(data stored in ACNUC30567 zone)

HOGENOM: RAT2_PE1660

ID   RAT2_PE1660                          STANDARD;      PRT;   824 AA.
AC   RAT2_PE1660; Q02356; B2GUT6;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=AMP deaminase 2; EC=3.5.4 6;AltName: Full=AMP deaminase
DE   isoform L; (RAT2.PE1660).
GN   Name=Ampd2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE1660.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:AMPD2_RAT
CC   -!- FUNCTION: AMP deaminase plays a critical role in energy
CC       metabolism.
CC   -!- CATALYTIC ACTIVITY: AMP + H(2)O = IMP + NH(3).
CC   -!- COFACTOR: Binds 1 zinc ion per subunit (By similarity).
CC   -!- PATHWAY: Purine metabolism; IMP biosynthesis via salvage pathway;
CC       IMP from AMP: step 1/1.
CC   -!- SUBUNIT: Homotetramer.
CC   -!- TISSUE SPECIFICITY: Three isoforms are present in mammals: AMP
CC       deaminase 1 is the predominant form in skeletal muscle; AMP
CC       deaminase 2 predominates in smooth muscle, non-muscle tissue,
CC       embryonic muscle and undifferentiated myoblasts; AMP deaminase 3
CC       is found in erythrocytes.
CC   -!- SIMILARITY: Belongs to the adenosine and AMP deaminases family.
CC   -!- GENE_FAMILY: HOG000092200 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000019240;ENSRNOT00000026051;ENSRNOP00000026051.
DR   EMBL; BC166402; - ;
DR   EMBL; M38126; - ;
DR   UniProtKB/Swiss-Prot; Q02356; B2GUT6; -.
DR   EMBL; BC166402; AAI66402.1; -; mRNA.
DR   EMBL; M38126; AAA40728.1; -; Genomic_DNA.
DR   IPI; IPI00554244; -.
DR   PIR; A37056; A37056.
DR   RefSeq; NP_001095151.1; NM_001101681.2.
DR   UniGene; Rn.104557; -.
DR   ProteinModelPortal; Q02356; -.
DR   SMR; Q02356; 160-807.
DR   STRING; Q02356; -.
DR   PhosphoSite; Q02356; -.
DR   Ensembl; ENSRNOT00000026051; ENSRNOP00000026051; ENSRNOG00000019240.
DR   GeneID; 362015; -.
DR   KEGG; rno:362015; -.
DR   CTD; 271; -.
DR   RGD; 2110; Ampd2.
DR   eggNOG; maNOG15902; -.
DR   GeneTree; ENSGT00390000008190; -.
DR   InParanoid; Q02356; -.
DR   OrthoDB; EOG41JZBP; -.
DR   PhylomeDB; Q02356; -.
DR   ArrayExpress; Q02356; -.
DR   Genevestigator; Q02356; -.
DR   GermOnline; ENSRNOG00000019240; Rattus norvegicus.
DR   GO; GO:0003876; F:AMP deaminase activity; IEA:EC.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006144; P:purine base metabolic process; IEA:InterPro.
DR   GO; GO:0009168; P:purine ribonucleoside monophosphate biosynthetic process; IEA:InterPro.
DR   InterPro; IPR006650; A/AMP_deam_AS.
DR   InterPro; IPR001365; A/AMP_deaminase.
DR   InterPro; IPR006329; AMP_deaminase.
DR   InterPro; IPR016297; AMP_deaminase_met.
DR   Pfam; PF00962; A_deaminase; 1.
DR   PIRSF; PIRSF001251; AMP_deaminase_met; 1.
DR   TIGRFAMs; TIGR01429; AMP_deaminase; 1.
DR   PROSITE; PS00485; A_DEAMINASE; 1.
DR   HOGENOMDNA; RAT2.PE1660; -.
KW   ENSRNOG00000019240820036002503210000011;
KW   Ampd2; AMPD2_RAT; BC166402; M38126;
KW   Acetylation; Complete proteome; Hydrolase; Metal-binding;
KW   Nucleotide metabolism; Phosphoprotein; Reference proteome; Zinc.
SQ   SEQUENCE   824 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MASYPGPGKS KAKYPFKKRA SLQASAAAPE ARSGLGASPL QSARSLPGTA PCLKHFPLDL
     RTSMDGKCKE IAEELFSRSL AESELRSAPY EFPEESPIEQ LEERRQRLER QISQDVKLEP
     DILLRAKQDF LKTDSDSDLQ LYKEQGEGQG DRGLWERDVV LEREFQRVII SGEEKCGVPF
     TDLLDAAKSV VRALFIREKY MALSLQSFCP TTRRYLQQLA EKPLETRTYE QSPDTPVSAD
     APVHPPALEQ HPYEHCEPST MPGDLGLGLR MVRGVVHVYT RRDPDEHCPE VELPYPDLQE
     FVADVNVLMA LIINGPIKSF CYRRLQYLSS KFQMHVLLNE MKELAAQKKV PHRDFYNIRK
     VDTHIHASSC MNQKHLLRFI KRAMKRHLEE IVHVEQGREQ TLREVFESMN LTAYDLSVDT
     LDVHADRNTF HRFDKFNAKY NPIGESVLRE IFIKTDNKIS GKYFAHIIKE VMSDLEESKY
     QNAELRLSIY GRSRDEWDKL ARWAVNHRVH SPNVRWLVQV PRLFDVYRTK GQLANFQEML
     ENIFLPLFEA TVHPASHPEL HLFLEHVDGF DSVDDESKPE NHVFNLESPL PEAWVEEDNP
     PYAYYLYYTF ANMAMLNHLR RQRGFHTFVL RPHCGEAGPI HHLVSAFMLA ENISHGLLLR
     KAPVLQYLYY LAQIGIAMSP LSNNSLFLSY HRNPLPEYLS RGLMVSLSTD DPLQFHFTKE
     PLMEEYSIAT QVWKLSSCDM CELARNSVLM SGFSHKVKSH WLGPNYTKEG PEGNDIRRTN
     VPDIRVGYRY ETLCQELALI TQAVQSEMLE TIPEEVGIVM SPGP
//

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