(data stored in ACNUC26462 zone)

HOGENOM: RAT3_PE2171

ID   RAT3_PE2171                          STANDARD;      PRT;   610 AA.
AC   RAT3_PE2171; P20689;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Myosin light chain kinase 2, skeletal/cardiac muscle;
DE   Short=MLCK2; EC=2.7.11 18; (RAT3.PE2171).
GN   Name=Mylk2;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT3.PE2171.
CC       Rattus norvegicus chromosome 3 RGSC3.4  sequence 1..171063335 annotated
CC       by Ensembl
CC   -!- ANNOTATIONS ORIGIN:MYLK2_RAT
CC   -!- FUNCTION: Implicated in the level of global muscle contraction and
CC       cardiac function (By similarity). Phosphorylates a specific serine
CC       in the N-terminus of a myosin light chain.
CC   -!- CATALYTIC ACTIVITY: ATP + [myosin light-chain] = ADP + [myosin
CC       light-chain] phosphate.
CC   -!- SUBUNIT: May interact with centrin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Note=Colocalizes
CC       with phosphorylated myosin light chain (RLCP) at filaments of the
CC       myofibrils (By similarity).
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK
CC       Ser/Thr protein kinase family.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC   -!- GENE_FAMILY: HOG000233016 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000008235;ENSRNOT00000011255;ENSRNOP00000011255.
DR   EMBL; J03886; - ;
DR   UniProtKB/Swiss-Prot; P20689; -.
DR   EMBL; J03886; AAA41625.1; ALT_SEQ; mRNA.
DR   IPI; IPI00231488; -.
DR   PIR; A28798; A28798.
DR   RefSeq; NP_476557.1; NM_057209.1.
DR   UniGene; Rn.81191; -.
DR   ProteinModelPortal; P20689; -.
DR   MINT; MINT-1346460; -.
DR   STRING; P20689; -.
DR   PhosphoSite; P20689; -.
DR   PRIDE; P20689; -.
DR   GeneID; 117558; -.
DR   KEGG; rno:117558; -.
DR   UCSC; NM_057209; rat.
DR   CTD; 85366; -.
DR   RGD; 620934; Mylk2.
DR   eggNOG; roNOG15964; -.
DR   GeneTree; ENSGT00600000084057; -.
DR   InParanoid; P20689; -.
DR   OrthoDB; EOG4868C5; -.
DR   PhylomeDB; P20689; -.
DR   BRENDA; 2.7.11.18; 5301.
DR   NextBio; 620419; -.
DR   Genevestigator; P20689; -.
DR   GermOnline; ENSRNOG00000008235; Rattus norvegicus.
DR   GO; GO:0043197; C:dendritic spine; IDA:RGD.
DR   GO; GO:0043025; C:neuronal cell body; IDA:RGD.
DR   GO; GO:0014069; C:postsynaptic density; IDA:RGD.
DR   GO; GO:0008021; C:synaptic vesicle; IDA:RGD.
DR   GO; GO:0043195; C:terminal button; IDA:RGD.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR   GO; GO:0032027; F:myosin light chain binding; IMP:RGD.
DR   GO; GO:0004687; F:myosin light chain kinase activity; IDA:RGD.
DR   GO; GO:0018105; P:peptidyl-serine phosphorylation; TAS:RGD.
DR   GO; GO:0051272; P:positive regulation of cellular component movement; IMP:RGD.
DR   GO; GO:0031448; P:positive regulation of fast-twitch skeletal muscle fiber contraction; IMP:RGD.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:RGD.
DR   GO; GO:0043408; P:regulation of MAPKKK cascade; IMP:RGD.
DR   GO; GO:0048168; P:regulation of neuronal synaptic plasticity; IMP:RGD.
DR   GO; GO:0048489; P:synaptic vesicle transport; IMP:RGD.
DR   GO; GO:0006833; P:water transport; IMP:RGD.
DR   InterPro; IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR015730; Myosin_light_ch_kinase.
DR   InterPro; IPR000719; Prot_kinase_cat_dom.
DR   InterPro; IPR017441; Protein_kinase_ATP_BS.
DR   InterPro; IPR017442; Se/Thr_kinase-like_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   InterPro; IPR002290; Ser/Thr_kinase_dom.
DR   PANTHER; PTHR24347; PTHR24347; 1.
DR   PANTHER; PTHR24347:SF19; PTHR24347:SF19; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF56112; Kinase_like; 1.
DR   PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR   HOGENOMDNA; RAT3.PE2171; -.
KW   ENSRNOG00000008235820036002503210000011;
KW   MYLK2_RAT; J03886;
KW   Acetylation; ATP-binding; Calmodulin-binding; Complete proteome;
KW   Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
SQ   SEQUENCE   610 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MATENGAVEL GTQSLSTEQT PKDAAGDGSP ASEKEPSLPD TEKDLGPTNT KKDPGAPDPK
     KNPDPPSLKK TPEAPGPEKK GDSAPASASN QGPSGEGDGG GGPAEGGTGP PAVLPQPTAT
     ADASIQKLDA TQAPSGNQES GEAKAGKKAA ECREAGRRGS PAFLHSPSCP AIISCSEKTL
     AMKPLSETTE LIFAGVSETP DPQDPGPAKA EGGTNTLAER KEEAEAGQAE QAKVQGDTSQ
     RIGFQAVPSE RAEVGQALCL TAKEEDCFQI LDDCPPPPAP FPHRIVELRT GNVNSEFSMN
     SKEALGGGKF GAVCTCTERS TGLKLAAKVI KKQTPKDKEM VLLEIEVMNQ LNHRNLIQLY
     SAIETSHEII LFMEYIEGGE LFERIVDEDY QLTEVDTMVF VRQICDGILF MHKMRVLHLD
     LKPENILCVN TTGHLVKIID FGLARRYNPN EKLKVNFGTP EFLSPEVVNY DQISDKTDMW
     SLGVITYMLL SGLSPFLGDD DTETLNNVLS ANWYFDEETF EAVSDEAKDF VSNLITKDQS
     ARMSAEQCLA HPWLNNLAEK AKRCNRRLKS QILLKKYLMK RRWKKNFIAV SAANRFKKIS
     SSGALMALGV
//

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