(data stored in ACNUC27125 zone)

HOGENOM: RAT15_PE52

ID   RAT15_PE52                           STANDARD;      PRT;   497 AA.
AC   RAT15_PE52; P20651; Q6LDJ7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   RecName: Full=Serine/threonine-protein phosphatase 2B catalytic subunit
DE   beta isoform; EC=3.1.3 16;AltName: Full=CAM-PRP catalytic
DE   subunit;AltName: Full=Calmodulin-dependent calcineurin A subunit beta
DE   isoform; (RAT15.PE52).
GN   Name=Ppp3cb;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT15.PE52.
CC       Rattus norvegicus chromosome 15 RGSC3.4  sequence 1..109758846
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PP2BB_RAT
CC   -!- FUNCTION: Calcium-dependent, calmodulin-stimulated protein
CC       phosphatase. This subunit may have a role in the calmodulin
CC       activation of calcineurin.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- COFACTOR: Binds 1 Fe(3+) ion per subunit (By similarity).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- SUBUNIT: Composed of two components (A and B), the A component is
CC       the catalytic subunit and the B component confers calcium
CC       sensitivity.
CC   -!- SIMILARITY: Belongs to the PPP phosphatase family. PP-2B
CC       subfamily.
CC   -!- GENE_FAMILY: HOG000172699 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000007757;ENSRNOT00000010476;ENSRNOP00000010476.
DR   EMBL; D90036; - ;
DR   EMBL; M31809; - ;
DR   EMBL; M58441; - ;
DR   UniProtKB/Swiss-Prot; P20651; Q6LDJ7; -.
DR   EMBL; M31809; AAA40848.1; -; mRNA.
DR   EMBL; D90036; BAA14084.1; -; mRNA.
DR   EMBL; M58441; AAA41915.1; -; mRNA.
DR   IPI; IPI00201407; -.
DR   PIR; A33794; A33794.
DR   RefSeq; NP_058738.1; NM_017042.1.
DR   UniGene; Rn.11063; -.
DR   ProteinModelPortal; P20651; -.
DR   SMR; P20651; 24-381.
DR   DIP; DIP-66N; -.
DR   STRING; P20651; -.
DR   PhosphoSite; P20651; -.
DR   GeneID; 24675; -.
DR   KEGG; rno:24675; -.
DR   CTD; 5532; -.
DR   RGD; 3383; Ppp3cb.
DR   eggNOG; roNOG04245; -.
DR   GeneTree; ENSGT00530000063087; -.
DR   InParanoid; P20651; -.
DR   OrthoDB; EOG4PVNZK; -.
DR   PhylomeDB; P20651; -.
DR   NextBio; 604059; -.
DR   ArrayExpress; P20651; -.
DR   Genevestigator; P20651; -.
DR   GermOnline; ENSRNOG00000007757; Rattus norvegicus.
DR   GO; GO:0005626; C:insoluble fraction; IDA:RGD.
DR   GO; GO:0043234; C:protein complex; IDA:RGD.
DR   GO; GO:0005625; C:soluble fraction; IDA:RGD.
DR   GO; GO:0004723; F:calcium-dependent protein serine/threonine phosphatase activity; IDA:RGD.
DR   GO; GO:0005516; F:calmodulin binding; IDA:RGD.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046982; F:protein heterodimerization activity; IDA:RGD.
DR   GO; GO:0046716; P:muscle cell homeostasis; IEP:RGD.
DR   GO; GO:0006470; P:protein dephosphorylation; IDA:RGD.
DR   GO; GO:0001975; P:response to amphetamine; IEP:RGD.
DR   InterPro; IPR004843; Metallo_PEstase_dom.
DR   InterPro; IPR006186; Ser/Thr-sp_prot-phosphatase.
DR   Pfam; PF00149; Metallophos; 1.
DR   PRINTS; PR00114; STPHPHTASE.
DR   SMART; SM00156; PP2Ac; 1.
DR   PROSITE; PS00125; SER_THR_PHOSPHATASE; 1.
DR   HOGENOMDNA; RAT15.PE52; -.
KW   ENSRNOG00000007757820036002503210000011;
KW   Ppp3cb; PP2BB_RAT; D90036; M31809; M58441;
KW   Acetylation; Calmodulin-binding; Complete proteome; Hydrolase; Iron;
KW   Metal-binding; Protein phosphatase; Reference proteome; Zinc.
SQ   SEQUENCE   497 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     AVPFPPTHRL TSEEVFDMDG IPRVDVLKNH LVKEGRVDEE IALRIINEGA AILRREKTMI
     EVEAPITVCG DIHGQFFDLM KLFEVGGSPA NTRYLFLGDY VDRGYFSIEC VLYLWVLKIL
     YPSTLFLLRG NHECRHLTEY FTFKQECKIK YSERVYEACM EAFDSLPLAA LLNQQFLCVH
     GGLSPEIHTL DDIRRLDRFK EPPAFGPMCD LLWSDPSEDF GNEKSQEHFS HNTVRGCSYF
     YNYPAVCEFL QNNNLLSIIR AHEAQDAGYR MYRKSQTTGF PSLITIFSAP NYLDVYNNKA
     AVLKYENNVM NIRQFNCSPH PYWLPNFMDV FTWSLPFVGE KVTEMLVNVL SICSDDELMT
     EGEDQFDVGS AAARKEIIRN KIRAIGKMAR VFSVLREESE SVLTLKGLTP TGMLPSGVLA
     GGRQTLQSAT VEAIEAEKAI RGFSPPHRIC SFEEAKGLDR INERMPPRKD AVQQDGFNSL
     NTAHTTENHG TGNHSAQ
//

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