(data stored in ACNUC29543 zone)

HOGENOM: RAT3_PE1316

ID   RAT3_PE1316                          STANDARD;      PRT;   295 AA.
AC   RAT3_PE1316; Q5XIC8;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;
DE   EC=1.14.11 -;AltName: Full=Alkylated DNA repair protein alkB homolog 3;
DE   (RAT3.PE1316).
GN   Name=Alkbh3; Synonyms=Abh3;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT3.PE1316.
CC       Rattus norvegicus chromosome 3 RGSC3.4  sequence 1..171063335 annotated
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:ALKB3_RAT
CC   -!- FUNCTION: Dioxygenase that repairs alkylated DNA and RNA
CC       containing 1-methyladenine and 3-methylcytosine by oxidative
CC       demethylation. Has a preference for single-stranded substrates.
CC       Requires molecular oxygen, alpha-ketoglutarate and iron (By
CC       similarity).
CC   -!- COFACTOR: Binds 1 Fe(2+) ion per subunit (By similarity).
CC   -!- ENZYME REGULATION: Activated by ascorbate (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity).
CC   -!- SIMILARITY: Belongs to the alkB family.
CC   -!- SIMILARITY: Contains 1 Fe2OG dioxygenase domain.
CC   -!- GENE_FAMILY: HOG000207105 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000021678;ENSRNOT00000030784;ENSRNOP00000030278.
DR   EMBL; BC083756; - ;
DR   UniProtKB/Swiss-Prot; Q5XIC8; -.
DR   EMBL; BC083756; AAH83756.1; -; mRNA.
DR   IPI; IPI00373650; -.
DR   RefSeq; NP_001014202.1; NM_001014180.1.
DR   UniGene; Rn.30490; -.
DR   ProteinModelPortal; Q5XIC8; -.
DR   SMR; Q5XIC8; 70-279.
DR   PRIDE; Q5XIC8; -.
DR   Ensembl; ENSRNOT00000030784; ENSRNOP00000030278; ENSRNOG00000021678.
DR   GeneID; 362169; -.
DR   KEGG; rno:362169; -.
DR   UCSC; NM_001014180; rat.
DR   CTD; 221120; -.
DR   RGD; 1359731; Alkbh3.
DR   eggNOG; roNOG07255; -.
DR   GeneTree; ENSGT00530000063618; -.
DR   InParanoid; Q5XIC8; -.
DR   OrthoDB; EOG41JZCZ; -.
DR   NextBio; 678874; -.
DR   ArrayExpress; Q5XIC8; -.
DR   Genevestigator; Q5XIC8; -.
DR   GermOnline; ENSRNOG00000021678; Rattus norvegicus.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043734; F:DNA-N1-methyladenine dioxygenase activity; ISS:UniProtKB.
DR   GO; GO:0008198; F:ferrous iron binding; ISS:UniProtKB.
DR   GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporDR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0006307; P:DNA dealkylation involved in DNA repair; ISS:UniProtKB.
DR   GO; GO:0035552; P:oxidative single-stranded DNA demethylation; ISS:UniProtKB.
DR   InterPro; IPR005123; Oxoglutarate/Fe-dep_oxygenase.
DR   Pfam; PF03171; 2OG-FeII_Oxy; 1.
DR   PROSITE; PS51471; FE2OG_OXY; 1.
DR   HOGENOMDNA; RAT3.PE1316; -.
KW   ENSRNOG00000021678820036002503210000011;
KW   Alkbh3; ALKB3_RAT; BC083756;
KW   Complete proteome; Cytoplasm; Dioxygenase; DNA damage; DNA repair;
KW   Iron; Metal-binding; Nucleus; Oxidoreductase; Reference proteome.
SQ   SEQUENCE   295 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MGDKRQRARV QGAWATPTKS QSAARPATPA RSRPSQTPGP SWRSKEQQQC DRRFVFKEPQ
     LVVRAAPEPR VIDREGVYEI SLSPTGVSRV CLYPGFVDLK EADWILERLC QDVPWKQRMG
     IREDITYPQP RLTAWYGELP YTYSRVTMEP NPHWLPVLWT LKSRIEENTG HTFNSLLCNF
     YRDEKDSVDW HSDDEPSLGS CPVIASLSFG ATRTFEMRKK PPPEENGDYT YVERVKIPLD
     HGTLLIMEGA TQADWQHRVP KEYHSRERRV NLTFRTVYPD PRGAPGDTSA ELPLR
//

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