(data stored in ACNUC7421 zone)

HOGENOM: RAT2_PE1604

ID   RAT2_PE1604                          STANDARD;      PRT;   184 AA.
AC   RAT2_PE1604; P62836; P10113;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ras-related protein Rap-1A;AltName: Full=Ras-related
DE   protein Krev-1;Flags: Precursor; (RAT2.PE1604).
GN   Name=Rap1a; Synonyms=Krev1;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE1604.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RAP1A_RAT
CC   -!- FUNCTION: Induces morphological reversion of a cell line
CC       transformed by a Ras oncogene. Counteracts the mitogenic function
CC       of Ras, at least partly because it can interact with Ras GAPs and
CC       RAF in a competitive manner (By similarity).
CC   -!- ENZYME REGULATION: Activated by guanine nucleotide-exchange
CC       factors (GEF) EPAC and EPAC2 in a cAMP-dependent manner, and GFR
CC       (By similarity).
CC   -!- SUBUNIT: In its GTP-bound form interacts with PLCE1 and RADIL.
CC       Interacts with SGSM1, SGSM2 and SGSM3 (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor (By similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC   -!- GENE_FAMILY: HOG000233973 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000032463;ENSRNOT00000047836;ENSRNOP00000040409.
DR   EMBL; BC083813; - ;
DR   EMBL; D88312; - ;
DR   UniProtKB/Swiss-Prot; P62836; P10113; -.
DR   EMBL; BC083813; AAH83813.1; -; mRNA.
DR   IPI; IPI00187747; -.
DR   PIR; A61216; A61216.
DR   RefSeq; NP_001005765.1; NM_001005765.1.
DR   UniGene; Rn.106321; -.
DR   ProteinModelPortal; P62836; -.
DR   SMR; P62836; 1-167.
DR   STRING; P62836; -.
DR   PhosphoSite; P62836; -.
DR   PRIDE; P62836; -.
DR   Ensembl; ENSRNOT00000047836; ENSRNOP00000040409; ENSRNOG00000032463.
DR   GeneID; 295347; -.
DR   KEGG; rno:295347; -.
DR   UCSC; NM_001005765; rat.
DR   CTD; 5906; -.
DR   RGD; 1359694; Rap1a.
DR   GeneTree; ENSGT00560000076632; -.
DR   InParanoid; P62836; -.
DR   OMA; DSIGTHE; -.
DR   OrthoDB; EOG45MN6H; -.
DR   PhylomeDB; P62836; -.
DR   Reactome; REACT_96194; Signalling by NGF.
DR   NextBio; 639425; -.
DR   ArrayExpress; P62836; -.
DR   Genevestigator; P62836; -.
DR   GermOnline; ENSRNOG00000032463; Rattus norvegicus.
DR   GO; GO:0005829; C:cytosol; EXP:Reactome.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   HOGENOMDNA; RAT2.PE1604; -.
KW   ENSRNOG00000032463820036002503210000011;
KW   Rap1a; RAP1A_RAT; O08813_RAT; BC083813; D88312;
KW   Cell membrane; Complete proteome; GTP-binding; Lipoprotein; Membrane;
KW   Methylation; Nucleotide-binding; Prenylation; Reference proteome;
KW   Tumor suppressor.
SQ   SEQUENCE   184 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MREYKLVVLG SGGVGKSALT VQFVQGIFVE KYDPTIEDSY RKQVEVDCQQ CMLEILDTAG
     TEQFTAMRDL YMKNGQGFAL VYSITAQSTF NDLQDLREQI LRVKDTEDVP MILVGNKCDL
     EDERVVGKEQ GQNLARQWCN CAFLESSAKS KINVNEIFYD LVRQINRKTP VEKKKPKKKS
     CLLL
//

If you have problems or comments...

PBIL Back to PBIL home page