(data stored in ACNUC17492 zone)

HOGENOM: RAT13_PE360

ID   RAT13_PE360                          STANDARD;      PRT;   235 AA.
AC   RAT13_PE360; Q4L0E8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 18; Short=RGS18;
DE   (RAT13.PE360).
GN   Name=Rgs18;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT13.PE360.
CC       Rattus norvegicus chromosome 13 RGSC3.4  sequence 1..111154910
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS18_RAT
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-
CC       2, G(i) alpha-3 and G(q) alpha (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000003959;ENSRNOT00000005324;ENSRNOP00000005324.
DR   EMBL; AY651776; - ;
DR   UniProtKB/Swiss-Prot; Q4L0E8; -.
DR   EMBL; AY651776; AAV85503.1; -; mRNA.
DR   IPI; IPI00203674; -.
DR   RefSeq; NP_001040549.1; NM_001047084.1.
DR   UniGene; Rn.202353; -.
DR   HSSP; P49799; 1AGR.
DR   ProteinModelPortal; Q4L0E8; -.
DR   SMR; Q4L0E8; 75-206.
DR   STRING; Q4L0E8; -.
DR   PRIDE; Q4L0E8; -.
DR   GeneID; 289076; -.
DR   KEGG; rno:289076; -.
DR   CTD; 64407; -.
DR   RGD; 1306522; Rgs18.
DR   eggNOG; roNOG16386; -.
DR   GeneTree; ENSGT00600000084388; -.
DR   InParanoid; Q4L0E8; -.
DR   OrthoDB; EOG42BX9H; -.
DR   NextBio; 629173; -.
DR   Genevestigator; Q4L0E8; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; RAT13.PE360; -.
KW   ENSRNOG00000003959820036002503210000011;
KW   Rgs18; RGS18_RAT; AY651776;
KW   Complete proteome; Cytoplasm; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   235 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MEMSLVFFSH LNMCESKEKT FFKLMHGSGK EETNIEAKIR AKEKRNRLSL LLQRPDFHGE
     THTSRSALLA KETRVSSEEA LKWAESFDKL LSHRDGVDAF TRFLKTEFSE ENIEFWVACE
     DFKKCTEPQQ LILKAKSIYE KFIKNDAPKE VNLDFHTKEV ITKSIAQPTL HSFDAAQSRV
     CQLMEHDSYK RFLKSEIYLH LIEGRPQRPT NLRRRSRSFT YNEFQDVKSD VAIWL
//

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