(data stored in ACNUC3759 zone)

HOGENOM: RAT4_PE1055

ID   RAT4_PE1055                          STANDARD;      PRT;   376 AA.
AC   RAT4_PE1055; P22355;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Pulmonary surfactant-associated protein B;
DE   Short=SP-B;AltName: Full=Pulmonary surfactant-associated proteolipid
DE   SPL(Phe);Flags: Precursor; (RAT4.PE1055).
GN   Name=Sftpb; Synonyms=Sftp3;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT4.PE1055.
CC       Rattus norvegicus chromosome 4 RGSC3.4  sequence 1..187126005
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:PSPB_RAT
CC   -!- FUNCTION: Pulmonary surfactant-associated proteins promote
CC       alveolar stability by lowering the surface tension at the air-
CC       liquid interface in the peripheral air spaces. SP-B increases the
CC       collapse pressure of palmitic acid to nearly 70 millinewtons per
CC       meter.
CC   -!- SUBUNIT: Homodimer; disulfide-linked.
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, surface film.
CC   -!- MISCELLANEOUS: Pulmonary surfactant consists of 90% lipid and 10%
CC       protein. There are 4 surfactant-associated proteins: 2
CC       collagenous, carbohydrate-binding glycoproteins (SP-A and SP-D)
CC       and 2 small hydrophobic proteins (SP-B and SP-C).
CC   -!- SIMILARITY: Contains 1 saposin A-type domain.
CC   -!- SIMILARITY: Contains 3 saposin B-type domains.
CC   -!- GENE_FAMILY: HOG000115745 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000010761;ENSRNOT00000014505;ENSRNOP00000014505.
DR   EMBL; BC072466; - ;
DR   EMBL; CH473957; - ;
DR   EMBL; X14778; - ;
DR   UniProtKB/Swiss-Prot; P22355; -.
DR   EMBL; X14778; CAA32885.1; -; mRNA.
DR   IPI; IPI00206151; -.
DR   PIR; S02766; S02766.
DR   RefSeq; NP_620197.1; NM_138842.1.
DR   UniGene; Rn.1952; -.
DR   ProteinModelPortal; P22355; -.
DR   STRING; P22355; -.
DR   GeneID; 192155; -.
DR   KEGG; rno:192155; -.
DR   UCSC; NM_138842; rat.
DR   CTD; 6439; -.
DR   RGD; 621700; Sftpb.
DR   eggNOG; roNOG17970; -.
DR   InParanoid; P22355; -.
DR   OrthoDB; EOG434W6C; -.
DR   NextBio; 622719; -.
DR   ArrayExpress; P22355; -.
DR   Genevestigator; P22355; -.
DR   GermOnline; ENSRNOG00000010761; Rattus norvegicus.
DR   GO; GO:0005615; C:extracellular space; IDA:RGD.
DR   GO; GO:0042599; C:lamellar body; IDA:RGD.
DR   GO; GO:0005764; C:lysosome; IEA:InterPro.
DR   GO; GO:0005771; C:multivesicular body; IDA:RGD.
DR   GO; GO:0071260; P:cellular response to mechanical stimulus; IEP:RGD.
DR   GO; GO:0071732; P:cellular response to nitric oxide; IEP:RGD.
DR   GO; GO:0007623; P:circadian rhythm; IEP:RGD.
DR   GO; GO:0050828; P:regulation of liquid surface tension; TAS:RGD.
DR   GO; GO:0007585; P:respiratory gaseous exchange; IEA:UniProtKB-KW.
DR   GO; GO:0070849; P:response to epidermal growth factor stimulus; IEP:RGD.
DR   GO; GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
DR   GO; GO:0009749; P:response to glucose stimulus; IEP:RGD.
DR   GO; GO:0055093; P:response to hyperoxia; IEP:RGD.
DR   GO; GO:0001666; P:response to hypoxia; IEP:RGD.
DR   GO; GO:0070741; P:response to interleukin-6; IEP:RGD.
DR   GO; GO:0032496; P:response to lipopolysaccharide; IEP:RGD.
DR   GO; GO:0033189; P:response to vitamin A; IEP:RGD.
DR   GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR   InterPro; IPR003119; SapA.
DR   InterPro; IPR007856; SapB_1.
DR   InterPro; IPR008138; SapB_2.
DR   InterPro; IPR008373; Saposin.
DR   InterPro; IPR011001; Saposin-like.
DR   InterPro; IPR008139; SaposinB.
DR   Gene3D; G3DSA:1.10.225.10; Saposin_like; 3.
DR   Pfam; PF02199; SapA; 1.
DR   Pfam; PF05184; SapB_1; 1.
DR   Pfam; PF03489; SapB_2; 3.
DR   PRINTS; PR01797; SAPOSIN.
DR   SMART; SM00162; SAPA; 1.
DR   SMART; SM00741; SapB; 3.
DR   SUPFAM; SSF47862; Saposin_like; 3.
DR   PROSITE; PS51110; SAP_A; 1.
DR   PROSITE; PS50015; SAP_B; 3.
DR   HOGENOMDNA; RAT4.PE1055; -.
KW   ENSRNOG00000010761820036002503210000011;
KW   Sftpb; PSPB_RAT; Q6IN44_RAT; BC072466; CH473957; X14778;
KW   Complete proteome; Disulfide bond; Gaseous exchange; Glycoprotein;
KW   Reference proteome; Repeat; Secreted; Signal; Surface film.
SQ   SEQUENCE   376 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAKLHLQWLL LLPTLCSLGA ATESASSPDC AQGPKFWCQS LEQAIQCRAL GHCLQEVWGH
     AGANDLCQEC EDIVHLLTKM TKEDAFQDTI RKFLEQECDI LPLKLLVPRC RQVLDVYLPL
     VIDYFQGQIK PKAICSHVGL CPLGQTKPEQ KPEMLDAIPN PLLNKLVLPA LPGAFLARPG
     PHTQDLSEQQ LPIPLPFCWL CRTLIKRVQA VIPKGVLAVA VSQVCHVVPL VVGGICQCLA
     ERYTVLLLDA LLGRVVPQLV CGLVLRCSTA DAIGPALPAL EPLIEKWPLQ DTECHFCKSV
     INQAWNTSEQ AMPQAMHQAC LRFWLDRQKC EQFVERHMPQ LLALVPRSQD AHTSCQALGV
     CEAPASPLQC FQTPHL
//

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