIGL TEEFCVGKSE
     LRGYGPGIRV DEVSFHSSVN LDEFESHRIL HLQPPQGELT VMRYQLSDDL PSPLPFRLFP
     SVQWDQGSGR LQVYLKLRCD LPPKSQALNI HLHLPLPRGV VSLSQELSSP DQKAELGEGA
     LHWDLPRVQG GSQLSGLFQM DVPGLQGPPS RGPSPSAPPL GLGPASLSFE LPRHTCSGLQ
     VRFLRLSFSA CGNANPHKWV RHLSHSNAYV IRI
//

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