(data stored in ACNUC27670 zone)

HOGENOM: RAT2_PE1281

ID   RAT2_PE1281                          STANDARD;      PRT;   89 AA.
AC   RAT2_PE1281; P05964; Q9R2B7;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Protein S100-A6;AltName: Full=Calcyclin;AltName:
DE   Full=Prolactin receptor-associated protein;AltName: Full=S100
DE   calcium-binding protein A6; (RAT2.PE1281).
GN   Name=S100a6; Synonyms=Cacy;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE1281.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:S10A6_RAT
CC   -!- FUNCTION: May function as calcium sensor and contribute to
CC       cellular calcium signaling (Potential). May function by
CC       interacting with other proteins and indirectly play a role in the
CC       reorganization of the actin cytoskeleton and in cell motility.
CC       Binds 2 calcium ions. Calcium binding is cooperative (By
CC       similarity). Interacts with FKBP4 (By similarity).
CC   -!- SUBUNIT: Homodimer; head to tail assembly of 2 subunits. Interacts
CC       with ANXA2 and ANXA11 (via N-terminus). Interacts with SUGT1 and
CC       CACYBP. Interacts with TP53. Interacts with tropomyosin (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Nucleus envelope (By similarity). Cytoplasm
CC       (By similarity). Cell membrane; Peripheral membrane protein;
CC       Cytoplasmic side (By similarity).
CC   -!- MISCELLANEOUS: This protein co-purified with the prolactin
CC       receptor.
CC   -!- SIMILARITY: Belongs to the S-100 family.
CC   -!- SIMILARITY: Contains 2 EF-hand domains.
CC   -!- GENE_FAMILY: HOG000246968 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000011647;ENSRNOT00000015612;ENSRNOP00000015612.
DR   EMBL; AF140232; - ;
DR   EMBL; AJ132717; - ;
DR   EMBL; BC166598; - ;
DR   EMBL; CH473976; - ;
DR   UniProtKB/Swiss-Prot; P05964; Q9R2B7; -.
DR   EMBL; AJ132717; CAB42002.1; -; mRNA.
DR   EMBL; AF140232; AAK28306.1; -; mRNA.
DR   IPI; IPI00204818; -.
DR   PIR; B28363; B28363.
DR   RefSeq; NP_445937.1; NM_053485.2.
DR   UniGene; Rn.3233; -.
DR   ProteinModelPortal; P05964; -.
DR   SMR; P05964; 2-89.
DR   IntAct; P05964; 1.
DR   STRING; P05964; -.
DR   PRIDE; P05964; -.
DR   Ensembl; ENSRNOT00000015612; ENSRNOP00000015612; ENSRNOG00000011647.
DR   GeneID; 85247; -.
DR   KEGG; rno:85247; -.
DR   UCSC; NM_053485; rat.
DR   CTD; 6277; -.
DR   RGD; 620264; S100a6.
DR   eggNOG; maNOG21124; -.
DR   GeneTree; ENSGT00600000084162; -.
DR   InParanoid; P05964; -.
DR   OMA; VVNFQEY; -.
DR   OrthoDB; EOG4MSD0W; -.
DR   PhylomeDB; P05964; -.
DR   NextBio; 617322; -.
DR   ArrayExpress; P05964; -.
DR   Genevestigator; P05964; -.
DR   GermOnline; ENSRNOG00000011647; Rattus norvegicus.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0031234; C:extrinsic to internal side of plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005635; C:nuclear envelope; IEA:UniProtKB-SubCell.
DR   GO; GO:0005509; F:calcium ion binding; ISS:UniProtKB.
DR   GO; GO:0015075; F:ion transmembrane transporter activity; IDA:RGD.
DR   InterPro; IPR011992; EF-hand-like_dom.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR018249; EF_HAND_2.
DR   InterPro; IPR001751; S100/CaBP-9k_CS.
DR   InterPro; IPR013787; S100_Ca-bd_sub.
DR   Gene3D; G3DSA:1.10.238.10; EF-Hand_type; 1.
DR   Pfam; PF01023; S_100; 1.
DR   PROSITE; PS00018; EF_HAND_1; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS00303; S100_CABP; 1.
DR   HOGENOMDNA; RAT2.PE1281; -.
KW   ENSRNOG00000011647820036002503210000011;
KW   S100a6; S10A6_RAT; B2GVB1_RAT; AF140232; AJ132717; BC166598; CH473976;
KW   Acetylation; Calcium; Cell membrane; Complete proteome; Cytoplasm;
KW   Direct protein sequencing; Membrane; Metal-binding; Nucleus;
KW   Reference proteome; Repeat.
SQ   SEQUENCE   89 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MACPLDQAIG LLVAIFHKYS GKEGDKHTLS KKELKELIQK ELTIGAKLQD AEIARLMDDL
     DRNKDQEVNF QEYVAFLGAL ALIYNEALK
//

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