(data stored in ACNUC21429 zone)

HOGENOM: RAT17_PE121

ID   RAT17_PE121                          STANDARD;      PRT;   583 AA.
AC   RAT17_PE121; Q9JJP9; Q6IN34;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ubiquilin-1;AltName: Full=Protein linking IAP with
DE   cytoskeleton 1; Short=PLIC-1; (RAT17.PE121).
GN   Name=Ubqln1; Synonyms=Da41, Plic1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT17.PE121.
CC       Rattus norvegicus chromosome 17 RGSC3.4  sequence 1..97296363
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:UBQL1_RAT
CC   -!- FUNCTION: Links CD47 to the cytoskeleton. Promotes the surface
CC       expression of GABA-A receptors. Promotes the accumulation of
CC       uncleaved PSEN1 and PSEN2 by stimulating their biosynthesis. Has
CC       no effect on PSEN1 and PSEN2 degradation (By similarity).
CC   -!- SUBUNIT: Binds CD47, UBE3A, BTRC, P4HB, MTOR, PSEN1 and PSEN2.
CC       Interacts with the proteasome 19S subunit (By similarity). Binds
CC       NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3.
CC   -!- SUBCELLULAR LOCATION: Nucleus (By similarity). Cytoplasm.
CC       Note=Detected in neuronal processes and at synapses.
CC   -!- SIMILARITY: Contains 1 UBA domain.
CC   -!- SIMILARITY: Contains 1 ubiquitin-like domain.
CC   -!- GENE_FAMILY: HOG000234878 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000019282;ENSRNOT00000026277;ENSRNOP00000026277.
DR   EMBL; BC072477; - ;
DR   EMBL; D87950; - ;
DR   UniProtKB/Swiss-Prot; Q9JJP9; Q6IN34; -.
DR   EMBL; D87950; BAA92267.1; -; mRNA.
DR   EMBL; BC072477; AAH72477.1; -; mRNA.
DR   IPI; IPI00421876; -.
DR   RefSeq; NP_446199.2; NM_053747.2.
DR   UniGene; Rn.94864; -.
DR   PDB; 1KJV; X-ray; 1.48 A; P=450-458.
DR   PDBsum; 1KJV; -.
DR   ProteinModelPortal; Q9JJP9; -.
DR   SMR; Q9JJP9; 1-98, 530-579.
DR   STRING; Q9JJP9; -.
DR   PRIDE; Q9JJP9; -.
DR   GeneID; 114590; -.
DR   KEGG; rno:114590; -.
DR   UCSC; NM_053747; rat.
DR   CTD; 29979; -.
DR   RGD; 620745; Ubqln1.
DR   eggNOG; roNOG13844; -.
DR   GeneTree; ENSGT00390000005720; -.
DR   OrthoDB; EOG48KRBD; -.
DR   PhylomeDB; Q9JJP9; -.
DR   NextBio; 618741; -.
DR   Genevestigator; Q9JJP9; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISS:HGNC.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:HGNC.
DR   GO; GO:0000502; C:proteasome complex; IEA:UniProtKB-KW.
DR   GO; GO:0019904; F:protein domain specific binding; IPI:RGD.
DR   GO; GO:0006915; P:apoptosis; ISS:HGNC.
DR   GO; GO:0031396; P:regulation of protein ubiquitination; ISS:HGNC.
DR   GO; GO:0001666; P:response to hypoxia; ISS:HGNC.
DR   InterPro; IPR006636; STI1_HS-bd.
DR   InterPro; IPR009060; UBA-like.
DR   InterPro; IPR000449; UBA/transl_elong_EF1B_N.
DR   InterPro; IPR015940; UBA/transl_elong_EF1B_N_euk.
DR   InterPro; IPR015496; Ubiquilin.
DR   InterPro; IPR000626; Ubiquitin.
DR   InterPro; IPR019955; Ubiquitin_supergroup.
DR   PANTHER; PTHR10677; Ubiquilin; 1.
DR   Pfam; PF00627; UBA; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00727; STI1; 4.
DR   SMART; SM00165; UBA; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF46934; UBA_like; 1.
DR   PROSITE; PS50030; UBA; 1.
DR   PROSITE; PS00299; UBIQUITIN_1; FALSE_NEG.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
DR   HOGENOMDNA; RAT17.PE121; -.
KW   ENSRNOG00000019282820036002503210000011;
KW   UBQL1_RAT; BC072477; D87950;
KW   3D-structure; Acetylation; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Nucleus; Phosphoprotein; Proteasome;
KW   Reference proteome.
SQ   SEQUENCE   583 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAESAESGGP PGAQDSAADS GPAEPKIMKV TVKTPKEKEE FAVPENSSVQ QFKEEISKRF
     KSHIDQLVLI FAGKILKDQD TLSQHGIHDG LTVHLVIKTQ NRPQDNSAQQ TNTTGNSVTS
     SPAPDSNPTS GPAANSSFGL GGLGGLAGLS SLGLNTTNFS ELQSQMQRQL LSNPEMMVQI
     MENPFVQSML SNPDLMRQLI MANPQMQQLI QRNPEISHML NNPDIMRQTL ELARNPAMMQ
     EMMRNQDRAL SNLESIPGGY NALRRMYTDI QEPMLNAAQE QFGGNPFASL VSSPSSAEGT
     QPSRTENRDP LPNPWAPQTP QSSPASGSTG STTNTVSTSA GNATSTPAGQ GTSGPNLVPG
     AGDLSILYTP ALKAVLICIS LIPIMVINVL SPPWARKLLE VLSSNPRMGV QMMLNNPLFA
     GNPQLQEQMR QQLPTFLQQM QNPDTLSAMS NPRAMQALLQ IQQGLQTLAT EAPGLIPGFT
     PGLAAGNSGG PAGTTAPSTA PGEDTNPQGG AAEPGHQQFI QQMLQALAGV NPQLQSPEVR
     FQQQLEQLSA MGFLNREANL QALIATGGDI NAAIERLLGS QPS
//

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