(data stored in ACNUC26264 zone)

HOGENOM: RAT1_PE2142

ID   RAT1_PE2142                          STANDARD;      PRT;   328 AA.
AC   RAT1_PE2142; Q63371;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=P2Y purinoceptor 6; Short=P2Y6; (RAT1.PE2142).
GN   Name=P2ry6;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE2142.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:P2RY6_RAT
CC   -!- FUNCTION: Receptor for extracellular UTP > ADP = 2-methylthio-ATP
CC       > ADP-beta-S > ATP = ATP-gamma-S. The activity of this receptor is
CC       mediated by G proteins which activate a phosphatidylinositol-
CC       calcium second messenger system. Functionally coupled to
CC       phospholipase C.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Abundantly expressed in various tissues
CC       including lung, stomach, intestine, spleen, mesentery, heart, and,
CC       most prominently, aorta.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC   -!- GENE_FAMILY: HOG000231307 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000019270;ENSRNOT00000050227;ENSRNOP00000049439.
DR   EMBL; BC072520; - ;
DR   EMBL; D63665; - ;
DR   UniProtKB/Swiss-Prot; Q63371; -.
DR   EMBL; D63665; BAA09816.1; -; mRNA.
DR   EMBL; BC072520; AAH72520.1; -; mRNA.
DR   IPI; IPI00208052; -.
DR   PIR; I55450; I55450.
DR   RefSeq; NP_476465.1; NM_057124.2.
DR   UniGene; Rn.10671; -.
DR   ProteinModelPortal; Q63371; -.
DR   STRING; Q63371; -.
DR   Ensembl; ENSRNOT00000050227; ENSRNOP00000049439; ENSRNOG00000019270.
DR   GeneID; 117264; -.
DR   KEGG; rno:117264; -.
DR   UCSC; NM_057124; rat.
DR   CTD; 5031; -.
DR   RGD; 620269; P2ry6.
DR   eggNOG; maNOG15341; -.
DR   GeneTree; ENSGT00600000084187; -.
DR   InParanoid; Q63371; -.
DR   OMA; HGSILFL; -.
DR   OrthoDB; EOG4QVCCG; -.
DR   PhylomeDB; Q63371; -.
DR   NextBio; 620152; -.
DR   ArrayExpress; Q63371; -.
DR   Genevestigator; Q63371; -.
DR   GermOnline; ENSRNOG00000019270; Rattus norvegicus.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0016323; C:basolateral plasma membrane; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0045028; F:purinergic nucleotide receptor activity, G-protein coupled; IEA:InterPro.
DR   GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR002286; P2_purnocptor.
DR   InterPro; IPR001973; P2Y6_purnocptor.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01068; P2Y6PRNOCPTR.
DR   PRINTS; PR01157; P2YPURNOCPTR.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; FALSE_NEG.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; RAT1.PE2142; -.
KW   ENSRNOG00000019270820036002503210000011;
KW   P2ry6; P2RY6_RAT; BC072520; D63665;
KW   Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Receptor;
KW   Reference proteome; Transducer; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   328 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MERDNGTIQA PGLPPTTCVY REDFKRLLLP PVYSVVLVVG LPLNVCVIAQ ICASRRTLTR
     SAVYTLNLAL ADLLYACSLP LLIYNYARGD HWPFGDLACR LVRFLFYANL HGSILFLTCI
     SFQRYLGICH PLAPWHKRGG RRAAWVVCGV VWLVVTAQCL PTAVFAATGI QRNRTVCYDL
     SPPILSTRYL PYGMALTVIG FLLPFTALLA CYCRMARRLC RQDGPAGPVA QERRSKAARM
     AVVVAAVFVI SFLPFHITKT AYLAVRSTPG VSCPVLETFA AAYKGTRPFA SANSVLDPIL
     FYFTQQKFRR QPHDLLQKLT AKWQRQRV
//

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