(data stored in ACNUC17492 zone)

HOGENOM: RAT13_PE423

ID   RAT13_PE423                          STANDARD;      PRT;   199 AA.
AC   RAT13_PE423; P56700;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 16; Short=RGS16;AltName:
DE   Full=Retinal-specific RGS; Short=RGS-r;AltName: Full=Retinally abundant
DE   regulator of G-protein signaling; (RAT13.PE423).
GN   Name=Rgs16; Synonyms=Rgsr;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT13.PE423.
CC       Rattus norvegicus chromosome 13 RGSC3.4  sequence 1..111154910
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS16_RAT
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha,
CC       but not to G(s)-alpha. Plays an important role in the
CC       phototransduction cascade by regulating the lifetime and effective
CC       concentration of activated transducin alpha.
CC   -!- TISSUE SPECIFICITY: Predominantly found in the retina. Some
CC       expression has been found in the liver.
CC   -!- PTM: Either Cys-2 or Cys-12 or both are palmitoylated (By
CC       similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000027024;ENSRNOT00000032236;ENSRNOP00000029844.
DR   EMBL; AY651775; - ;
DR   UniProtKB/Swiss-Prot; P56700; -.
DR   IPI; IPI00556938; -.
DR   UniGene; Rn.202892; -.
DR   ProteinModelPortal; P56700; -.
DR   SMR; P56700; 53-180.
DR   STRING; P56700; -.
DR   PRIDE; P56700; -.
DR   RGD; 1589741; Rgs16.
DR   eggNOG; roNOG14080; -.
DR   InParanoid; P56700; -.
DR   OrthoDB; EOG4STS5S; -.
DR   Genevestigator; P56700; -.
DR   GermOnline; ENSRNOG00000027024; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005624; C:membrane fraction; IDA:RGD.
DR   GO; GO:0045121; C:membrane raft; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; RAT13.PE423; -.
KW   ENSRNOG00000027024820036002503210000011;
KW   Rgs16; RGS16_RAT; Q4L0E9_RAT; AY651775;
KW   Complete proteome; Lipoprotein; Palmitate; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   199 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCRTLATFPN TCLERAKEFK TRLGIFLHKS ELSSDTGGNG KFEWASKLSK ERSFSEDVLG
     WRESFQSLLN SKNGVAAFHA FLKTEFSEEN LEFWLACEEF KKIRSATKLA SRAHHIFDEY
     IRSEAPKEVN IDHETRELTK TNLQAATPSC FDVAQGKTRT LMEKDSYPRF LKSPAYRDLA
     AQASATSASG SSPAEPSHT
//

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