(data stored in ACNUC7421 zone)

HOGENOM: RAT19_PE301

ID   RAT19_PE301                          STANDARD;      PRT;   369 AA.
AC   RAT19_PE301; Q5HZE4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Methylthioribose-1-phosphate isomerase; Short=M1Pi;
DE   Short=MTR-1-P isomerase; EC=5.3.1 23;AltName:
DE   Full=S-methyl-5-thioribose-1-phosphate isomerase;AltName:
DE   Full=Translation initiation factor eIF-2B subunit alpha/beta/delta-like
DE   protein; (RAT19.PE301).
GN   Name=Mri1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT19.PE301.
CC       Rattus norvegicus chromosome 19 RGSC3.4  sequence 1..59218465
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MTNA_RAT
CC   -!- FUNCTION: Catalyzes the interconversion of methylthioribose-1-
CC       phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P)
CC       (By similarity).
CC   -!- CATALYTIC ACTIVITY: S-methyl-5-thio-alpha-D-ribose 1-phosphate =
CC       S-methyl-5-thio-D-ribulose 1-phosphate.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via
CC       salvage pathway; L-methionine from S-methyl-5-thio-alpha-D-ribose
CC       1-phosphate: step 1/6.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the eIF-2B alpha/beta/delta subunits
CC       family. MtnA subfamily.
CC   -!- GENE_FAMILY: HOG000224730 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000026211;ENSRNOT00000003762;ENSRNOP00000003762.
DR   EMBL; BC089060; - ;
DR   UniProtKB/Swiss-Prot; Q5HZE4; -.
DR   EMBL; BC089060; AAH89060.1; -; mRNA.
DR   IPI; IPI00371283; -.
DR   RefSeq; NP_001010947.1; NM_001010947.1.
DR   UniGene; Rn.16390; -.
DR   HSSP; Q06489; 1W2W.
DR   ProteinModelPortal; Q5HZE4; -.
DR   STRING; Q5HZE4; -.
DR   PRIDE; Q5HZE4; -.
DR   Ensembl; ENSRNOT00000003762; ENSRNOP00000003762; ENSRNOG00000026211.
DR   GeneID; 288912; -.
DR   KEGG; rno:288912; -.
DR   NMPDR; fig|10116.3.peg.14766; -.
DR   UCSC; NM_001010947; rat.
DR   CTD; 84245; -.
DR   RGD; 1307789; Mri1.
DR   eggNOG; roNOG07599; -.
DR   GeneTree; ENSGT00390000013732; -.
DR   InParanoid; Q5HZE4; -.
DR   OMA; EDGWKVI; -.
DR   OrthoDB; EOG41C6WN; -.
DR   PhylomeDB; Q5HZE4; -.
DR   NextBio; 628955; -.
DR   ArrayExpress; Q5HZE4; -.
DR   Genevestigator; Q5HZE4; -.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0005634; C:nucleus; IBA:RefGenome.
DR   GO; GO:0046523; F:S-methyl-5-thioribose-1-phosphate isomerase activity; IBA:RefGenome.
DR   GO; GO:0019509; P:L-methionine salvage from methylthioadenosine; IBA:RefGenome.
DR   InterPro; IPR000649; IF-2B-related.
DR   InterPro; IPR005251; IF-2BI_MTNA.
DR   InterPro; IPR011559; Initiation_fac_2B_a/b/d.
DR   PANTHER; PTHR10233; IF-2B_related; 1.
DR   Pfam; PF01008; IF-2B; 1.
DR   TIGRFAMs; TIGR00524; EIF-2B_rel; 1.
DR   TIGRFAMs; TIGR00512; Salvage_mtnA; 1.
DR   HOGENOMDNA; RAT19.PE301; -.
KW   ENSRNOG00000026211820036002503210000011;
KW   Mri1; MTNA_RAT; BC089060;
KW   Amino-acid biosynthesis; Complete proteome; Cytoplasm; Isomerase;
KW   Methionine biosynthesis; Nucleus; Reference proteome.
SQ   SEQUENCE   369 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MRLEAIRYSP GSLQILDQLQ LPEHCHYETL SSVQQAREAI RAMKVRGAPA IALVGCLSLA
     VELQAGAGGP GLAALVAFVR DQLSLLVAAR PTAVNMARAA RDLTHMAARE AELEGATEET
     VRERVIRFAE DMLEKDLKDN RSIGDLGARH LLEQTNPRGG KVTVLTHCNT GALATAGYGT
     ALGVIRSLHE MGRLEHTFCT ETRPYNQGAR LTAFELVYEK IPATLITDSM AAAAMVHQGV
     SAVVVGADRV VANGDTANKI GTYQLAIVAK HHGIPFYVAA PSSSCDLRLE TGKEIVIEER
     PSQELTDLNG VRIAAQGIRV WNPAFDVTPH ELITGGIITE LGVFAPEELR AALSATIFSE
     GQTLDSPQM
//

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