(data stored in ACNUC18777 zone)

HOGENOM: RAT16_PE691

ID   RAT16_PE691                          STANDARD;      PRT;   284 AA.
AC   RAT16_PE691; P97826; P97628;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Steroidogenic acute regulatory protein, mitochondrial;
DE   Short=StAR;AltName: Full=START domain-containing protein 1;
DE   Short=StARD1;Flags: Precursor; (RAT16.PE691).
GN   Name=Star;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT16.PE691.
CC       Rattus norvegicus chromosome 16 RGSC3.4  sequence 1..90238779
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:STAR_RAT
CC   -!- FUNCTION: Plays a key role in steroid hormone synthesis by
CC       enhancing the metabolism of cholesterol into pregnenolone.
CC       Mediates the transfer of cholesterol from the outer mitochondrial
CC       membrane to the inner mitochondrial membrane where it is cleaved
CC       to pregnenolone (By similarity).
CC   -!- PATHWAY: Steroid metabolism; cholesterol metabolism.
CC   -!- SUBUNIT: May interact with TSPO (By similarity).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion.
CC   -!- SIMILARITY: Contains 1 START domain.
CC   -!- GENE_FAMILY: HOG000142452 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000015052;ENSRNOT00000020606;ENSRNOP00000020606.
DR   EMBL; AB001349; - ;
DR   EMBL; AB006007; - ;
DR   EMBL; AF044081; - ;
DR   EMBL; AY736357; - ;
DR   EMBL; BC088859; - ;
DR   EMBL; EF091859; - ;
DR   EMBL; U76419; - ;
DR   UniProtKB/Swiss-Prot; P97826; P97628; -.
DR   EMBL; AB001349; BAA19245.1; -; mRNA.
DR   EMBL; U76419; AAB41674.1; -; mRNA.
DR   EMBL; AF044081; AAC02528.1; -; mRNA.
DR   EMBL; AB006007; BAA34737.1; -; mRNA.
DR   EMBL; BC088859; AAH88859.1; -; mRNA.
DR   IPI; IPI00208600; -.
DR   RefSeq; NP_113746.1; NM_031558.2.
DR   UniGene; Rn.11399; -.
DR   ProteinModelPortal; P97826; -.
DR   STRING; P97826; -.
DR   PhosphoSite; P97826; -.
DR   PRIDE; P97826; -.
DR   Ensembl; ENSRNOT00000020606; ENSRNOP00000020606; ENSRNOG00000015052.
DR   GeneID; 25557; -.
DR   KEGG; rno:25557; -.
DR   UCSC; NM_031558; rat.
DR   CTD; 6770; -.
DR   RGD; 3770; Star.
DR   InParanoid; P97826; -.
DR   OMA; QEGWKKE; -.
DR   OrthoDB; EOG4JWVF2; -.
DR   PhylomeDB; P97826; -.
DR   NextBio; 607131; -.
DR   ArrayExpress; P97826; -.
DR   Genevestigator; P97826; -.
DR   GermOnline; ENSRNOG00000015052; Rattus norvegicus.
DR   GO; GO:0005829; C:cytosol; IDA:RGD.
DR   GO; GO:0030061; C:mitochondrial crista; IDA:RGD.
DR   GO; GO:0005758; C:mitochondrial intermembrane space; IDA:RGD.
DR   GO; GO:0043005; C:neuron projection; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0017127; F:cholesterol transporter activity; TAS:RGD.
DR   GO; GO:0005515; F:protein binding; IPI:RGD.
DR   GO; GO:0006699; P:bile acid biosynthetic process; IDA:RGD.
DR   GO; GO:0018879; P:biphenyl metabolic process; IEP:RGD.
DR   GO; GO:0007420; P:brain development; IEP:RGD.
DR   GO; GO:0071312; P:cellular response to alkaloid; IEP:RGD.
DR   GO; GO:0071236; P:cellular response to antibiotic; IEP:RGD.
DR   GO; GO:0071276; P:cellular response to cadmium ion; IEP:RGD.
DR   GO; GO:0071320; P:cellular response to cAMP; IEP:RGD.
DR   GO; GO:0071549; P:cellular response to dexamethasone stimulus; IEP:RGD.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEP:RGD.
DR   GO; GO:0044344; P:cellular response to fibroblast growth factor stimulus; IEP:RGD.
DR   GO; GO:0071372; P:cellular response to follicle-stimulating hormone stimulus; IEP:RGD.
DR   GO; GO:0071333; P:cellular response to glucose stimulus; IEP:RGD.
DR   GO; GO:0071378; P:cellular response to growth hormone stimulus; IEP:RGD.
DR   GO; GO:0032869; P:cellular response to insulin stimulus; IEP:RGD.
DR   GO; GO:0035457; P:cellular response to interferon-alpha; IMP:RGD.
DR   GO; GO:0071346; P:cellular response to interferon-gamma; IEP:RGD.
DR   GO; GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0071373; P:cellular response to luteinizing hormone stimulus; IEP:RGD.
DR   GO; GO:0071407; P:cellular response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0071560; P:cellular response to transforming growth factor beta stimulus; IEP:RGD.
DR   GO; GO:0042747; P:circadian sleep/wake cycle, REM sleep; IEP:RGD.
DR   GO; GO:0018894; P:dibenzo-p-dioxin metabolic process; IEP:RGD.
DR   GO; GO:0016101; P:diterpenoid metabolic process; IEP:RGD.
DR   GO; GO:0006703; P:estrogen biosynthetic process; IMP:RGD.
DR   GO; GO:0050756; P:fractalkine metabolic process; IEP:RGD.
DR   GO; GO:0017143; P:insecticide metabolic process; IEP:RGD.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IEP:RGD.
DR   GO; GO:0008584; P:male gonad development; IEP:RGD.
DR   GO; GO:0018958; P:phenol-containing compound metabolic process; IEP:RGD.
DR   GO; GO:0018963; P:phthalate metabolic process; IEP:RGD.
DR   GO; GO:0045768; P:positive regulation of anti-apoptosis; IMP:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:RGD.
DR   GO; GO:0050769; P:positive regulation of neurogenesis; IMP:RGD.
DR   GO; GO:0006701; P:progesterone biosynthetic process; IEP:RGD.
DR   GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:RGD.
DR   GO; GO:0051412; P:response to corticosterone stimulus; IEP:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0043627; P:response to estrogen stimulus; IEP:RGD.
DR   GO; GO:0045471; P:response to ethanol; IEP:RGD.
DR   GO; GO:0060992; P:response to fungicide; IEP:RGD.
DR   GO; GO:0009635; P:response to herbicide; IEP:RGD.
DR   GO; GO:0042542; P:response to hydrogen peroxide; IEP:RGD.
DR   GO; GO:0010212; P:response to ionizing radiation; IEP:RGD.
DR   GO; GO:0010288; P:response to lead ion; IEP:RGD.
DR   GO; GO:0044321; P:response to leptin stimulus; IEP:RGD.
DR   GO; GO:0035094; P:response to nicotine; IEP:RGD.
DR   GO; GO:0007584; P:response to nutrient; IEP:RGD.
DR   GO; GO:0061370; P:testosterone biosynthetic process; IEP:RGD.
DR   InterPro; IPR000799; StAR.
DR   InterPro; IPR023393; START-like_dom.
DR   InterPro; IPR002913; START_lipid-bd.
DR   Gene3D; G3DSA:3.30.530.20; G3DSA:3.30.530.20; 1.
DR   Pfam; PF01852; START; 1.
DR   PRINTS; PR00978; STARPROTEIN.
DR   SMART; SM00234; START; 1.
DR   PROSITE; PS50848; START; 1.
DR   HOGENOMDNA; RAT16.PE691; -.
KW   ENSRNOG00000015052820036002503210000011;
KW   Star; STAR_RAT; A1E0X7_RAT; Q5XUN6_RAT; AB001349; AB006007; AF044081;
KW   BC088859; EF091859; U76419;
KW   Complete proteome; Lipid transport; Lipid-binding; Mitochondrion;
KW   Phosphoprotein; Reference proteome; Steroidogenesis; Transit peptide;
KW   Transport.
SQ   SEQUENCE   284 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLLATFKLCA GSSYRHMRNM KGLRHQAVLA IGQELNRRAL GDPSPGWMGQ VRRRSSLLGS
     QLEATLYSDQ ELSYIQQGEE AMQKALGILN NQEGWKKESQ QENGDEVLSK VVPGVGKVFR
     LEVLLDQPMD RLYEELVDRM EAMGEWNPNV KEIKVLKKIG KDTVITHELA AAAAGNLVGP
     RDFVSVRCTK RRGSTCVLAG MATHFGEMPE QSGVIRAEHG PTCMVLHPLA GSPSKTKLTW
     LLSIDLKGWL PKTIINQVLS QTQIEFASHL RKRLESSPAS EAQC
//

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