(data stored in ACNUC7421 zone)

HOGENOM: RAT2_PE923

ID   RAT2_PE923                           STANDARD;      PRT;   183 AA.
AC   RAT2_PE923; P61227; P17964; Q96EG5; Q9CXG0;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Ras-related protein Rap-2b;Flags: Precursor; (RAT2.PE923).
GN   Name=Rap2b;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT2.PE923.
CC       Rattus norvegicus chromosome 2 RGSC3.4  sequence 1..258207540
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:RAP2B_RAT
CC   -!- FUNCTION: Small GTP-binding protein which cycles between a GDP-
CC       bound inactive and a GTP-bound active form. Involved in EGFR and
CC       CHRM3 signaling pathways through stimulation of PLCE1. May play a
CC       role in cytoskeletal rearrangements and regulate cell spreading
CC       through activation of the effector TNIK. May regulate membrane
CC       vesiculation in red blood cells (By similarity).
CC   -!- SUBUNIT: Interacts with PLCE1. Interacts with SGSM1, SGSM2 and
CC       SGSM3. The GTP-bound form of RAP2B interacts with RUNDC3A (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Recycling endosome membrane; Lipid-anchor;
CC       Cytoplasmic side. Note=Associated with red blood cells-released
CC       vesicles (By similarity).
CC   -!- DOMAIN: The effector domain mediates the interaction with RUNDC3A
CC       (By similarity).
CC   -!- PTM: Palmitoylated. Palmitoylation is required for association
CC       with recycling endosome membranes and activation of TNIK (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC   -!- GENE_FAMILY: HOG000233973 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000014420;ENSRNOT00000019340;ENSRNOP00000019340.
DR   EMBL; AF386786; - ;
DR   UniProtKB/Swiss-Prot; P61227; P17964; Q96EG5; Q9CXG0; -.
DR   EMBL; AF386786; AAK66772.1; -; mRNA.
DR   IPI; IPI00193000; -.
DR   RefSeq; NP_596901.1; NM_133410.1.
DR   UniGene; Rn.217110; -.
DR   ProteinModelPortal; P61227; -.
DR   SMR; P61227; 1-167.
DR   STRING; P61227; -.
DR   PRIDE; P61227; -.
DR   Ensembl; ENSRNOT00000019340; ENSRNOP00000019340; ENSRNOG00000014420.
DR   GeneID; 170923; -.
DR   KEGG; rno:170923; -.
DR   CTD; 5912; -.
DR   RGD; 620591; Rap2b.
DR   eggNOG; roNOG15845; -.
DR   GeneTree; ENSGT00560000076632; -.
DR   InParanoid; P61227; -.
DR   OMA; SQPNGDD; -.
DR   OrthoDB; EOG4P2Q3G; -.
DR   PhylomeDB; P61227; -.
DR   NextBio; 621427; -.
DR   ArrayExpress; P61227; -.
DR   Genevestigator; P61227; -.
DR   GermOnline; ENSRNOG00000014420; Rattus norvegicus.
DR   GO; GO:0055038; C:recycling endosome membrane; ISS:UniProtKB.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0032486; P:Rap protein signal transduction; ISS:UniProtKB.
DR   GO; GO:0061097; P:regulation of protein tyrosine kinase activity; ISS:UniProtKB.
DR   InterPro; IPR005225; Small_GTP-bd_dom.
DR   InterPro; IPR001806; Small_GTPase.
DR   InterPro; IPR020849; Small_GTPase_Ras.
DR   PANTHER; PTHR24070; PTHR24070; 1.
DR   Pfam; PF00071; Ras; 1.
DR   PRINTS; PR00449; RASTRNSFRMNG.
DR   SMART; SM00173; RAS; 1.
DR   TIGRFAMs; TIGR00231; Small_GTP; 1.
DR   PROSITE; PS51421; RAS; 1.
DR   HOGENOMDNA; RAT2.PE923; -.
KW   ENSRNOG00000014420820036002503210000011;
KW   Rap2b; RAP2B_RAT; AF386786;
KW   Complete proteome; Endosome; GTP-binding; Lipoprotein; Membrane;
KW   Methylation; Nucleotide-binding; Palmitate; Prenylation;
KW   Reference proteome.
SQ   SEQUENCE   183 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MREYKVVVLG SGGVGKSALT VQFVTGSFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG
     TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI IRVKRYERVP MILVGNKVDL
     EGEREVSYGE GKALAEEWSC PFMETSAKNK ASVDELFAEI VRQMNYAAQP NGDEGCCSAC
     VIL
//

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