(data stored in ACNUC22857 zone)

HOGENOM: RAT14_PE861

ID   RAT14_PE861                          STANDARD;      PRT;   949 AA.
AC   RAT14_PE861; P52303;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AP-1 complex subunit beta-1;AltName: Full=Adapter-related
DE   protein complex 1 subunit beta-1;AltName: Full=Adaptor protein complex
DE   AP-1 subunit beta-1;AltName: Full=Beta-1-adaptin;AltName:
DE   Full=Beta-adaptin 1;AltName: Full=Clathrin assembly protein complex 1
DE   beta large chain;AltName: Full=Golgi adaptor HA1/AP1 adaptin beta
DE   subunit; (RAT14.PE861).
GN   Name=Ap1b1; Synonyms=Adtb1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT14.PE861.
CC       Rattus norvegicus chromosome 14 RGSC3.4  sequence 1..112194335
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AP1B1_RAT
CC   -!- FUNCTION: Subunit of clathrin-associated adaptor protein complex 1
CC       that plays a role in protein sorting in the late-Golgi/trans-Golgi
CC       network (TGN) and/or endosomes. The AP complexes mediate both the
CC       recruitment of clathrin to membranes and the recognition of
CC       sorting signals within the cytosolic tails of transmembrane cargo
CC       molecules.
CC   -!- SUBUNIT: Adaptor protein complex 1 (AP-1) is an heterotetramer
CC       composed of two large adaptins (gamma-type subunit AP1G1 and beta-
CC       type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or
CC       AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or
CC       AP1S3).
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus. Cytoplasmic vesicle,
CC       clathrin-coated vesicle membrane; Peripheral membrane protein;
CC       Cytoplasmic side. Note=Component of the coat surrounding the
CC       cytoplasmic face of coated vesicles located at the Golgi complex.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=A;
CC         IsoId=P52303-1; Sequence=Displayed;
CC       Name=B;
CC         IsoId=P52303-2; Sequence=VSP_000164;
CC   -!- PTM: The N-terminus is blocked.
CC   -!- SIMILARITY: Belongs to the adaptor complexes large subunit family.
CC   -!- CAUTION: Was originally (PubMed:2495531) thought to be part of the
CC       complex AP-2.
CC   -!- GENE_FAMILY: HOG000163270 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000008786;ENSRNOT00000057407;ENSRNOP00000054218.
DR   EMBL; M77245; - ;
DR   UniProtKB/Swiss-Prot; P52303; -.
DR   EMBL; M77245; AAA40807.1; -; mRNA.
DR   IPI; IPI00201713; -.
DR   IPI; IPI00781585; -.
DR   PIR; B32105; B32105.
DR   RefSeq; NP_058973.1; NM_017277.1.
DR   UniGene; Rn.37383; -.
DR   PDB; 1W63; X-ray; 4.00 A; B/D/F/H/J/L=1-584.
DR   PDBsum; 1W63; -.
DR   ProteinModelPortal; P52303; -.
DR   SMR; P52303; 2-583, 717-949.
DR   IntAct; P52303; 3.
DR   MINT; MINT-1344522; -.
DR   STRING; P52303; -.
DR   PhosphoSite; P52303; -.
DR   PRIDE; P52303; -.
DR   GeneID; 29663; -.
DR   KEGG; rno:29663; -.
DR   UCSC; NM_017277; rat.
DR   CTD; 162; -.
DR   RGD; 2064; Ap1b1.
DR   eggNOG; roNOG10896; -.
DR   GeneTree; ENSGT00530000063138; -.
DR   PhylomeDB; P52303; -.
DR   NextBio; 609967; -.
DR   ArrayExpress; P52303; -.
DR   Genevestigator; P52303; -.
DR   GermOnline; ENSRNOG00000008786; Rattus norvegicus.
DR   GO; GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
DR   GO; GO:0030665; C:clathrin coated vesicle membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008565; F:protein transporter activity; IEA:InterPro.
DR   GO; GO:0048268; P:clathrin coat assembly; IDA:BHF-UCL.
DR   GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   InterPro; IPR016342; AP_complex_bsu.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR012295; Beta2_adaptin/TATA-box-bd_C.
DR   InterPro; IPR009028; Calthrin/coatomer_app_sub_C.
DR   InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR   InterPro; IPR013041; Clathrin/coatomer_app_Ig-like.
DR   InterPro; IPR008152; Clathrin_a/b/g-adaptin_app_Ig.
DR   InterPro; IPR013037; Clathrin_b-adaptin_app_Ig-like.
DR   InterPro; IPR015151; Clathrin_b-adaptin_app_sub_C.
DR   Gene3D; G3DSA:1.25.10.10; ARM-like; 1.
DR   Gene3D; G3DSA:3.30.310.10; b_Adaptin_TBP_C; 1.
DR   Gene3D; G3DSA:2.60.40.1150; Clathrin_b-adaptin_app_Ig-like; 1.
DR   Pfam; PF01602; Adaptin_N; 1.
DR   Pfam; PF02883; Alpha_adaptinC2; 1.
DR   Pfam; PF09066; B2-adapt-app_C; 1.
DR   PIRSF; PIRSF002291; AP_complex_beta; 1.
DR   SMART; SM00809; Alpha_adaptinC2; 1.
DR   SUPFAM; SSF55711; AP2_adap_app; 1.
DR   SUPFAM; SSF48371; ARM-type_fold; 1.
DR   SUPFAM; SSF49348; Clath_adapt; 1.
DR   HOGENOMDNA; RAT14.PE861; -.
KW   ENSRNOG00000008786820036002503210000011;
KW   Ap1b1; AP1B1_RAT; M77245;
KW   3D-structure; Acetylation; Alternative splicing; Complete proteome;
KW   Cytoplasmic vesicle; Direct protein sequencing; Endocytosis;
KW   Golgi apparatus; Membrane; Phosphoprotein; Protein transport;
KW   Reference proteome; Transport.
SQ   SEQUENCE   949 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MTDSKYFTTT KKGEIFELKA ELNSDKKEKK KEAVKKVIAS MTVGKDVSAL FPDVVNCMQT
     DNLELKKLVY LYLMNYAKSQ PDMAIMAVNT FVKDCEDPNP LIRALAVRTM GCIRVDKITE
     YLCEPLRKCL KDEDPYVRKT AAVCVAKLHD INAQLVEDQG FLDTLKDLIS DSNPMVVANA
     VAALSEIAES HPSSNLLDLN PQSINKLLTA LNECTEWGQI FILDCLANYM PKDDREAQSI
     CERVTPRLSH ANSAVVLSAV KVLMKFMEML SKDLDYYATL LKKLAPPLVT LLSAEPELQY
     VALRNINLIV QKRPEILKHE MKVFFVKYND PIYVKLEKLD IMIRLASQAN IAQVLAELKE
     YATEVDVDFV RKAVRAIGRC AIKVEQSAER CVSTLLDLIQ TKVNYVVQEA IVVIKDIFRK
     YPNKYESVIA TLCENLDSLD EPEARAAMIW IVGEYAERID NADELLESFL DGFHDESTQV
     QLQLLTAIVK LFLKKPTETQ ELVQQVLSLA TQDSDNPDLR DRGYIYWRLL STDPVAAKEV
     VLAEKPLISE ETDLIEPTLL DELICYIGTL ASVYHKPPNA FVEGGRGVVH KSLPPRTASS
     ESTESPEAAP AGAPASDQPD VIPAQGDLLG DLLNLDLGPP VSGPPLAASS VQMGAVDLLG
     GGLDSLMGDE PEGIGDSNFG APPASVAAAA PARLGAPVSS GLSDLFDLTS GVGTLSGSYV
     APKAVWLPAM KAKGLEISGT FTRQVGSISM DLQLTNKALQ VMTDFAIQFN RNSFGLAPAA
     PLQVHAPLSP NQTVEISLPL NTVGSVMKME PLNNLQVAVK NNIDVFYFST LYPLHVLFVE
     DGKMDRQMFL ATWKDIPNEN EAQFQIRDCP LNTEAASSKL QSSNIFTVAK RTVEGQDMLY
     QSLKLTNGIW VLAELRIQPG NPSFTLSLKC RAPEVSQHVY QAYETILKN
//

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