(data stored in ACNUC17492 zone)

HOGENOM: RAT1_PE2826

ID   RAT1_PE2826                          STANDARD;      PRT;   181 AA.
AC   RAT1_PE2826; P49806;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Regulator of G-protein signaling 10; Short=RGS10;Flags:
DE   Fragment; (RAT1.PE2826).
GN   Name=Rgs10;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE2826.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RGS10_RAT
CC   -!- FUNCTION: Inhibits signal transduction by increasing the GTPase
CC       activity of G protein alpha subunits thereby driving them into
CC       their inactive GDP-bound form. Associates specifically with the
CC       activated forms of the G protein subunits G(i)-alpha and G(z)-
CC       alpha but fails to interact with the structurally and functionally
CC       distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited
CC       by palmitoylation of the G-protein (By similarity).
CC   -!- SIMILARITY: Contains 1 RGS domain.
CC   -!- GENE_FAMILY: HOG000233512 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000042592;ENSRNOT00000027375;ENSRNOP00000027375.
DR   EMBL; U32437; - ;
DR   UniProtKB/Swiss-Prot; P49806; -.
DR   EMBL; U32437; AAC52374.1; -; mRNA.
DR   IPI; IPI00876573; -.
DR   UniGene; Rn.23957; -.
DR   ProteinModelPortal; P49806; -.
DR   SMR; P49806; 1-66.
DR   STRING; P49806; -.
DR   PRIDE; P49806; -.
DR   RGD; 3562; Rgs10.
DR   eggNOG; maNOG06495; -.
DR   GeneTree; ENSGT00540000071162; -.
DR   OrthoDB; EOG4JM7QV; -.
DR   ArrayExpress; P49806; -.
DR   Genevestigator; P49806; -.
DR   GermOnline; ENSRNOG00000020271; Rattus norvegicus.
DR   GO; GO:0043679; C:axon terminus; IDA:RGD.
DR   GO; GO:0005737; C:cytoplasm; IBA:RefGenome.
DR   GO; GO:0043197; C:dendritic spine; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0005886; C:plasma membrane; IBA:RefGenome.
DR   GO; GO:0005096; F:GTPase activator activity; IBA:RefGenome.
DR   GO; GO:0004871; F:signal transducer activity; IEA:InterPro.
DR   GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR   GO; GO:0008277; P:regulation of G-protein coupled receptor protein signaling pathway; TAS:RGD.
DR   InterPro; IPR000342; Regulat_G_prot_signal.
DR   InterPro; IPR016137; Regulat_G_prot_signal_superfam.
DR   Pfam; PF00615; RGS; 1.
DR   PRINTS; PR01301; RGSPROTEIN.
DR   SUPFAM; SSF48097; Regulat_G_prot_signal_superfam; 1.
DR   PROSITE; PS50132; RGS; 1.
DR   HOGENOMDNA; RAT1.PE2826; -.
KW   ENSRNOG00000042592820036002503210000011;
KW   Rgs10; RGS10_RAT; U32437;
KW   Complete proteome; Lipoprotein; Palmitate; Reference proteome;
KW   Signal transduction inhibitor.
SQ   SEQUENCE   181 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MFTRAVSRLS RKRPPSDIHD GDGSSSSGHQ SLKSTAKWAS SLENLLEDPE GVKRFREFLK
     KEFSEENVLF WLACEDFKKT EDKKQMQEKA KKIYMTFLSN KASSQVNVEG QSRLTEKILE
     EPHPLMFQKL QDQIFNLMKY DSYSRFLKSD LFLKHRRTEE EEEDPPDAQT AAKRASRIYN
     T
//

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