(data stored in ACNUC20591 zone)

HOGENOM: RAT1_PE3318

ID   RAT1_PE3318                          STANDARD;      PRT;   1040 AA.
AC   RAT1_PE3318; Q6I7S1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   SubName: Full=GTPase-activating protein; (RAT1.PE3318).
GN   Name=Sipa1; Synonyms=SPA-1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE3318.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:Q6I7S1_RAT
CC   -!- SIMILARITY: Contains 1 PDZ (DHR) domain.
CC   -!- GENE_FAMILY: HOG000154327 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000020726;ENSRNOT00000028137;ENSRNOP00000028137.
DR   EMBL; AB091474; - ;
DR   UniProtKB/Swiss-Prot; Q6I7S1; -.
DR   EMBL; AB091474; BAD23902.1; -; mRNA.
DR   IPI; IPI00366158; -.
DR   RefSeq; NP_001004089.1; NM_001004089.1.
DR   UniGene; Rn.24935; -.
DR   ProteinModelPortal; Q6I7S1; -.
DR   STRING; Q6I7S1; -.
DR   PhosphoSite; Q6I7S1; -.
DR   GeneID; 361710; -.
DR   KEGG; rno:361710; -.
DR   CTD; 6494; -.
DR   RGD; 1303184; Sipa1.
DR   eggNOG; maNOG17954; -.
DR   GeneTree; ENSGT00550000074284; -.
DR   InParanoid; Q6I7S1; -.
DR   OrthoDB; EOG4XPQF5; -.
DR   NextBio; 677353; -.
DR   ArrayExpress; Q6I7S1; -.
DR   Genevestigator; Q6I7S1; -.
DR   GO; GO:0043234; C:protein complex; IDA:RGD.
DR   GO; GO:0030133; C:transport vesicle; IDA:RGD.
DR   GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR   GO; GO:0008022; F:protein C-terminus binding; IPI:RGD.
DR   GO; GO:0042631; P:cellular response to water deprivation; IDA:RGD.
DR   GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR   InterPro; IPR001478; PDZ/DHR/GLGF.
DR   InterPro; IPR000331; Rap_GAP.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF02145; Rap_GAP; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; PDZ; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50085; RAPGAP; 1.
DR   HOGENOMDNA; RAT1.PE3318; -.
KW   ENSRNOG00000020726820036002503210000011;
KW   Sipa1; Q6I7S1_RAT; AB091474.
SQ   SEQUENCE   1040 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MWAGGVGSPR RGMAPAPTDD LFARKLRQPA RPPLTPHTFE PRPARGPLLR SGSDAGEVRP
     PTPASPRARA HSHEDTSRPA ATPTRLFTDP LALLGLPAEE PEPTFPPVLE PRWFAHYDVQ
     SLLFDWAPRP RATGSHTESN SGTLALAEDQ TTTSDLLLGA PGFVSELGGE GELGLGGPIS
     PPVPPALPNA SVSVLEEPQT RTTAYSLEHA DLGAGYYRKY FYGKEHQNFF GLDEALGPVA
     VSLRREEKEG SGGGTLHSYR VIVRTTQLRT LRGTISEDAL PPGPPRGLSP RKLLEHVAPR
     LSPTCLRLGS ASPKVPRTLL TLDEQVLSFQ RKVGILYCRA GQGSEEEMYN NQEAGAAFMQ
     FLTLLGDVVR LKGFENYRAQ LDTKTDSTGT HSLYTTYQDH EIMFHVSTML PYTPNNQQQL
     LRKRHIGNDI VTIVFQEPGS KPFCPTTIRS HFQHVFLVVR AHAPCTPHTS YRVAVSRTQD
     TPAFGPALPE GGGPFAANAD FRAFLLAKAL NGEQAAGHAR QFHAMATRTR QQYLQDLATN
     EVTTTSLDSA SRFGLPSLGG RRRATPRSPG AELQAAGALM WGVRAAPGAR VSAGAETGGP
     DHAEVPCLLG ISAETLVLVT PRDGRVVFNC ACRDVLAWTF SDHQLDLYHG RGEAITLRLD
     GAPGQAVGEV VARLQLVSRG CETRELALPR DGQGRLGFEV DAEGFITHVE RFTFAETTGL
     RPGARLLRVC GQTLPKLGPE AAAQMLRSAS KVCVTVLPPD ESGRPRRSFS ELYTLSLKEP
     SRRAAPEPEQ DETEKLVTLP AAKQLLHFCL KDGGSPPGPG DLTEERTEFL HSHNSLSPRS
     SMSDEAPVLP NTTPDLLLVT AVTTLAPGTD RETPPSQDQS GSSSSHEDTS DSAPELRASI
     LPRTLSLRNS ISKIMSEAGS ETLEDEWQSI SEIASTCNTI LESLSREGQP ILESGDPKET
     SKCNSEPEPG SLSEKVSHLE SMLRKLQEDL QREKADRAAL EEEVRSLRHN NQRLLAESES
     AATRLLLASK QLGSPTTDLA
//

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