(data stored in ACNUC17492 zone)

HOGENOM: RAT13_PE651

ID   RAT13_PE651                          STANDARD;      PRT;   205 AA.
AC   RAT13_PE651; P49799;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 4; Short=RGP4; Short=RGS4;
DE   (RAT13.PE651).
GN   Name=Rgs4;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT13.PE651.
CC       Rattus norvegicus chromosome 13 RGSC3.4  sequence 1..111154910
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS4_RAT
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Activity on G(z)-alpha is inhibited
CC       by phosphorylation of the G-protein. Activity on G(z)-alpha and
CC       G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
CC   -!- PTM: Either Cys-2 or Cys-12 or both are palmitoylated (By
CC       similarity).
CC   -!- PTM: Phosphorylated by cyclic GMP-dependent protein kinase.
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000002773;ENSRNOT00000003774;ENSRNOP00000003774.
DR   EMBL; AF117211; - ;
DR   EMBL; U27767; - ;
DR   EMBL; U32327; - ;
DR   UniProtKB/Swiss-Prot; P49799; -.
DR   EMBL; U27767; AAC52440.1; -; mRNA.
DR   EMBL; AF117211; AAD12065.1; -; mRNA.
DR   EMBL; U32327; AAC52367.1; -; mRNA.
DR   IPI; IPI00231345; -.
DR   RefSeq; NP_058910.1; NM_017214.1.
DR   UniGene; Rn.11065; -.
DR   PDB; 1AGR; X-ray; 2.80 A; E/H=1-205.
DR   PDB; 1EZT; NMR; -; A=51-205.
DR   PDB; 1EZY; NMR; -; A=51-205.
DR   PDBsum; 1AGR; -.
DR   PDBsum; 1EZT; -.
DR   PDBsum; 1EZY; -.
DR   ProteinModelPortal; P49799; -.
DR   SMR; P49799; 51-179.
DR   DisProt; DP00063; -.
DR   DIP; DIP-6074N; -.
DR   IntAct; P49799; 1.
DR   STRING; P49799; -.
DR   PRIDE; P49799; -.
DR   Ensembl; ENSRNOT00000003774; ENSRNOP00000003774; ENSRNOG00000002773.
DR   GeneID; 29480; -.
DR   KEGG; rno:29480; -.
DR   UCSC; NM_017214; rat.
DR   CTD; 5999; -.
DR   RGD; 3567; Rgs4.
DR   eggNOG; roNOG16162; -.
DR   GeneTree; ENSGT00600000084388; -.
DR   InParanoid; P49799; -.
DR   OMA; DCPSLVP; -.
DR   OrthoDB; EOG4PK297; -.
DR   PhylomeDB; P49799; -.
DR   NextBio; 609328; -.
DR   ArrayExpress; P49799; -.
DR   Genevestigator; P49799; -.
DR   GermOnline; ENSRNOG00000002773; Rattus norvegicus.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0005624; C:membrane fraction; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; IDA:RGD.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR024066; Regulat_G_prot_signal_dom1.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Gene3D; G3DSA:1.10.196.10; G3DSA:1.10.196.10; 1.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SMART; SM00315; RGS; 1.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; RAT13.PE651; -.
KW   ENSRNOG00000002773820036002503210000011;
KW   Rgs4; RGS4_RAT; AF117211; U27767; U32327;
KW   3D-structure; Complete proteome; Lipoprotein; Palmitate;
KW   Phosphoprotein; Reference proteome; Signal transduction inhibitor.
SQ   SEQUENCE   205 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MCKGLAGLPA SCLRSAKDMK HRLGFLLQKS DSCEHSSSHS KKDKVVTCQR VSQEEVKKWA
     ESLENLINHE CGLAAFKAFL KSEYSEENID FWISCEEYKK IKSPSKLSPK AKKIYNEFIS
     VQATKEVNLD SCTREETSRN MLEPTITCFD EAQKKIFNLM EKDSYRRFLK SRFYLDLTNP
     SSCGAEKQKG AKSSADCTSL VPQCA
//

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