(data stored in ACNUC30567 zone)

HOGENOM: RAT2_PE1554

ID   RAT2_PE1554                          STANDARD;      PRT;   747 AA.
AC   RAT2_PE1554; P10759; P78501; Q6LDJ4;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AMP deaminase 1; EC=3.5.4 6;AltName: Full=AMP deaminase
DE   isoform M;AltName: Full=Myoadenylate deaminase; (RAT2.PE1554).
GN   Name=Ampd1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE1554.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AMPD1_RAT
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: AMP + H(2)O = IMP + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway;
CC       IMP from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- TISSUE SPECIFICITY: Three isoforms are present in mammals: AMP
CC       deaminase 1 is the predominant form in skeletal muscle; AMP
CC       deaminase 2 predominates in smooth muscle, non-muscle tissue,
CC       embryonic muscle and undifferentiated myoblasts; AMP deaminase 3
CC       is found in erythrocytes.
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
CC   -!- GENE_FAMILY: HOG000092200 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000018656;ENSRNOT00000025248;ENSRNOP00000025248.
DR   EMBL; J02811; - ;
DR   EMBL; M58688; - ;
DR   UniProtKB/Swiss-Prot; P10759; P78501; Q6LDJ4; -.
DR   EMBL; J02811; AAB54086.1; -; mRNA.
DR   EMBL; M58688; AAA40726.1; -; mRNA.
DR   IPI; IPI00193319; -.
DR   PIR; A27366; A27366.
DR   RefSeq; NP_620231.1; NM_138876.1.
DR   UniGene; Rn.9794; -.
DR   ProteinModelPortal; P10759; -.
DR   STRING; P10759; -.
DR   PRIDE; P10759; -.
DR   Ensembl; ENSRNOT00000025248; ENSRNOP00000025248; ENSRNOG00000018656.
DR   GeneID; 25028; -.
DR   KEGG; rno:25028; -.
DR   UCSC; NM_138876; rat.
DR   CTD; 270; -.
DR   RGD; 2109; Ampd1.
DR   eggNOG; maNOG06305; -.
DR   GeneTree; ENSGT00390000008190; -.
DR   InParanoid; P10759; -.
DR   OMA; FRSKNFL; -.
DR   OrthoDB; EOG402WRH; -.
DR   PhylomeDB; P10759; -.
DR   NextBio; 605167; -.
DR   ArrayExpress; P10759; -.
DR   Genevestigator; P10759; -.
DR   GermOnline; ENSRNOG00000018656; Rattus norvegicus.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0032036; F:myosin heavy chain binding; IDA:RGD.
DR   GO; GO:0006144; P:purine base metabolic process; IEA:InterPro.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0010033; P:response to organic substance; IDA:RGD.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006329; AMP_deaminase.
DR   InterPro; IPR016297; AMP_deaminase_met.
DR   Pfam; PF00962; A_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   TIGRFAMs; TIGR01429; AMP_deaminase; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
DR   HOGENOMDNA; RAT2.PE1554; -.
KW   ENSRNOG00000018656820036002503210000011;
KW   Ampd1; AMPD1_RAT; J02811; M58688;
KW   Complete proteome; Direct protein sequencing; Hydrolase;
KW   Metal-binding; Nucleotide metabolism; Reference proteome; Zinc.
SQ   SEQUENCE   747 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MPLFKLTGQG KQIDDAMRSF AEKVFASEVK DEGGRHEISP FDVDEICPIS LREMQAHIFH
     MENLSMSMDG RRKRRFQGRK TVNLSIPQSE TSSTKLSHIE EFISSSPTYE SVPDFQRVQI
     TGDYASGVTV EDFEVVCKGL YRALCIREKY MQKSFQRFPK TPSKYLRNID GEALVAIESF
     YPVFTPPPKK GEDPFRREDL PANLGYHLKM KGGVIYIYPD EAAASRDEPK PYPYPNLDDF
     LDDMNFLLAL IAQGPVKTYT HRRLKFLSSK FQVHQMLNEM DELKELKNNP HRDFYNCRKV
     DTHIHAAACM NQKHLLRFIK KSYHIDADRV VYSTKEKNLT LKELFAQLNM HPYDLTVDSL
     DVHAGRQTFQ RFDKFNDKYN PVGASELRDL YLKTDNYING EYFATIIKEV GADLVDAKYQ
     HAEPRLSIYG RSPDEWSKLS SWFVGNRIYC PNMTWMIQVP RIYDVFRSKN FLPHFGKMLE
     NIFLPVFEAT INPQTHPDLS VFLKHITGFD SVDDESKHSG HMFSSKSPKP EEWTMENNPS
     YTYYAYYMYA NIMVLNCLRK ERGMNTFLFR PHCGEAGALT HLMTAFMIAD NISHGLNLKK
     SPVLQYLFFL AQIPIAMSPL SNNSLFLEYA KNPFLDFLQK GLMISLSTDD PMQFHFTKEP
     LMEEYAIAAQ VFKLSTCDMC EVARNSVLQC GISHEEKAKF LGNNYLEEGP VGNDIRRTNV
     AQIRMAYRYE TWCYELNLIA EGLKSTE
//

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