(data stored in ACNUC3759 zone)

HOGENOM: RAT4_PE1064

ID   RAT4_PE1064                          STANDARD;      PRT;   758 AA.
AC   RAT4_PE1064; O88496;
DT   00-JAN-0000 (Rel. 1, Created)
DT   00-JAN-0000 (Rel. 2, Last sequence update)
DT   00-JAN-0000 (Rel. 3, Last annotation update)
DE   RecName: Full=Vitamin K-dependent gamma-carboxylase; EC=4.1.1 90;AltName:
DE   Full=Gamma-glutamyl carboxylase;AltName: Full=Peptidyl-glutamate
DE   4-carboxylase;AltName: Full=Vitamin K gamma glutamyl carboxylase;
DE   (RAT4.PE1064).
GN   Name=Ggcx;
OS   RATTUS NORVEGICUS.
OC   Eukaryota; Metazoa; Eumetazoa; Bilateria; Coelomata; Deuterostomia;
OC   Chordata; Craniata; Vertebrata; Gnathostomata; Teleostomi; Euteleostomi;
OC   Sarcopterygii; Tetrapoda; Amniota; Mammalia; Theria; Eutheria;
OC   Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [0]
RP   -.;
RG   -.;
RL   -.;
CC   -!- SEQ. DATA ORIGIN: Translated from the HOGENOM CDS RAT4.PE1064.
CC       Rattus norvegicus chromosome 4 RGSC3.4  sequence 1..187126005
CC       annotated by Ensembl
CC   -!- ANNOTATIONS ORIGIN:VKGC_RAT
CC   -!- FUNCTION: Mediates the vitamin K-dependent carboxylation of
CC       glutamate residues to calcium-binding gamma-carboxyglutamate (Gla)
CC       residues with the concomitant conversion of the reduced
CC       hydroquinone form of vitamin K to vitamin K epoxide.
CC   -!- CATALYTIC ACTIVITY: [Peptidyl]-4-carboxyglutamate + 2,3-
CC       epoxyphylloquinone + H(2)O = [peptidyl]-glutamate + CO(2) + O(2) +
CC       phylloquinone.
CC   -!- SUBUNIT: Monomer (By similarity). Interacts with CALU.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass
CC       membrane protein (By similarity).
CC   -!- MISCELLANEOUS: The vitamin K-dependent protein substrates of
CC       carboxylase have usually a propeptide that binds to a high-
CC       affinity site on the carboxylase. CO(2), O(2) and reduced vitamin
CC       K are cosubstrates.
CC   -!- SIMILARITY: Belongs to the vitamin K-dependent gamma-carboxylase
CC       family.
CC   -!- GENE_FAMILY: HOG000007593 [ FAMILY / ALN / TREE ]
DR   HOGENOM:Rattus_norvegicus;ENSRNOG00000012975;ENSRNOT00000017927;ENSRNOP00000017928.
DR   EMBL; AF065387; - ;
DR   EMBL; BC168647; - ;
DR   EMBL; CH473957; - ;
DR   UniProtKB/Swiss-Prot; O88496; -.
DR   EMBL; AF065387; AAC82374.1; -; mRNA.
DR   IPI; IPI00209795; -.
DR   RefSeq; NP_113944.1; NM_031756.1.
DR   UniGene; Rn.22410; -.
DR   STRING; O88496; -.
DR   PRIDE; O88496; -.
DR   GeneID; 81716; -.
DR   KEGG; rno:81716; -.
DR   UCSC; NM_031756; rat.
DR   CTD; 2677; -.
DR   RGD; 68383; Ggcx.
DR   eggNOG; roNOG05130; -.
DR   GeneTree; ENSGT00390000014909; -.
DR   InParanoid; O88496; -.
DR   OrthoDB; EOG4KH2TJ; -.
DR   NextBio; 615355; -.
DR   ArrayExpress; O88496; -.
DR   Genevestigator; O88496; -.
DR   GermOnline; ENSRNOG00000012975; Rattus norvegicus.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008488; F:gamma-glutamyl carboxylase activity; IEA:InterPro.
DR   GO; GO:0009790; P:embryo development; IEP:RGD.
DR   GO; GO:0017187; P:peptidyl-glutamic acid carboxylation; IDA:RGD.
DR   GO; GO:0032571; P:response to vitamin K; IEP:RGD.
DR   InterPro; IPR011051; Cupin_RmlC_type.
DR   InterPro; IPR011020; HTTM.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR007782; VKG_COase.
DR   Gene3D; G3DSA:2.60.120.10; RmlC-like_jellyroll; 1.
DR   PANTHER; PTHR12639; VKG_carbox; 1.
DR   Pfam; PF05090; VKG_Carbox; 1.
DR   SMART; SM00752; HTTM; 1.
DR   SUPFAM; SSF51182; RmlC_like_cupin; 1.
DR   HOGENOMDNA; RAT4.PE1064; -.
KW   ENSRNOG00000012975820036002503210000011;
KW   Ggcx; VKGC_RAT; B5DEF3_RAT; AF065387; BC168647; CH473957;
KW   Acetylation; Complete proteome; Disulfide bond; Endoplasmic reticulum;
KW   Lyase; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
SQ   SEQUENCE   758 AA;  UNKNOWN MW;  UNKNOWN CRC64;
     MAVHRGSARA APASDKVQKN KPAQTSGLKQ GSRMAKIFGF EWADLSSWQS VVTLLNRPTD
     PANLAVFRFL FAFLMLLDIP QERGLSSLDR KYLDGLDVCR FPLLDALRPL PLDWMYLVYT
     IMFLGALGMM LGLWYRLSCV LFLLPYWYVF LLDKTSWNNH SYLYGLLAFQ LTFMDANHYW
     SVDGLLSAQK KNAHVPLWNY TVLRGQIFIV YFIAGVKKLD ADWVEGYSME HLSRHWLFSP
     FKLVLSEELT SLLVVHWCGL LLDLSAGFLL FFDASRPIGL VFVSYFHCMN SQLFSIGMFP
     YVMLASSPLF CSAEWPRKLV ARCPKRLQEL LPAKAAPRPS ASCVYKRARA KAGQKPGLRH
     HLGAVFTLLY LLEQLFLPYS HFLTQGYNNW TNGLYGYSWD MMVHSRSHQH VKITYRDGLT
     GELGYLNPGV FTQSRRWKDH ADMLKQYATC LSLLLPKYNV TEPQIYFDIW VSINDRFQQR
     LFDPRVDIVQ AVWSPFRRTP WVQPLLMDLS PWRTKLQDIK SSLDNHTEVV FIADFPGLHL
     ENFVSEDLGN TSIQLLQGEV TVELVAEQKN QTLREGEKMQ LPAGEYHKVY TVSSSPSCYM
     YVYVNTTEVA LEQDLAYLQE LKEKVENGSE TGPLPPELQP LLEGEVKGGP EPTPLVQTFL
     RRQRKLQEIE RRRNSPLHER FLRFVLRKLY VFRRSFLMTR ISLRNLLFGR PSLEQLAQEV
     TYANLRPFEP VDESSASNTD SSDPHPSEPD SEHVHSEL
//

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