(data stored in ACNUC9435 zone)

HOGENOM: RAT20_PE613

ID   RAT20_PE613                          STANDARD;      PRT;   470 AA.
AC   RAT20_PE613; P51774; Q54AG4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Early growth response protein 2; Short=EGR-2;AltName:
DE   Full=Zinc finger protein Krox-20; (RAT20.PE613).
GN   Name=Egr2; Synonyms=Egr-2, Krox-20, Krox20;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT20.PE613.
CC       Rattus norvegicus chromosome 20 RGSC3.4  sequence 1..55268282
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:EGR2_RAT
CC   -!- FUNCTION: Sequence-specific DNA-binding transcription factor.
CC       Binds to two specific DNA sites located in the promoter region of
CC       HOXA4. Binds to the promoter region of ERBB2 (By similarity).
CC   -!- SUBUNIT: Interacts with HCFC1. Interacts with WWP2. Interacts with
CC       CITED1. Interacts (via phosphorylated form) with SFN (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=Long;
CC         IsoId=P51774-1; Sequence=Displayed;
CC       Name=Short;
CC         IsoId=P51774-2; Sequence=VSP_006865;
CC   -!- PTM: Ubiquitinated by WWP2 leading to proteasomal degradation (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the EGR C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 3 C2H2-type zinc fingers.
CC   -!- GENE_FAMILY: HOG000036856 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000000640;ENSRNOT00000000792;ENSRNOP00000000792.
DR   EMBL; AB032419; - ;
DR   EMBL; AB032420; - ;
DR   EMBL; AB264614; - ;
DR   EMBL; D83508; - ;
DR   EMBL; U78102; - ;
DR   UniProtKB/Swiss-Prot; P51774; Q54AG4; -.
DR   EMBL; U78102; AAB36783.1; -; mRNA.
DR   EMBL; D83508; BAA11932.1; -; mRNA.
DR   EMBL; AB032420; BAA89319.1; -; mRNA.
DR   IPI; IPI00205353; -.
DR   IPI; IPI00231231; -.
DR   PIR; JC4716; JC4716.
DR   RefSeq; NP_446085.1; NM_053633.1.
DR   UniGene; Rn.89235; -.
DR   ProteinModelPortal; P51774; -.
DR   SMR; P51774; 334-420.
DR   STRING; P51774; -.
DR   Ensembl; ENSRNOT00000000792; ENSRNOP00000000792; ENSRNOG00000000640.
DR   GeneID; 114090; -.
DR   KEGG; rno:114090; -.
DR   UCSC; D83508; rat.
DR   CTD; 1959; -.
DR   RGD; 621608; Egr2.
DR   InParanoid; P51774; -.
DR   OMA; GNEGPRL; -.
DR   OrthoDB; EOG41NTMJ; -.
DR   PhylomeDB; P51774; -.
DR   NextBio; 618219; -.
DR   ArrayExpress; P51774; -.
DR   Genevestigator; P51774; -.
DR   GermOnline; ENSRNOG00000000640; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; ISS:UniProtKB.
DR   GO; GO:0071837; F:HMG box domain binding; IPI:UniProtKB.
DR   GO; GO:0044212; F:transcription regulatory region DNA binding; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0007611; P:learning or memory; IEP:RGD.
DR   GO; GO:0006611; P:protein export from nucleus; ISS:UniProtKB.
DR   GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IEP:RGD.
DR   GO; GO:0032868; P:response to insulin stimulus; IMP:RGD.
DR   InterPro; IPR021849; DUF3446.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Gene3D; G3DSA:3.30.160.60; Znf_C2H2/integrase_DNA-bd; 3.
DR   Pfam; PF11928; DUF3446; 1.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
DR   HOGENOMDNA; RAT20.PE613; -.
KW   ENSRNOG00000000640820036002503210000011;
KW   Egr2; EGR2_RAT; A4PCC9_RAT; Q9QYG4_RAT; AB032419; AB032420; AB264614;
KW   U78102;
KW   Activator; Alternative splicing; Complete proteome; DNA-binding;
KW   Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
SQ   SEQUENCE   470 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MMTAKAVDKI PVTLSGFMHQ LPDSLYPVED LAAPSVTIFP NGELGGPFDQ MNGVAGDGMI
     NIDMTGEKRP LDLPYPSSFA PISAPRNQTF TYMGKFSIDP QYPGASCYPE GIINIVSAGI
     LQGVTPPAST TASSSVTSAS PNPLATGPLG VCTMSQTQPE LDHLYSPPPP PPPYSGCTGD
     LYQDPSAFLS PPPTTSTSSL AYQPPPSYPS PKPAMDPGLI PMIPDYPGFF PSPCQRDPHG
     AAGPDRKPFP CPLDSLRVPP PLTPLSTIRN FTLGGPSAGV TGPGASGGGE GPRLPGSGSA
     AVTATPYNPH HLPLRPILRP RKYPNRPSKT PVHERPYPCP AEGCDRRFSR SDELTRHIRI
     HTGHKPFQCR ICMRNFSRSD HLTTHIRTHT GEKPFACDYC GRKFARSDER KRHTKIHLRQ
     KERKSSAPSS SASAQSSASG PGGSQAGGSL CGNSAIGGPL ASCTSRTRTP
//

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