(data stored in ACNUC17492 zone)

HOGENOM: RAT13_PE421

ID   RAT13_PE421                          STANDARD;      PRT;   180 AA.
AC   RAT13_PE421; P49804;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 8; Short=RGS8;
DE   (RAT13.PE421).
GN   Name=Rgs8;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT13.PE421.
CC       Rattus norvegicus chromosome 13 RGSC3.4  sequence 1..111154910
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS8_RAT
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Preferentially binds to G(o)-alpha
CC       and G(i)-alpha-3.
CC   -!- TISSUE SPECIFICITY: Expressed at high levels in brain. Very little
CC       expression detected in other tissues.
CC   -!- DEVELOPMENTAL STAGE: Detected in 13-day old embryos. Expression
CC       increases gradually in later embryos and markedly in neonates to
CC       adults.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000002369;ENSRNOT00000003239;ENSRNOP00000003239.
DR   EMBL; AB006013; - ;
DR   EMBL; BC089064; - ;
DR   EMBL; U32432; - ;
DR   UniProtKB/Swiss-Prot; P49804; -.
DR   EMBL; AB006013; BAA23680.1; -; mRNA.
DR   EMBL; BC089064; AAH89064.1; -; mRNA.
DR   EMBL; U32432; AAC52369.1; -; mRNA.
DR   IPI; IPI00198047; -.
DR   RefSeq; NP_062217.1; NM_019344.2.
DR   UniGene; Rn.89634; -.
DR   ProteinModelPortal; P49804; -.
DR   SMR; P49804; 46-176.
DR   STRING; P49804; -.
DR   PhosphoSite; P49804; -.
DR   Ensembl; ENSRNOT00000003239; ENSRNOP00000003239; ENSRNOG00000002369.
DR   GeneID; 54297; -.
DR   KEGG; rno:54297; -.
DR   UCSC; NM_019344; rat.
DR   CTD; 85397; -.
DR   RGD; 3571; Rgs8.
DR   eggNOG; roNOG16741; -.
DR   GeneTree; ENSGT00600000084096; -.
DR   InParanoid; P49804; -.
DR   OMA; SCFDQAQ; -.
DR   OrthoDB; EOG4RV2SM; -.
DR   PhylomeDB; P49804; -.
DR   NextBio; 610928; -.
DR   ArrayExpress; P49804; -.
DR   Genevestigator; P49804; -.
DR   GermOnline; ENSRNOG00000002369; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; RAT13.PE421; -.
KW   ENSRNOG00000002369820036002503210000011;
KW   Rgs8; RGS8_RAT; AB006013; BC089064; U32432;
KW   Complete proteome; Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   180 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAALLMPRRN KGMRTRLGCL SHKSDSCSDF TAILPDKPNR ALKRLSTEEA TRWADSFDVL
     LSHKYGVAAF RAFLKTEFSE ENLEFWLACE EFKKTRSTAK LVTKAHRIFE EFVDVQAPRE
     VNIDFQTREA TRKNMQEPSL TCFDQAQGKV HSLMEKDSYP RFLRSKMYLD LLSQSQRRLS
//

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