(data stored in ACNUC4482 zone)

HOGENOM: RAT2_PE316

ID   RAT2_PE316                           STANDARD;      PRT;   1159 AA.
AC   RAT2_PE316; Q924S3;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   Flags: Fragments;
DE   SubName: Full=Alpha 2 integrin;Flags: Fragment; (RAT2.PE316).
GN   Name=Itga2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE316.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:Q924S3_RAT
CC   -!- SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane
CC       protein (By similarity).
CC   -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC   -!- GENE_FAMILY: HOG000059610 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000011877;ENSRNOT00000015940;ENSRNOP00000015940.
DR   EMBL; AB067445; - ;
DR   UniProtKB/Swiss-Prot; Q924S3; -.
DR   EMBL; AB067445; BAB62267.1; -; mRNA.
DR   IPI; IPI00367939; -.
DR   UniGene; Rn.83597; -.
DR   ProteinModelPortal; Q924S3; -.
DR   STRING; Q924S3; -.
DR   RGD; 621632; Itga2.
DR   eggNOG; maNOG13795; -.
DR   GeneTree; ENSGT00600000084333; -.
DR   InParanoid; Q924S3; -.
DR   OrthoDB; EOG45B1DV; -.
DR   Genevestigator; Q924S3; -.
DR   GO; GO:0043679; C:axon terminus; IDA:RGD.
DR   GO; GO:0009279; C:cell outer membrane; IDA:RGD.
DR   GO; GO:0009986; C:cell surface; IDA:RGD.
DR   GO; GO:0005615; C:extracellular space; TAS:RGD.
DR   GO; GO:0005925; C:focal adhesion; IDA:RGD.
DR   GO; GO:0008305; C:integrin complex; TAS:RGD.
DR   GO; GO:0005634; C:nucleus; IDA:RGD.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IDA:RGD.
DR   GO; GO:0050839; F:cell adhesion molecule binding; TAS:RGD.
DR   GO; GO:0005518; F:collagen binding; TAS:RGD.
DR   GO; GO:0005178; F:integrin binding; IMP:RGD.
DR   GO; GO:0043236; F:laminin binding; IMP:RGD.
DR   GO; GO:0046982; F:protein heterodimerization activity; IDA:RGD.
DR   GO; GO:0004872; F:receptor activity; IEA:UniProtKB-KW.
DR   GO; GO:0007155; P:cell adhesion; TAS:RGD.
DR   GO; GO:0008283; P:cell proliferation; IEP:RGD.
DR   GO; GO:0006928; P:cellular component movement; IEP:RGD.
DR   GO; GO:0032870; P:cellular response to hormone stimulus; IEP:RGD.
DR   GO; GO:0050966; P:detection of mechanical stimulus involved in sensory perception of pain; IMP:RGD.
DR   GO; GO:0045184; P:establishment of protein localization; IDA:RGD.
DR   GO; GO:0070365; P:hepatocyte differentiation; IEP:RGD.
DR   GO; GO:0006971; P:hypotonic response; IMP:RGD.
DR   GO; GO:0007229; P:integrin-mediated signaling pathway; TAS:RGD.
DR   GO; GO:0030879; P:mammary gland development; IEP:RGD.
DR   GO; GO:0010694; P:positive regulation of alkaline phosphatase activity; IMP:RGD.
DR   GO; GO:0045785; P:positive regulation of cell adhesion; IMP:RGD.
DR   GO; GO:0031346; P:positive regulation of cell projection organization; IMP:RGD.
DR   GO; GO:0033343; P:positive regulation of collagen binding; IMP:RGD.
DR   GO; GO:0032967; P:positive regulation of collagen biosynthetic process; IMP:RGD.
DR   GO; GO:0043388; P:positive regulation of DNA binding; IMP:RGD.
DR   GO; GO:0010634; P:positive regulation of epithelial cell migration; IMP:RGD.
DR   GO; GO:0050729; P:positive regulation of inflammatory response; IMP:RGD.
DR   GO; GO:0002687; P:positive regulation of leukocyte migration; IMP:RGD.
DR   GO; GO:0060100; P:positive regulation of phagocytosis, engulfment; IMP:RGD.
DR   GO; GO:0050927; P:positive regulation of positive chemotaxis; IMP:RGD.
DR   GO; GO:0014911; P:positive regulation of smooth muscle cell migration; IMP:RGD.
DR   GO; GO:0048661; P:positive regulation of smooth muscle cell proliferation; IMP:RGD.
DR   GO; GO:0045987; P:positive regulation of smooth muscle contraction; IMP:RGD.
DR   GO; GO:0045727; P:positive regulation of translation; IMP:RGD.
DR   GO; GO:0051971; P:positive regulation of transmission of nerve impulse; IMP:RGD.
DR   GO; GO:0014075; P:response to amine stimulus; IEP:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0033591; P:response to L-ascorbic acid; IEP:RGD.
DR   GO; GO:0014850; P:response to muscle activity; IEP:RGD.
DR   GO; GO:0014070; P:response to organic cyclic compound; IEP:RGD.
DR   GO; GO:0051789; P:response to protein stimulus; IEP:RGD.
DR   GO; GO:0043589; P:skin morphogenesis; IMP:RGD.
DR   GO; GO:0001894; P:tissue homeostasis; IMP:RGD.
DR   GO; GO:0042060; P:wound healing; IEP:RGD.
DR   InterPro; IPR013649; Integrin_alpha-2.
DR   InterPro; IPR018184; Integrin_alpha_C_CS.
DR   Pfam; PF00357; Integrin_alpha; 1.
DR   Pfam; PF08441; Integrin_alpha2; 1.
DR   PROSITE; PS00242; INTEGRIN_ALPHA; 1.
DR   HOGENOMDNA; RAT2.PE316; -.
KW   ENSRNOG00000011877820036002503210000011;
KW   Itga2; Q924S3_RAT; AB067445;
KW   Cell adhesion; Integrin; Receptor; Transmembrane.
SQ   SEQUENCE   1159 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     GLLSCLAYNV GLPGAKIFSG SSSEQFGYSV QQLTTPQGNW LLVGSPWSGF PDNRMGDVYK
     CPVDLPTATC EKLNLQNSAS ISNVTEIKTN MSLGLTLTRN PGTGGFLTCG PLWAHQCGNQ
     YYATGICSDV SPDFQSLTSF SPAVQACPSL VDVVVVCDES NSIYPWEAVK NFLEKFVQGL
     DIGPKKTQVA LIQYANDPRV VFNLTTYKNK EDMVQATSET RQYGGDLTNT FKAIQFARDI
     AYLPESGGRP GATKVMVVVT DGESHDGSKL QTVIQQCNDD EILRFGIAVL GYLNRNALDT
     KNLIKEIKAI ASTPTERYFF NVADEAALLE KAGTLGEHIF SIEGTVQGGD NFQMEMAQVG
     FSADYSPQND ILMLGAVGAF DWSGTVVQET SYEHLIFPKQ AFDQVLQDRN HSSFLGYSVA
     AISTENGVHF VAGAPRANYT GQIVLYSVNK HGNVTVIQSH RGDQIGSYFG SVLCSVDVDK
     DTITDVLLVG APMYMNDLKK EEGKVYLFTI TKGVLNQHQF LEGPEGTGNA RFGSAIAALS
     DINMDGFNDV IVGSPVENEN SGAVYIYNGH QGTIRTKYSQ KILGSDGAFK SHLQFFGRSL
     DGYGDLNGDS ITDVSIGALG QVVQLWSQSV ADVATEASFT PDKIILLNKE AKITLKLCFR
     AKFRPPGQNH QVAILFNMTL DADQYSSRVT SRGIFRENSE RFLQKTMVVS EVENCSEYHI
     SIQKPSDVVN PLDLRVDISL EKPGTSPALE AYSETVKVFS IPFYKECGSD GICISDLILD
     VRQLPALRNQ PFIVSNQNKR LTFSVTLKNR GESAYNTAVL AEFSENLFFA SFSMPVDGTE
     VTCQIGSSQK SVTCDVGYPA LKSEQQVTFT INFDFNLQNL QNQAAINFQA FSESQETNKA
     DNSVSLIVPL LYDAELHLTR STNINFYEIS SDENAPSVIN SVEDIGPEFI FSLKITAGSA
     PVSMASVTIH IPLHTKEKNP LLYLTGIQTD KAGDISCRAE INPLNLPHTA SPVSFKSENF
     RHMKELDCKT TSCSNVSCWL KDLHMKAEYF INVTTRVWNR TFAASTFQTV QLTAAAEIDT
     HNPQLFVIEE NAVTIPLMIM KPTEKAEVPT GVIIGSIIAG ILLLLAMVAG LWKLGFFKRQ
     YKKMGQNPDE TDETTELNS
//

If you have problems or comments...

PBIL Back to PBIL home page