(data stored in ACNUC17492 zone)

HOGENOM: RAT13_PE356

ID   RAT13_PE356                          STANDARD;      PRT;   211 AA.
AC   RAT13_PE356; Q9JHX0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 2; Short=RGS2;
DE   (RAT13.PE356).
GN   Name=Rgs2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT13.PE356.
CC       Rattus norvegicus chromosome 13 RGSC3.4  sequence 1..111154910
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS2_RAT
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. May play a role in leukemogenesis.
CC       Binds EIF2B5 and blocks its activity, thereby inhibiting the
CC       translation of mRNA into protein (By similarity).
CC   -!- SUBUNIT: Interacts with EIF2B5 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane (By similarity). Cytoplasm (By
CC       similarity). Nucleus, nucleolus (By similarity).
CC   -!- PTM: Phosphorylated by protein kinase C (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000003687;ENSRNOT00000005156;ENSRNOP00000005156.
DR   EMBL; AF279918; - ;
DR   EMBL; AF321837; - ;
DR   EMBL; AJ318489; - ;
DR   EMBL; AY043246; - ;
DR   EMBL; BC061969; - ;
DR   UniProtKB/Swiss-Prot; Q9JHX0; -.
DR   EMBL; AF279918; AAF85981.1; -; mRNA.
DR   EMBL; AF321837; AAK09375.1; -; mRNA.
DR   EMBL; AY043246; AAK85309.1; -; mRNA.
DR   EMBL; BC061969; AAH61969.1; -; mRNA.
DR   EMBL; AJ318489; CAC44900.1; -; mRNA.
DR   IPI; IPI00200023; -.
DR   RefSeq; NP_445905.1; NM_053453.2.
DR   UniGene; Rn.1892; -.
DR   ProteinModelPortal; Q9JHX0; -.
DR   SMR; Q9JHX0; 70-203.
DR   STRING; Q9JHX0; -.
DR   Ensembl; ENSRNOT00000005156; ENSRNOP00000005156; ENSRNOG00000003687.
DR   GeneID; 84583; -.
DR   KEGG; rno:84583; -.
DR   UCSC; NM_053453; rat.
DR   CTD; 5997; -.
DR   RGD; 621665; Rgs2.
DR   eggNOG; roNOG12367; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; Q9JHX0; -.
DR   OMA; AKKIYTD; -.
DR   OrthoDB; EOG4ZGPD8; -.
DR   PhylomeDB; Q9JHX0; -.
DR   NextBio; 617163; -.
DR   ArrayExpress; Q9JHX0; -.
DR   Genevestigator; Q9JHX0; -.
DR   GermOnline; ENSRNOG00000003687; Rattus norvegicus.
DR   GO; GO:0009898; C:internal side of plasma membrane; IDA:BHF-UCL.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0045744; P:negative regulation of G-protein coupled receptor protein signaling pathway; IEP:RGD.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; RAT13.PE356; -.
KW   ENSRNOG00000003687820036002503210000011;
KW   Rgs2; RGS2_RAT; AF279918; AF321837; AJ318489; AY043246; BC061969;
KW   Cell cycle; Cell membrane; Complete proteome; Cytoplasm; Membrane;
KW   Nucleus; Phosphoprotein; Reference proteome;
KW   Signal transduction inhibitor; Translation regulation.
SQ   SEQUENCE   211 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MQSAMFLAVQ HDCVPMDKSA GNGPKVEEKR EKMKRTLLKD WKTRLSYFLQ NSSTPGKPKT
     GKKSKQQTFI KPSPEEALLW AEAFDELLAS KYGLAAFRAF LKSEFCEENI EFWLACEDFK
     KTKSPQKLSS KARKIYTDFI EKEAPKEINI DFQTKTLIAQ NIQEATSGCF TTAQKRVYSL
     MENNSYPRFL ESEFYQDLCK KPQITTEPHA T
//

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