(data stored in ACNUC1829 zone)

HOGENOM: RAT1_PE3126

ID   RAT1_PE3126                          STANDARD;      PRT;   236 AA.
AC   RAT1_PE3126; Q62745;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=CD81 antigen;AltName: Full=26 kDa cell surface protein
DE   TAPA-1;AltName: Full=Target of the antiproliferative antibody 1;AltName:
DE   CD_antigen=CD81; (RAT1.PE3126).
GN   Name=Cd81; Synonyms=Tapa1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE3126.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CD81_RAT
CC   -!- FUNCTION: May play an important role in the regulation of lymphoma
CC       cell growth.
CC   -!- SUBUNIT: Interacts directly with IGSF8 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC   -!- SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
CC   -!- GENE_FAMILY: HOG000230651 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000020451;ENSRNOT00000027760;ENSRNOP00000027760.
DR   EMBL; BC060583; - ;
DR   EMBL; CH473953; - ;
DR   EMBL; U19894; - ;
DR   UniProtKB/Swiss-Prot; Q62745; -.
DR   EMBL; U19894; AAC53103.1; -; mRNA.
DR   IPI; IPI00208154; -.
DR   RefSeq; NP_037219.1; NM_013087.1.
DR   UniGene; Rn.1975; -.
DR   ProteinModelPortal; Q62745; -.
DR   SMR; Q62745; 113-201.
DR   STRING; Q62745; -.
DR   PRIDE; Q62745; -.
DR   GeneID; 25621; -.
DR   KEGG; rno:25621; -.
DR   UCSC; NM_013087; rat.
DR   CTD; 975; -.
DR   RGD; 2315; Cd81.
DR   eggNOG; roNOG11432; -.
DR   InParanoid; Q62745; -.
DR   OrthoDB; EOG4X97J1; -.
DR   NextBio; 607393; -.
DR   ArrayExpress; Q62745; -.
DR   Genevestigator; Q62745; -.
DR   GermOnline; ENSRNOG00000020451; Rattus norvegicus.
DR   GO; GO:0016324; C:apical plasma membrane; IDA:RGD.
DR   GO; GO:0005887; C:integral to plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005515; F:protein binding; IPI:UniProtKB.
DR   GO; GO:0000187; P:activation of MAPK activity; ISS:UniProtKB.
DR   GO; GO:0006661; P:phosphatidylinositol biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0043128; P:positive regulation of 1-phosphatidylinositol 4-kinase activity; ISS:UniProtKB.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; ISS:UniProtKB.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; ISS:UniProtKB.
DR   GO; GO:0008104; P:protein localization; ISS:UniProtKB.
DR   GO; GO:0040008; P:regulation of growth; IEP:RGD.
DR   GO; GO:0009611; P:response to wounding; IEP:RGD.
DR   InterPro; IPR023396; CD81_extracellular.
DR   InterPro; IPR018499; Tetraspanin.
DR   InterPro; IPR018503; Tetraspanin_CS.
DR   InterPro; IPR008952; Tetraspanin_EC2.
DR   InterPro; IPR000301; Tetraspanin_subgr.
DR   Gene3D; G3DSA:1.10.1450.10; G3DSA:1.10.1450.10; 1.
DR   Pfam; PF00335; Tetraspannin; 1.
DR   PRINTS; PR00259; TMFOUR.
DR   SUPFAM; SSF48652; Tetraspanin; 1.
DR   PROSITE; PS00421; TM4_1; 1.
DR   HOGENOMDNA; RAT1.PE3126; -.
KW   ENSRNOG00000020451820036002503210000011;
KW   CD81_RAT; Q6P9V1_RAT; BC060583; CH473953; U19894;
KW   Complete proteome; Direct protein sequencing; Disulfide bond;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   236 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGVEGCTKCI KYLLFVFNFV FWLAGGVILG VALWLRHDPQ TTSLLYLELG DKPAPSTFYV
     GIYILIAVGA VMMFVGFLGC YGAIQESQCL LGTFFTCLVI LFACEVAAGI WGFVNKDQIA
     KDVKQFYDQA LQQAVMDDDA NNAKAVVKTF HETLNCCGSN TLTTLTTTVL RNSLCPSSSN
     SFTQLLKEDC HQKIDELFSG KLYLIGIAAI VVAVIMIFEM ILSMVLCCGI RNSSVY
//

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