(data stored in ACNUC13365 zone)

HOGENOM: RAT2_PE1695

ID   RAT2_PE1695                          STANDARD;      PRT;   544 AA.
AC   RAT2_PE1695; Q9WU61; Q66HQ5; Q8VIE8; Q8VIE9; Q8VIF0; Q8VIF1;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Chloride channel CLIC-like protein 1;AltName:
DE   Full=Mid-1-related chloride channel protein 1;Flags: Precursor;
DE   (RAT2.PE1695).
GN   Name=Clcc1; Synonyms=Mclc;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE1695.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:CLCC1_RAT
CC   -!- FUNCTION: Seems to act as a chloride ion channel.
CC   -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein
CC       (Potential). Endoplasmic reticulum. Golgi apparatus. Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=5;
CC       Name=1; Synonyms=rMCLC-1;
CC         IsoId=Q9WU61-1; Sequence=Displayed;
CC       Name=2; Synonyms=rMCLC-2;
CC         IsoId=Q9WU61-2; Sequence=VSP_027350;
CC       Name=3; Synonyms=rMCLC-3;
CC         IsoId=Q9WU61-3; Sequence=VSP_027352, VSP_027353;
CC       Name=4; Synonyms=rMCLC-4;
CC         IsoId=Q9WU61-4; Sequence=VSP_027350, VSP_027352, VSP_027353;
CC       Name=5; Synonyms=rMCLC-5;
CC         IsoId=Q9WU61-5; Sequence=VSP_027351, VSP_027354;
CC   -!- TISSUE SPECIFICITY: Expressed in testis (spermatocytes), liver and
CC       lung (at protein level). Expressed in spleen, liver, testis,
CC       kidney, heart, brain and lung.
CC   -!- SIMILARITY: Belongs to the chloride channel MCLC family.
CC   -!- GENE_FAMILY: HOG000231351 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000020360;ENSRNOT00000051701;ENSRNOP00000042185.
DR   EMBL; AB052919; - ;
DR   EMBL; AB052920; - ;
DR   EMBL; AB052921; - ;
DR   EMBL; AB052922; - ;
DR   EMBL; AB052923; - ;
DR   EMBL; AF117330; - ;
DR   EMBL; BC081736; - ;
DR   UniProtKB/Swiss-Prot; Q9WU61; Q66HQ5; Q8VIE8; Q8VIE9; Q8VIF0; Q8VIF1; -.
DR   EMBL; AB052919; BAB79264.1; -; mRNA.
DR   EMBL; AB052920; BAB79265.1; -; mRNA.
DR   EMBL; AB052921; BAB79266.1; -; mRNA.
DR   EMBL; AB052922; BAB59019.1; -; mRNA.
DR   EMBL; AB052923; BAB79267.1; -; mRNA.
DR   EMBL; AF117330; AAD26207.1; -; mRNA.
DR   EMBL; BC081736; AAH81736.1; -; mRNA.
DR   IPI; IPI00203434; -.
DR   IPI; IPI00326756; -.
DR   IPI; IPI00858336; -.
DR   IPI; IPI00858368; -.
DR   IPI; IPI00858436; -.
DR   RefSeq; NP_596905.1; NM_133414.1.
DR   UniGene; Rn.26586; -.
DR   PhosphoSite; Q9WU61; -.
DR   PRIDE; Q9WU61; -.
DR   GeneID; 170927; -.
DR   KEGG; rno:170927; -.
DR   CTD; 23155; -.
DR   RGD; 708359; Clcc1.
DR   eggNOG; roNOG09071; -.
DR   GeneTree; ENSGT00390000016611; -.
DR   InParanoid; Q9WU61; -.
DR   OrthoDB; EOG4CC41V; -.
DR   NextBio; 621443; -.
DR   ArrayExpress; Q9WU61; -.
DR   Genevestigator; Q9WU61; -.
DR   GO; GO:0005783; C:endoplasmic reticulum; IMP:HGNC.
DR   GO; GO:0005794; C:Golgi apparatus; IMP:HGNC.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005792; C:microsome; IMP:HGNC.
DR   GO; GO:0005634; C:nucleus; IDA:HGNC.
DR   GO; GO:0005254; F:chloride channel activity; IMP:HGNC.
DR   InterPro; IPR009231; Chloride_chnl_CLIC-like.
DR   Pfam; PF05934; MCLC; 1.
DR   HOGENOMDNA; RAT2.PE1695; -.
KW   ENSRNOG00000020360820036002503210000011;
KW   Clcc1; CLCC1_RAT; AB052919; AB052920; AB052921; AB052922; AB052923;
KW   BC081736;
KW   Alternative splicing; Complete proteome; Endoplasmic reticulum;
KW   Golgi apparatus; Membrane; Nucleus; Phosphoprotein;
KW   Reference proteome; Signal; Transmembrane; Transmembrane helix.
SQ   SEQUENCE   544 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MLRMLCSLLL CGCLLLITGY AHDDDWIDPT DMLNYDAASG TMRKSQAKYG TSEKKEVNPD
     LSDAQELSDC LQRLDSLTHK VDDCEKKKMK DYESQSNPVF RRYLNKILIE AGKLGLPDED
     RVDVRYDAEI LLTRQTLLEI QKFLSGEEWK PGALDDALSD ILTNFKSHDS EAWKWQFEDY
     FGVDPYNVFM VLLCLLCIVA LVATELWTYV RWHTQLKRVC IISFLVSLGW NWIYLYKVAF
     AQHQANVAKM APLNDVCAKK MDWTENLWEW FRISWTYKDD PCQKYYELLI VNPIWLVPPT
     KALAVTFTNF VTEPLKYIGK GTGEFIKALM KEIPVLLQIP VLVILALAVL GFCYGAGQSV
     PMLRHFRGPE REPPRALEPD DRRRQKELDY RFHGGAGDAD FSYRGPAGSI EQGPYDKMHA
     CERDVLRQRQ VNMRFPSGNK SPEVLRAFDL PDTEAQEHPE VVPSHKPSIV NTSLKETSEL
     PRESTLAECS QCAKDGSGQV PSTAESSPIV EKAQLKTDSE CRPHSTEAAA AAARGTDPVS
     SPCG
//

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