(data stored in ACNUC32233 zone)

HOGENOM: RAT1_PE3246

ID   RAT1_PE3246                          STANDARD;      PRT;   2388 AA.
AC   RAT1_PE3246; Q9QWN8; O88197; Q9ES68;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Spectrin beta chain, brain 2;AltName: Full=Beta SpIII sigma
DE   1;AltName: Full=Beta-III spectrin;AltName: Full=Glutamate transporter
DE   EAAT4-associated protein 41;AltName: Full=SPNB-3;AltName: Full=Spectrin,
DE   non-erythroid beta chain 2;AltName: Full=Spectrin-like protein GTRAP41;
DE   (RAT1.PE3246).
GN   Name=Sptbn2; Synonyms=Spnb3;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE3246.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:SPTN2_RAT
CC   -!- FUNCTION: Probably plays an important role in neuronal membrane
CC       skeleton.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Cytoplasm, cell
CC       cortex.
CC   -!- TISSUE SPECIFICITY: Abundantly transcribed in the brain. Neurons
CC       are the predominant cell-type to express the gene. Found
CC       abundantly in Purkinje cells.
CC   -!- SIMILARITY: Belongs to the spectrin family.
CC   -!- SIMILARITY: Contains 2 CH (calponin-homology) domains.
CC   -!- SIMILARITY: Contains 1 PH domain.
CC   -!- SIMILARITY: Contains 17 spectrin repeats.
CC   -!- GENE_FAMILY: HOG000007281 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000019564;ENSRNOT00000026573;ENSRNOP00000026573.
DR   EMBL; AB001347; - ;
DR   EMBL; AB008551; - ;
DR   EMBL; AF225960; - ;
DR   UniProtKB/Swiss-Prot; Q9QWN8; O88197; Q9ES68; -.
DR   EMBL; AB008551; BAA32699.1; -; mRNA.
DR   EMBL; AB001347; BAA32473.1; -; mRNA.
DR   EMBL; AF225960; AAG28596.1; -; mRNA.
DR   IPI; IPI00327662; -.
DR   PIR; JE0271; JE0271.
DR   RefSeq; NP_062040.1; NM_019167.1.
DR   UniGene; Rn.20389; -.
DR   ProteinModelPortal; Q9QWN8; -.
DR   SMR; Q9QWN8; 48-291, 1068-1277, 2212-2333.
DR   STRING; Q9QWN8; -.
DR   PhosphoSite; Q9QWN8; -.
DR   PRIDE; Q9QWN8; -.
DR   GeneID; 29211; -.
DR   KEGG; rno:29211; -.
DR   UCSC; NM_019167; rat.
DR   CTD; 6712; -.
DR   RGD; 3751; Sptbn2.
DR   eggNOG; maNOG14440; -.
DR   GeneTree; ENSGT00560000077093; -.
DR   InParanoid; Q9QWN8; -.
DR   OrthoDB; EOG43FGW0; -.
DR   NextBio; 608384; -.
DR   ArrayExpress; Q9QWN8; -.
DR   Genevestigator; Q9QWN8; -.
DR   GermOnline; ENSRNOG00000019564; Rattus norvegicus.
DR   GO; GO:0005829; C:cytosol; TAS:Reactome.
DR   GO; GO:0016363; C:nuclear matrix; TAS:UniProtKB.
DR   GO; GO:0008091; C:spectrin; TAS:UniProtKB.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0005200; F:structural constituent of cytoskeleton; TAS:UniProtKB.
DR   GO; GO:0051693; P:actin filament capping; IEA:UniProtKB-KW.
DR   GO; GO:0017158; P:regulation of calcium ion-dependent exocytosis; TAS:UniProtKB.
DR   GO; GO:0016081; P:synaptic vesicle docking involved in exocytosis; TAS:UniProtKB.
DR   InterPro; IPR001589; Actinin_actin-bd_CS.
DR   InterPro; IPR001715; CH-domain.
DR   InterPro; IPR011993; PH_type.
DR   InterPro; IPR001849; Pleckstrin_homology.
DR   InterPro; IPR018159; Spectrin/alpha-actinin.
DR   InterPro; IPR016343; Spectrin_bsu.
DR   InterPro; IPR001605; Spectrin_PH.
DR   InterPro; IPR002017; Spectrin_repeat.
DR   Gene3D; G3DSA:1.10.418.10; Calponin-homology; 2.
DR   Gene3D; G3DSA:2.30.29.30; PH_type; 1.
DR   Pfam; PF00307; CH; 2.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00435; Spectrin; 17.
DR   PIRSF; PIRSF002297; Spectrin_beta_subunit; 1.
DR   PRINTS; PR00683; SPECTRINPH.
DR   SMART; SM00033; CH; 2.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00150; SPEC; 17.
DR   SUPFAM; SSF47576; Calponin-homology; 1.
DR   PROSITE; PS00019; ACTININ_1; 1.
DR   PROSITE; PS00020; ACTININ_2; 1.
DR   PROSITE; PS50021; CH; 2.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   HOGENOMDNA; RAT1.PE3246; -.
KW   ENSRNOG00000019564820036002503210000011;
KW   Sptbn2; SPTN2_RAT; AB001347; AB008551; AF225960;
KW   Actin capping; Actin-binding; Complete proteome; Cytoplasm;
KW   Cytoskeleton; Phosphoprotein; Reference proteome; Repeat.
SQ   SEQUENCE   2388 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MSSTLSPTDF DSLEIQGQYS DINNRWDLPD SDWDNDSSSA RLFERSRIKA LADEREAVQK
     KTFTKWVNSH LARVTCRVGD LYSDLRDGRN LLRLLEVLSG ETLPKPTKGR MRIHCLENVD
     KALQFLKEQK VHLENMGSHD IVDGNHRLTL GLVWTIILRF QIQDISVETE DNKEKKSAKD
     ALLLWCQMKT AGYPNVNVHN FTTSWRDGLA FNAIVHKHRP DLLDFESLKK CNAHYNLQNA
     FNLAEKELGL TKLLDPEDVN VDQPDEKSII TYVATYYHYF SKMKALAVEG KRIGKVLDHA
     MEAEHLVEKY ESLASELLQW IEQTIVTLND RQLANSLSGV QNQLQSFNSY RTVEKPPKFT
     EKGNLEVLLF TIQSKLRANN QKVYTPREGR LISDINKAWE RLEKAEHERE LALRTELIRQ
     EKLEQLAARF DRKAAMRETW LSENQRLVSQ DNFGLELAAV EAAVRKHEAI ETDIVAYSGR
     VQAVDAVAAE LAAEHYHDIK RIAARQNNVA RLWDFLREMV AARRERLLLN LELQKVFQDL
     LSLMDWMAEM KGRLQSQDLG KHLAGVEDLL QLHELVEADI AVQAERVRAV SASALRFCDP
     GKEYRPCDPQ LVSERVATLE QSYEALCELA ATRRARLEES RRLWRFLWEV GEAEAWVREQ
     QHLLASAETG RDLTGVLRLL NKHTALRGEM SGRLGPLKLT LEQGQQLVAE GHPGANQAST
     RAAELQAQWE RLEALAEERA QRLAQAASLY QFQADANDME AWLVDALRLV SSPEVGHDEF
     STQALARQHR ALEEEIRAHR PTLDALREQA AALPPALSHT PEVQGRVPTL EQHYEELQAR
     AGERARALEA ALAFYTMLSE AGACGLWVEE KEQWLNGLAL PERLEDLEVV QQRFETLEPE
     MNALAARVTA VSDIAEQLLK ASPPGKDRII GTQEQLNQRW QQFRSLADGK KAALTSALSI
     QNYHLECTET QAWMREKTKV IESTQDLGND LAGVLALQRK LAGTERDLEA ISARVGELTQ
     EANALAAGHP AQAPAINTRL GEVQTGWEDL RATMRRREES LGEARRLQDF LRSLDDFQAW
     LGRTQTAVAS EEGPATLPEA EALLAQHAAL RGEVERAQSE YSRLRTLGEE VTRDQADPQC
     LFLRQRLEAL GTGWEELGRM WESRQGRLAQ AHGFQGFLRD ARQAEGVLSS QEYVLSHTEM
     PGTLQAADAA IKKLEDFMST MDANGERIRG LLEAGRQLVS KGNIHAEKIQ EKADSIEKRH
     RKNQEAVQQL LGRLRDNREQ QHFLQDCQEL KLWIDEKMLT AQDVSYDEAR NLHTKWQKHQ
     AFMAELAANK DWLDKVDKEG RELTLEKPEL KVLVSEKLED LHRRWDELET TTQAKARSLF
     DANRAELFAQ SCSALESWLE SLQAQLHSDD YGKDLTSVNI LLKKQQMLER EMAVREKEVE
     AIQAQAKALA QEDQSAGEVE RTSRAVEEKF RALCQPMKDR CRRLQASREQ HQFHRDVEDE
     ILWVTERLPM ASSLEHGKDL PSVQLLMKKN QTLQKEIQGH EPRIADLKER QRTLGTAAAG
     PELAELQEMW KRLSHELELR GKRLEEALRA QQFYRDAAEA EAWMGEQELH MMGQEKAKDE
     LSAQAEVKKH QVLEQALADY AQTIKQLAAS SQDMIDHEHP ESTRLTIRQA QVDKLYAGLK
     ELAGERRERL QEHLRLCQLR RELDDLEQWI QEREVVAASH ELGQDYEHVT MLRDKFREFS
     RDTSTIGQER VDSANALANG LIAGGHAARA TVAEWKDSLN EAWADLLELL DTRGQVLAAA
     YELQRFLHGA RQALARVQHK QQQLPDGTGR DLNAAEALQR RHCAYEHDIQ ALSTQVQQVQ
     DDGLRLQKAY AGDKAEEIGR HMQAVAEAWA QLQGSSAARR QLLLDTTDKF RFFKAVRELM
     LWMDGINLQM DAQERPRDVS SADLVIKNQQ GIKAEIEARA DRFSACIDMG QELLARNHYA
     AEEISEKLSQ LQSRRQETAE KWQEKMDWLQ LVLEVLVFGR DAGMAEAWLC SQEPLVRSAE
     LGCTVDEVES LIKRHEAFQK SAVAWEERFS ALEKLTALEE RENEQKRKRE EEERRKQPPT
     SEPMASQPEG SLVDGQRVLD TAWDGTQSKL PPSTQAPSIN GVCTDTESSQ PLLEQQRLEQ
     SNVPEGPGSG TGDESSGPRG ERQTLPRGPA PSPMPQSRSS ESAHVATLPA RGAELSAQEQ
     MEGTLCRKQE MEAFNKKAAN RSWQNVYCVL RRGSLGFYKD ARAASAGVPY HGEVPVSLAR
     AQGSVAFDYR KRKHVFKLGL QDGKEYLFQA KDEAEMSSWL RVVNAAIATA SSASGEPEEP
     VVPSASRGLT RAMTMPPVSQ PEGSIVLRSK DGREREREKR FSFFKKNK
//

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