(data stored in ACNUC24361 zone)

HOGENOM: RAT1_PE838

ID   RAT1_PE838                           STANDARD;      PRT;   822 AA.
AC   RAT1_PE838; Q4V8E9;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Neurotrophin receptor-interacting factor 1;AltName:
DE   Full=Zinc finger protein 110; (RAT1.PE838).
GN   Name=Nrif1; Synonyms=Zfp110;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT1.PE838.
CC       Rattus norvegicus chromosome 1 RGSC3.4  sequence 1..267910886
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:NRIF1_RAT
CC   -!- FUNCTION: Transcription regulator which may participate in
CC       NGFR/p75(NTR)-mediated apoptosis. Probably acts as a transcription
CC       repressor: specifically binds to the 3'-end of zinc-finger coding
CC       genes and recruiting chromatin-modifying proteins such as SETDB1
CC       and TRIM28/KAP1, leading to transcription repression (By
CC       similarity).
CC   -!- SUBUNIT: Interacts with NGFR/p75(NTR) (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus,
CC       nucleolus (By similarity).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 5 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 2 KRAB domains.
CC   -!- SIMILARITY: Contains 1 SCAN box domain.
CC   -!- GENE_FAMILY: HOG000234619 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000031328;ENSRNOT00000026298;ENSRNOP00000026298.
DR   EMBL; BC097420; - ;
DR   UniProtKB/Swiss-Prot; Q4V8E9; -.
DR   EMBL; BC097420; AAH97420.1; -; mRNA.
DR   IPI; IPI00553915; -.
DR   RefSeq; NP_001019946.1; NM_001024775.1.
DR   UniGene; Rn.204252; -.
DR   ProteinModelPortal; Q4V8E9; -.
DR   SMR; Q4V8E9; 760-812.
DR   STRING; Q4V8E9; -.
DR   Ensembl; ENSRNOT00000026298; ENSRNOP00000026298; ENSRNOG00000031328.
DR   GeneID; 308362; -.
DR   KEGG; rno:308362; -.
DR   UCSC; NM_001024775; rat.
DR   CTD; 65020; -.
DR   RGD; 1306339; Zfp110.
DR   eggNOG; roNOG12401; -.
DR   GeneTree; ENSGT00530000063367; -.
DR   InParanoid; Q4V8E9; -.
DR   PhylomeDB; Q4V8E9; -.
DR   NextBio; 658700; -.
DR   ArrayExpress; Q4V8E9; -.
DR   Genevestigator; Q4V8E9; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006915; P:apoptosis; IEA:UniProtKB-KW.
DR   GO; GO:0016032; P:viral reproduction; IEA:InterPro.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR008916; Retrov_capsid_C.
DR   InterPro; IPR003309; Tscrpt_reg_SCAN.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 5.
DR   Pfam; PF01352; KRAB; 2.
DR   Pfam; PF02023; SCAN; 1.
DR   Pfam; PF00096; zf-C2H2; 4.
DR   SMART; SM00349; KRAB; 2.
DR   SMART; SM00431; SCAN; 1.
DR   SMART; SM00355; ZnF_C2H2; 5.
DR   SUPFAM; SSF109640; Krueppel-associated_box; 2.
DR   SUPFAM; SSF47353; Retrov_capsid_C; 1.
DR   PROSITE; PS50805; KRAB; 2.
DR   PROSITE; PS50804; SCAN_BOX; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
DR   HOGENOMDNA; RAT1.PE838; -.
KW   ENSRNOG00000031328820036002503210000011;
KW   Zfp110; Q4V8E9_RAT; BC097420;
KW   Apoptosis; Complete proteome; Cytoplasm; DNA-binding; Metal-binding;
KW   Nucleus; Reference proteome; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
SQ   SEQUENCE   822 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASTLPTTWP HESVKFEDVS LTFTKEEWAQ LDLQQKCLYR EIMMENYNNM ISVEHHFSKP
     NVISQLEEAE DCWPMEREIR QDILPECSGP SLDPGMNSFP AESPLMKIKV VEVLTLNKDV
     AGPRNALIQS LYPESRENLN PGNLKPAKPS KRLTDTEALR QKFRHFQYEE SAGPQKAVSR
     LRKLCHQWLQ PNIRSKKQII ELLVFEQFLS ALPEKFRVWL ESQHPEDCRA AVALLENMTS
     VTKDDAQLVC SSEATDQLKE KRKDVATLPV TVPPEEPVTF QDVAVGFSQE EWRLLGPVQR
     TEYHDVMLET LGNLVSVGWE PTLENRAISP DSPIPVVKPI HDPNPKDLSR NGIQSTVFEI
     ISQDRVQEIH TIESNQAGLL QEKSHPQKKL SESSKSQEGT NLHKSQGSLD EVPPRKHVKV
     KQKGTRKGKD RKNTISMTRG LRIRNQQKDS VEWQGRGDSN PMTHGYSIKN QRGSEQGTAG
     ARRDPITLTV SAQFYQKATG SEEGRFRDNS NAIVPDTPTK IHQKSPEWHK VGRSNNSMSS
     VQNDQMGSGA GRGRDNTILT HALPVKIHQK GYEEGKVQGN RNSLRHVKAH QKGSKGERVR
     ELSTSEKHVP YIKNHLKTSE REKGRENNDS IKYGPYIKTC YRGSEVRKLR RANNCTKAIS
     RHAQQIFFIK IHKGSQVCRC SECGKMFRNS RYFSVHKKIH TGERPYMCMA CGKAFVQSSS
     LTQHLRIHSG ERPFECSECG RTFNDRSAIS QHLRTHTGAK PYHCQHCGKA FRQSSHLTRH
     ERTHTGERPY VCSNCGKAFT QSSHLIGHQK THRIKFKKQP KL
//

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