(data stored in ACNUC28527 zone)

HOGENOM: RAT20_PE668

ID   RAT20_PE668                          STANDARD;      PRT;   104 AA.
AC   RAT20_PE668; P61459; P70519; P80095; Q9D930;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pterin-4-alpha-carbinolamine dehydratase; Short=PHS;
DE   EC=4.2.1 96;AltName: Full=4-alpha-hydroxy-tetrahydropterin
DE   dehydratase;AltName: Full=Dimerization cofactor of hepatocyte nuclear
DE   factor 1-alpha; Short=DCoH; Short=Dimerization cofactor of HNF1;AltName:
DE   Full=Phenylalanine hydroxylase-stimulating protein;AltName: Full=Pterin
DE   carbinolamine dehydratase; Short=PCD; (RAT20.PE668).
GN   Name=Pcbd1; Synonyms=Dcoh, Pcbd;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT20.PE668.
CC       Rattus norvegicus chromosome 20 RGSC3.4  sequence 1..55268282
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PHS_RAT
CC   -!- FUNCTION: Involved in tetrahydrobiopterin biosynthesis. Seems to
CC       both prevent the formation of 7-pterins and accelerate the
CC       formation of quinonoid-BH2. Coactivator for HNF1A-dependent
CC       transcription. Regulates the dimerization of homeodomain protein
CC       HNF1A and enhances its transcriptional activity.
CC   -!- CATALYTIC ACTIVITY: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-
CC       5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-
CC       dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O.
CC   -!- SUBUNIT: Homotetramer and homodimer. Heterotetramer with HNF1A;
CC       formed by a dimer of dimers.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic and/or
CC       nuclear.
CC   -!- SIMILARITY: Belongs to the pterin-4-alpha-carbinolamine
CC       dehydratase family.
CC   -!- GENE_FAMILY: HOG000007680 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000000566;ENSRNOT00000000687;ENSRNOP00000000687.
DR   EMBL; AJ005542; - ;
DR   EMBL; L04537; - ;
DR   EMBL; M83740; - ;
DR   UniProtKB/Swiss-Prot; P61459; P70519; P80095; Q9D930; -.
DR   EMBL; M83740; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AJ005542; CAA06587.1; -; Genomic_DNA.
DR   EMBL; L04537; AAA40609.1; -; mRNA.
DR   IPI; IPI00193854; -.
DR   PIR; A47189; A47189.
DR   RefSeq; NP_001007602.1; NM_001007601.1.
DR   UniGene; Rn.81180; -.
DR   PDB; 1DCH; X-ray; 3.00 A; A/B/C/D/E/F/G/H=2-103.
DR   PDB; 1DCO; X-ray; 2.30 A; A/B/C/D/E/F/G/H=1-104.
DR   PDB; 1DCP; X-ray; 2.30 A; A/B/C/D/E/F/G/H=1-104.
DR   PDB; 1F93; X-ray; 2.60 A; A/B/C/D=1-104.
DR   PDB; 3HXA; X-ray; 1.80 A; A/B/C/D/E/F/G/H=1-104.
DR   PDBsum; 1DCH; -.
DR   PDBsum; 1DCO; -.
DR   PDBsum; 1DCP; -.
DR   PDBsum; 1F93; -.
DR   PDBsum; 3HXA; -.
DR   ProteinModelPortal; P61459; -.
DR   SMR; P61459; 6-104.
DR   STRING; P61459; -.
DR   PRIDE; P61459; -.
DR   Ensembl; ENSRNOT00000000687; ENSRNOP00000000687; ENSRNOG00000000566.
DR   GeneID; 29700; -.
DR   KEGG; rno:29700; -.
DR   UCSC; NM_001007601; rat.
DR   CTD; 5092; -.
DR   RGD; 3263; Pcbd1.
DR   eggNOG; maNOG20064; -.
DR   GeneTree; ENSGT00390000007221; -.
DR   InParanoid; P61459; -.
DR   OrthoDB; EOG4QNMXP; -.
DR   PhylomeDB; P61459; -.
DR   NextBio; 610103; -.
DR   ArrayExpress; P61459; -.
DR   Genevestigator; P61459; -.
DR   GermOnline; ENSRNOG00000000566; Rattus norvegicus.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; TAS:ProtInc.
DR   GO; GO:0006558; P:L-phenylalanine metabolic process; TAS:ProtInc.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR001533; Trans/pterin_deHydtase.
DR   Gene3D; G3DSA:3.30.1360.20; Trans_pterinDh; 1.
DR   PANTHER; PTHR12599; Trans_pterinDh; 1.
DR   Pfam; PF01329; Pterin_4a; 1.
DR   SUPFAM; SSF55248; Trans_pterinDh; 1.
DR   HOGENOMDNA; RAT20.PE668; -.
KW   ENSRNOG00000000566820036002503210000011;
KW   Pcbd1; PHS_RAT; AJ005542; L04537; M83740;
KW   3D-structure; Acetylation; Activator; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Lyase; Nucleus; Reference proteome;
KW   Tetrahydrobiopterin biosynthesis; Transcription;
KW   Transcription regulation.
SQ   SEQUENCE   104 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAGKAHRLSA EERDQLLPNL RAVGWNELEG RDAIFKQFHF KDFNRAFGFM TRVALQAEKL
     DHHPEWFNVY NKVHITLSTH ECAGLSERDI NLASFIEQVA VSMT
//

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