(data stored in ACNUC21562 zone)

HOGENOM: RAT1_PE388

ID   RAT1_PE388                           STANDARD;      PRT;   324 AA.
AC   RAT1_PE388; P12526;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Proto-oncogene Mas; (RAT1.PE388).
GN   Name=Mas1; Synonyms=Mas, Mas-1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE388.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MAS_RAT
CC   -!- FUNCTION: Receptor for angiotensin 1-7 (By similarity). Acts
CC       specifically as a functional antagonist of AGTR1 (angiotensin-2
CC       type 1 receptor), although it up-regulates AGTR1 receptor levels.
CC       Positive regulation of AGTR1 levels occurs through activation of
CC       the G-proteins GNA11 and GNAQ, and stimulation of the protein
CC       kinase C signaling cascade. The antagonist effect on AGTR1
CC       function is probably due to AGTR1 being physically altered by MAS1
CC       (By similarity).
CC   -!- SUBUNIT: Interacts with AGTR1 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Expressed in platelets.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC   -!- GENE_FAMILY: HOG000015412 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000014971;ENSRNOT00000020100;ENSRNOP00000020100.
DR   EMBL; BC078884; - ;
DR   EMBL; J03823; - ;
DR   UniProtKB/Swiss-Prot; P12526; -.
DR   EMBL; J03823; AAA41573.1; -; Genomic_DNA.
DR   EMBL; BC078884; AAH78884.1; -; mRNA.
DR   IPI; IPI00198560; -.
DR   PIR; A31816; TVRTAS.
DR   RefSeq; NP_036889.1; NM_012757.2.
DR   UniGene; Rn.21943; -.
DR   ProteinModelPortal; P12526; -.
DR   STRING; P12526; -.
DR   PhosphoSite; P12526; -.
DR   PRIDE; P12526; -.
DR   Ensembl; ENSRNOT00000020100; ENSRNOP00000020100; ENSRNOG00000014971.
DR   GeneID; 25153; -.
DR   KEGG; rno:25153; -.
DR   UCSC; NM_012757; rat.
DR   CTD; 4142; -.
DR   RGD; 3049; Mas1.
DR   eggNOG; roNOG14620; -.
DR   GeneTree; ENSGT00550000074531; -.
DR   InParanoid; P12526; -.
DR   OMA; DEMQPRR; -.
DR   OrthoDB; EOG4SJ5F8; -.
DR   PhylomeDB; P12526; -.
DR   NextBio; 605603; -.
DR   ArrayExpress; P12526; -.
DR   Genevestigator; P12526; -.
DR   GermOnline; ENSRNOG00000014971; Rattus norvegicus.
DR   GO; GO:0009986; C:cell surface; IDA:RGD.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0001595; F:angiotensin receptor activity; IMP:RGD.
DR   GO; GO:0017046; F:peptide hormone binding; IMP:RGD.
DR   GO; GO:0071375; P:cellular response to peptide hormone stimulus; IEP:RGD.
DR   GO; GO:0021766; P:hippocampus development; IEP:RGD.
DR   GO; GO:0008584; P:male gonad development; IEP:RGD.
DR   GO; GO:0001933; P:negative regulation of protein phosphorylation; IMP:RGD.
DR   GO; GO:0008284; P:positive regulation of cell proliferation; IDA:RGD.
DR   GO; GO:0045740; P:positive regulation of DNA replication; IDA:RGD.
DR   GO; GO:0060732; P:positive regulation of inositol phosphate biosynthetic process; IDA:RGD.
DR   GO; GO:0014823; P:response to activity; IEP:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0034698; P:response to gonadotropin stimulus; IEP:RGD.
DR   GO; GO:0007283; P:spermatogenesis; IMP:RGD.
DR   InterPro; IPR000276; 7TM_GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_supfam.
DR   InterPro; IPR000820; Mas_TM.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00533; MASONCOGENE.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
DR   HOGENOMDNA; RAT1.PE388; -.
KW   ENSRNOG00000014971820036002503210000011;
KW   Mas1; MAS_RAT; BC078884; J03823;
KW   Cell membrane; Complete proteome; G-protein coupled receptor;
KW   Glycoprotein; Membrane; Proto-oncogene; Receptor; Reference proteome;
KW   Transducer; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   324 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MDQSNMTSFA EEKAMNTSSR NASLGTSHPP IPIVHWVIMS ISPLGFVENG ILLWFLCFRM
     RRNPFTVYIT HLSIADISLL FCIFILSIDY ALDYELSSGH YYTIVTLSVT FLFGYNTGLY
     LLTAISVERC LSVLYPIWYR CHRPKHQSAF VCALLWALSC LVTTMEYVMC IDSGEESHSQ
     SDCRAVIIFI AILSFLVFTP LMLVSSTILV VKIRKNTWAS HSSKLYIVIM VTIIIFLIFA
     MPMRVLYLLY YEYWSTFGNL HNISLLFSTI NSSANPFIYF FVGSSKKKRF RESLKVVLTR
     AFKDEMQPRR QEGNGNTVSI ETVV
//

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